J Rheumatol:睡眠质量与广泛性疼痛患者的膝关节疼痛加重有关

2019-11-21 xiangting MedSci原创

在广泛性疼痛中,睡眠质量高与膝关节疼痛加重较少见有关。

这里研究了睡眠与膝关节疼痛发生率之间的关联,以及这种关系是否因广泛性疼痛(WSP)的状态而异。

在多中心骨关节炎研究的60个月访问中,通过使用来自两个经验证问卷中的一项来评估睡眠质量和不安定睡眠。每个睡眠指标均分为三个等级,以睡眠差/最不安宁的睡眠作为对照。根据美国风湿病学会的标准,WSP被定义为使用标准人体模型身体两侧轴向腰部上方和下方的疼痛。60-84个月的结局包括:1)膝关节疼痛加重(KPW,定义为WOMAC疼痛临床上的最小差异),2)好发性 和3)持续偶发膝关节疼痛。在多因素logistic回归模型中应用广义估计方程。

共研究了2329名参与者(4658个膝关节)[67.9岁,BMI30.9]。研究发现WSP改变了睡眠质量与KPW之间的关系(交互作用p<0.01)。在WSP患者中,睡眠质量非常好的人KPW的比值比(95%置信区间)为0.540.350.78)(p趋势<0.001);此外,研究发现在疼痛关节>8个的患者中,睡眠质量的关联性最强(p趋势<0.01),而在疼痛关节部位≤2个的患者中则没有关联。在存在WSP时,使用不安定睡眠也观察到相似结果。睡眠与持续性膝关节疼痛的患病率之间存在明显的断面关系。

在广泛性疼痛中,睡眠质量高与膝关节疼痛加重较少见有关。

原始出处:

Zhaoli Dai. Sleep quality is related to worsening knee pain in those with widespread pain: The Multicenter Osteoarthritis Study. J Rheumatol. 15 November 2019.

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