Dig Dis & Sci: 肥胖可能会导致溃疡性结肠炎患者艰难梭菌的感染几率增加

2018-06-24 MedSci MedSci原创

与普通人群相比,溃疡性结肠炎(UC)患者的艰难梭菌感染(CDI)的风险是增加。最近的数据表明,肥胖也增加了CDI感染的风险。本项研究旨在研究肥胖是否影响UC患者的CDI风险。

背景
与普通人群相比,溃疡性结肠炎(UC)患者的艰难梭菌感染(CDI)的风险是增加。最近的数据表明,肥胖也增加了CDI感染的风险。本项研究旨在研究肥胖是否影响UC患者的CDI风险。

方法
研究人员对2014年1月1日至2015年12月31日就诊的UC患者进行了回顾性横断面研究。使用体重指数(BMI)将患者分为体重不足(BMI <18.5),体重正常(18.5≤BMI <25),超重(25≤BMI <30)和肥胖BMI≥30)四组。采用年龄校正和多变量logistic回归分析,分析项目包括性别,吸烟,UC病程和维生素D缺乏。

结果
在636例UC患者中,114例(18%)肥胖,232例(36%)超重,274例(43%)正常体重和16例(2.5%)体重不足。在研究期间,有19名患者(3.0%)患有CDI。CDI风险与BMI无关(OR 0.90,95%CI 0.79-1.02)。与正常体重患者相比,CDI的风险不受肥胖影响(OR 0.63,95%CI 0.15-2.58),超重(OR 0.33,95%CI 0.08-1.30)或体重不足(OR 2.98,95 %CI 0.45-19.83)。CDI与以往使用TNF治疗有关(OR 6.09,95%CI 2.07-17.93)。

结论
UC患者中肥胖症似乎与艰难梭菌感染的风险相关。

原始出处:

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  2. [GetPortalCommentsPageByObjectIdResponse(id=2012721, encodeId=a6962012e215f, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sun Mar 03 18:00:00 CST 2019, time=2019-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1695029, encodeId=8f851695029b0, content=<a href='/topic/show?id=c76e6645438' target=_blank style='color:#2F92EE;'>#溃疡性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66454, encryptionId=c76e6645438, topicName=溃疡性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=787129789891, createdName=nymo, createdTime=Mon Sep 17 07:00:00 CST 2018, time=2018-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327646, encodeId=5bb432e64645, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Thu Jun 28 10:07:41 CST 2018, time=2018-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326977, encodeId=cf8b3269e740, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Mon Jun 25 22:05:10 CST 2018, time=2018-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326975, encodeId=005e3269e521, content=肥胖还是万病之源, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/06/03/9492162094174b7d9f8b15908e88fb47.jpg, createdBy=e6ff2327664, createdName=12262e46m80暂无昵称, createdTime=Mon Jun 25 20:58:32 CST 2018, time=2018-06-25, status=1, ipAttribution=)]
    2018-09-17 nymo
  3. [GetPortalCommentsPageByObjectIdResponse(id=2012721, encodeId=a6962012e215f, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sun Mar 03 18:00:00 CST 2019, time=2019-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1695029, encodeId=8f851695029b0, content=<a href='/topic/show?id=c76e6645438' target=_blank style='color:#2F92EE;'>#溃疡性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66454, encryptionId=c76e6645438, topicName=溃疡性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=787129789891, createdName=nymo, createdTime=Mon Sep 17 07:00:00 CST 2018, time=2018-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327646, encodeId=5bb432e64645, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Thu Jun 28 10:07:41 CST 2018, time=2018-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326977, encodeId=cf8b3269e740, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Mon Jun 25 22:05:10 CST 2018, time=2018-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326975, encodeId=005e3269e521, content=肥胖还是万病之源, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/06/03/9492162094174b7d9f8b15908e88fb47.jpg, createdBy=e6ff2327664, createdName=12262e46m80暂无昵称, createdTime=Mon Jun 25 20:58:32 CST 2018, time=2018-06-25, status=1, ipAttribution=)]
    2018-06-28 一天没事干

    很好的学习机会

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2012721, encodeId=a6962012e215f, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sun Mar 03 18:00:00 CST 2019, time=2019-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1695029, encodeId=8f851695029b0, content=<a href='/topic/show?id=c76e6645438' target=_blank style='color:#2F92EE;'>#溃疡性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66454, encryptionId=c76e6645438, topicName=溃疡性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=787129789891, createdName=nymo, createdTime=Mon Sep 17 07:00:00 CST 2018, time=2018-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327646, encodeId=5bb432e64645, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Thu Jun 28 10:07:41 CST 2018, time=2018-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326977, encodeId=cf8b3269e740, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Mon Jun 25 22:05:10 CST 2018, time=2018-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326975, encodeId=005e3269e521, content=肥胖还是万病之源, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/06/03/9492162094174b7d9f8b15908e88fb47.jpg, createdBy=e6ff2327664, createdName=12262e46m80暂无昵称, createdTime=Mon Jun 25 20:58:32 CST 2018, time=2018-06-25, status=1, ipAttribution=)]
    2018-06-25 大爰

    学习并分享!!

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2012721, encodeId=a6962012e215f, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sun Mar 03 18:00:00 CST 2019, time=2019-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1695029, encodeId=8f851695029b0, content=<a href='/topic/show?id=c76e6645438' target=_blank style='color:#2F92EE;'>#溃疡性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66454, encryptionId=c76e6645438, topicName=溃疡性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=787129789891, createdName=nymo, createdTime=Mon Sep 17 07:00:00 CST 2018, time=2018-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327646, encodeId=5bb432e64645, content=很好的学习机会, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/12/cd30eefc465f70dc4dad89bd57479781.jpg, createdBy=02be2318568, createdName=一天没事干, createdTime=Thu Jun 28 10:07:41 CST 2018, time=2018-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326977, encodeId=cf8b3269e740, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Mon Jun 25 22:05:10 CST 2018, time=2018-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326975, encodeId=005e3269e521, content=肥胖还是万病之源, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/06/03/9492162094174b7d9f8b15908e88fb47.jpg, createdBy=e6ff2327664, createdName=12262e46m80暂无昵称, createdTime=Mon Jun 25 20:58:32 CST 2018, time=2018-06-25, status=1, ipAttribution=)]
    2018-06-25 12262e46m80暂无昵称

    肥胖还是万病之源

    0

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