CDSR：己酮可可碱在预防早产儿支气管肺发育不良的作用

2021-09-10 从医路漫漫 MedSci原创

背景：支气管肺发育不良(BPD)是早产儿常见的并发症。BPD与长期不良的呼吸和神经发育结局以及死亡率增加有关。预防性使用调节炎症的药物，如己酮可可碱，一种合成的甲基黄嘌呤和磷酸二酯酶抑制剂，可能会降低

背景：支气管肺发育不良(BPD)是早产儿常见的并发症。BPD与长期不良的呼吸和神经发育结局以及死亡率增加有关。预防性使用调节炎症的药物，如己酮可可碱，一种合成的甲基黄嘌呤和磷酸二酯酶抑制剂，可能会降低BPD的发生率。

目的：探讨己酮可可碱对BPD发生率、校正胎龄(PMA)后36周前死亡和早产儿BPD或36周前PMA前死亡。

结果：雾化吸入己酮可可碱与安慰剂相比，对36周PMA时BPD的个体结局或36周前PMA死亡的个体结局没有统计学差异。雾化吸入己酮可可碱对脑室出血、脑室周围白质软化、脓毒症或需要治疗的动脉导管未闭(PDA)没有显著影响。不良事件的报告非常有限，无法对此类事件的发生率作出可靠的判断。没有长期结果的报道。

表雾化吸入己酮可可碱与安慰剂对照

结论：没有足够的证据来确定己酮可可碱预防早产儿BPD的安全性和有效性。

原文出处

Schulzke SM, Kaempfen S, Patole SK,Pentoxifylline for the prevention of bronchopulmonary dysplasia in preterm infants.Cochrane Database Syst Rev 2014 Nov 24;(11)

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2022-08-21 flyingeagle77

#肺发育不良#

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2022-01-02 zjubiostat

#支气管#

42 0
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2021-10-27 zjubiostat

#己酮可可碱#

46 0
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2021-09-12 neurowu

#发育#

36 0
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2021-09-12 photoman

#支气管肺发育不良#

36 0
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2021-09-12 yangpeizhi

#CDS#

37 0
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2021-09-12 villahu

#发育不良#

38 0
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2021-09-10 临床小白

已学习

53 0

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