CORR:创伤性肘关节不稳影像学诊断的可信度良好

2013-05-29 CORR dxy

肘关节部位骨折合并关节脱位发生率较低,因而创伤外科医生对该疾病诊断可能并没有像其他部位骨折一样来的准确。对肘关节骨折类型的判断可以较为精确地评估患者软组织损伤程度和骨折的发生机制,为后续治疗提供参考。目前尚无创伤骨科医生评估肘关节骨折分型精确性和一致性的研究报道,近日来自美国的学者就此进行了相关研究,并阐述了下列问题:1.骨科医生对创伤性肘关节不稳定骨折分型的组间一致性;2.影像学诊断肘关节骨折类

肘关节部位骨折合并关节脱位发生率较低,因而创伤外科医生对该疾病诊断可能并没有像其他部位骨折一样来的准确。对肘关节骨折类型的判断可以较为精确地评估患者软组织损伤程度和骨折的发生机制,为后续治疗提供参考。目前尚无创伤骨科医生评估肘关节骨折分型精确性和一致性的研究报道,近日来自美国的学者就此进行了相关研究,并阐述了下列问题:1.骨科医生对创伤性肘关节不稳定骨折分型的组间一致性;2.影像学诊断肘关节骨折类型的准确性。

研究者在网络上发出调查邀请,共76位骨科医生接受邀请,73位(96%)医生完成调查。调查问卷的组成为53例肘关节骨折患者的影像学X片,入选X片符合以下标准:创伤性肘关节不稳定;X片图片清晰;年龄大于18岁。53例肘关节骨折片共有:桡骨头骨折伴后脱位(7例);恐怖三联征(19例);内翻后内侧旋转损伤(4例);尺骨鹰嘴骨折伴肘关节前脱位(5例);尺骨鹰嘴骨折伴肘关节后脱位(18例),如图1所示。所有诊断均经过开放手术确认。

 
图1:五种不同类型的创伤性肘关节不稳定。

研究结果提示:

不同骨科医生间的总体组间一致性K=0.41,当对观察者按不同标准进行分组比较后发现,其组间一致性相当,组间一致性和每年治疗的病例数有关,而和手术医生的工作年限无关,即每年治疗肘关节骨折病例数大于5例的医生具有较高的组间一致性,(如表1所示)。

表1:观察者的Kappa值
 

观察者的总体诊断诊断准确率在80%,范围在76%-93%之间浮动,其中诊断尺骨鹰嘴骨折的准确率最好,诊断肘关节恐怖三联征准确率最低(如表2,3,附录1,2所示)。

表2:损伤类型的一致性百分比

表3:影像学诊断准确性的分布

附录1:每一例患者一致性分布
 

附录2:肘关节骨折诊断准确性的分布

研究者认为:创伤性肘关节不稳定诊断在不同骨科医生间中等程度的一致性,并且其精确性尚可接受。

Diagnosis of elbow fracture patterns on radiographs: interobserver reliability and diagnostic accuracy.
BACKGROUND
Studies of traumatic elbow instability suggest that recognition of a pattern in the combination and character of the fractures and joint displacements helps predict soft tissue injury and guide the treatment of traumatic elbow instability, but there is no evidence that patterns can be identified reliably.
QUESTIONS/PURPOSES
We therefore determined (1) the interobserver reliability of identifying specific patterns of traumatic elbow instability on radiographs for subgroups of orthopaedic surgeons; and (2) the diagnostic accuracy of radiographic diagnosis.
METHODS
Seventy-three orthopaedic surgeons evaluated 53 sets of radiographs and diagnosed one of five common patterns of traumatic elbow instability by using a web-based survey. The interobserver reliability was analyzed using Cohen's multirater kappa. Intraoperative diagnosis was the reference for fracture pattern in calculations of the sensitivity, specificity, accuracy, and positive predictive and negative predictive values of radiographic diagnosis.
RESULTS
The overall interobserver reliability for patterns of traumatic elbow instability on radiographs was κ=0.41. Treatment of greater than five such injuries a year was associated with greater interobserver agreement, but years in practice were not. Diagnostic accuracy ranged from 76% to 93% and was lowest for the terrible triad pattern of injury.
CONCLUSIONS
Specific patterns of traumatic elbow instability can be diagnosed with moderate interobserver reliability and reasonable accuracy on radiographs.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2060634, encodeId=cdb9206063414, content=<a href='/topic/show?id=0d1f50290a8' target=_blank style='color:#2F92EE;'>#影像学诊断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50290, encryptionId=0d1f50290a8, topicName=影像学诊断)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fa4f352, createdName=chenlianhui, createdTime=Wed Jan 15 15:19:00 CST 2014, time=2014-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2025414, encodeId=d929202541498, content=<a href='/topic/show?id=66f93204223' target=_blank style='color:#2F92EE;'>#创伤性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32042, encryptionId=66f93204223, topicName=创伤性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Thu Aug 01 21:19:00 CST 2013, time=2013-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634374, encodeId=a12316343e458, content=<a href='/topic/show?id=57ce8110820' target=_blank style='color:#2F92EE;'>#肘关节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81108, encryptionId=57ce8110820, topicName=肘关节)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fd5022160969, createdName=xugc, createdTime=Wed Jul 24 20:19:00 CST 2013, time=2013-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1335042, encodeId=e239133504207, content=<a href='/topic/show?id=e7cc32022c7' target=_blank style='color:#2F92EE;'>#创伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32022, encryptionId=e7cc32022c7, topicName=创伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Fri May 31 01:19:00 CST 2013, time=2013-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1590662, encodeId=97311590662ad, content=<a href='/topic/show?id=e31d134e83e' target=_blank style='color:#2F92EE;'>#ORR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13478, encryptionId=e31d134e83e, topicName=ORR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8a7b17846501, createdName=psybestwish, createdTime=Fri May 31 01:19:00 CST 2013, time=2013-05-31, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=2060634, encodeId=cdb9206063414, content=<a href='/topic/show?id=0d1f50290a8' target=_blank style='color:#2F92EE;'>#影像学诊断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50290, encryptionId=0d1f50290a8, topicName=影像学诊断)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fa4f352, createdName=chenlianhui, createdTime=Wed Jan 15 15:19:00 CST 2014, time=2014-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2025414, encodeId=d929202541498, content=<a href='/topic/show?id=66f93204223' target=_blank style='color:#2F92EE;'>#创伤性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32042, encryptionId=66f93204223, topicName=创伤性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Thu Aug 01 21:19:00 CST 2013, time=2013-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634374, encodeId=a12316343e458, content=<a href='/topic/show?id=57ce8110820' target=_blank style='color:#2F92EE;'>#肘关节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81108, encryptionId=57ce8110820, topicName=肘关节)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fd5022160969, createdName=xugc, createdTime=Wed Jul 24 20:19:00 CST 2013, time=2013-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1335042, encodeId=e239133504207, content=<a href='/topic/show?id=e7cc32022c7' target=_blank style='color:#2F92EE;'>#创伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32022, encryptionId=e7cc32022c7, topicName=创伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Fri May 31 01:19:00 CST 2013, time=2013-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1590662, encodeId=97311590662ad, content=<a href='/topic/show?id=e31d134e83e' target=_blank style='color:#2F92EE;'>#ORR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13478, encryptionId=e31d134e83e, topicName=ORR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8a7b17846501, createdName=psybestwish, createdTime=Fri May 31 01:19:00 CST 2013, time=2013-05-31, status=1, ipAttribution=)]
    2013-08-01 amyloid
  3. [GetPortalCommentsPageByObjectIdResponse(id=2060634, encodeId=cdb9206063414, content=<a href='/topic/show?id=0d1f50290a8' target=_blank style='color:#2F92EE;'>#影像学诊断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50290, encryptionId=0d1f50290a8, topicName=影像学诊断)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fa4f352, createdName=chenlianhui, createdTime=Wed Jan 15 15:19:00 CST 2014, time=2014-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2025414, encodeId=d929202541498, content=<a href='/topic/show?id=66f93204223' target=_blank style='color:#2F92EE;'>#创伤性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32042, encryptionId=66f93204223, topicName=创伤性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Thu Aug 01 21:19:00 CST 2013, time=2013-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634374, encodeId=a12316343e458, content=<a href='/topic/show?id=57ce8110820' target=_blank style='color:#2F92EE;'>#肘关节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81108, encryptionId=57ce8110820, topicName=肘关节)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fd5022160969, createdName=xugc, createdTime=Wed Jul 24 20:19:00 CST 2013, time=2013-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1335042, encodeId=e239133504207, content=<a href='/topic/show?id=e7cc32022c7' target=_blank style='color:#2F92EE;'>#创伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32022, encryptionId=e7cc32022c7, topicName=创伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Fri May 31 01:19:00 CST 2013, time=2013-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1590662, encodeId=97311590662ad, content=<a href='/topic/show?id=e31d134e83e' target=_blank style='color:#2F92EE;'>#ORR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13478, encryptionId=e31d134e83e, topicName=ORR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8a7b17846501, createdName=psybestwish, createdTime=Fri May 31 01:19:00 CST 2013, time=2013-05-31, status=1, ipAttribution=)]
    2013-07-24 xugc
  4. [GetPortalCommentsPageByObjectIdResponse(id=2060634, encodeId=cdb9206063414, content=<a href='/topic/show?id=0d1f50290a8' target=_blank style='color:#2F92EE;'>#影像学诊断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50290, encryptionId=0d1f50290a8, topicName=影像学诊断)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fa4f352, createdName=chenlianhui, createdTime=Wed Jan 15 15:19:00 CST 2014, time=2014-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2025414, encodeId=d929202541498, content=<a href='/topic/show?id=66f93204223' target=_blank style='color:#2F92EE;'>#创伤性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32042, encryptionId=66f93204223, topicName=创伤性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Thu Aug 01 21:19:00 CST 2013, time=2013-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634374, encodeId=a12316343e458, content=<a href='/topic/show?id=57ce8110820' target=_blank style='color:#2F92EE;'>#肘关节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81108, encryptionId=57ce8110820, topicName=肘关节)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fd5022160969, createdName=xugc, createdTime=Wed Jul 24 20:19:00 CST 2013, time=2013-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1335042, encodeId=e239133504207, content=<a href='/topic/show?id=e7cc32022c7' target=_blank style='color:#2F92EE;'>#创伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32022, encryptionId=e7cc32022c7, topicName=创伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Fri May 31 01:19:00 CST 2013, time=2013-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1590662, encodeId=97311590662ad, content=<a href='/topic/show?id=e31d134e83e' target=_blank style='color:#2F92EE;'>#ORR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13478, encryptionId=e31d134e83e, topicName=ORR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8a7b17846501, createdName=psybestwish, createdTime=Fri May 31 01:19:00 CST 2013, time=2013-05-31, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=2060634, encodeId=cdb9206063414, content=<a href='/topic/show?id=0d1f50290a8' target=_blank style='color:#2F92EE;'>#影像学诊断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50290, encryptionId=0d1f50290a8, topicName=影像学诊断)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fa4f352, createdName=chenlianhui, createdTime=Wed Jan 15 15:19:00 CST 2014, time=2014-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2025414, encodeId=d929202541498, content=<a href='/topic/show?id=66f93204223' target=_blank style='color:#2F92EE;'>#创伤性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32042, encryptionId=66f93204223, topicName=创伤性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=325a197, createdName=amyloid, createdTime=Thu Aug 01 21:19:00 CST 2013, time=2013-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634374, encodeId=a12316343e458, content=<a href='/topic/show?id=57ce8110820' target=_blank style='color:#2F92EE;'>#肘关节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81108, encryptionId=57ce8110820, topicName=肘关节)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fd5022160969, createdName=xugc, createdTime=Wed Jul 24 20:19:00 CST 2013, time=2013-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1335042, encodeId=e239133504207, content=<a href='/topic/show?id=e7cc32022c7' target=_blank style='color:#2F92EE;'>#创伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32022, encryptionId=e7cc32022c7, topicName=创伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Fri May 31 01:19:00 CST 2013, time=2013-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1590662, encodeId=97311590662ad, content=<a href='/topic/show?id=e31d134e83e' target=_blank style='color:#2F92EE;'>#ORR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13478, encryptionId=e31d134e83e, topicName=ORR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8a7b17846501, createdName=psybestwish, createdTime=Fri May 31 01:19:00 CST 2013, time=2013-05-31, status=1, ipAttribution=)]
    2013-05-31 psybestwish

相关资讯

Injury:桡骨远端骨折合并桡动脉损伤动脉修复效果良好

桡骨远端骨折合并桡动脉损伤在临床中较为少见,通常被认为是高能量损伤导致的一种少见的损伤,目前并没有单独报道两者合并损伤的文献资料,较难得出其具体发病率。因目前文献资料较少,很难对桡骨远段合并桡动脉损伤患者的临床特征和功能预后进行判断。近日来自美国Maryland大学医学院的学者进行了一项研究,针对其所在的一级创伤治疗中心数十例桡骨远端骨折合并桡动脉损伤的患者进行手术修复,对功能预后情况进行总结,相

CORR:肥胖并不会影响儿童骨折后恢复正常活动的时间

肥胖是大部分骨科疾病的危险因素,包括骨折。既往研究认为,肥胖患者往往存在内循环激素和细胞因子的代谢障碍,这些功能障碍最终通过影响骨组织的矿物化而增加骨折风险,影响骨折愈合过程。有学者认为,对肥胖患儿,身体重量的增加导致下肢负荷增加,而下肢骨骼质量相对应的增强,但上肢骨骼因不负重,其矿物化作用减弱,容易出现骨折。但事实上,肥胖对全身各个器官的功能影响存在多方面作用,目前肥胖对骨折,特别是儿童骨折的愈

JCEM:低维生素D状态是髋部骨折的危险因素

尽管循环25–羟维生素D与髋部骨折风险之间的关系相当重要,但到目前为止仍没有被充分确立。为了研究挪威,一个处在世界范围内最高髋部骨折发生率中的高纬度国家,血清25–羟维生素D浓度(s–25(OH)D)与髋部骨折风险之间的关系,来自挪威卑尔根大学的Kristin Holvik教授及其团队进行了一项研究,该研究发现血清25–羟维生素D的最低四分位数与最高四分位数相比,受试者的髋部骨折风险增加。与先前以

Spine:双Hangman骨折1例报道

创伤性脊柱前移是脊柱齿状突骨折后最容易出现的状况,通常发生在机动车祸患者中,这类患者通常特征是双侧椎弓根和椎体分离,伴或不伴有椎体的脱位,这类骨折在外文文献中被称为Hangman骨折,即上吊者骨折。本文报道1例罕见的C2,C3 双侧椎弓根断裂,伴C3椎体向前滑移而未出现脊髓神经压迫症状的病例。 病例报道: 35岁女性,因机动车祸时前额部撞击地面而出现颈部疼痛入院,参考颈椎损伤机制,该损伤类型为

JCEM:维生素D3和钙强化的乳制品能更好的预防骨吸收

对伴有维生素D缺乏、继发性甲状旁腺功能亢进、骨吸收增加和骨质疏松性骨折风险的缺乏自理能力的老年女性,使用强化食品对骨退化进行营养预防似乎是非常合适的。为了评估在老年女性,维生素D和钙的强化酸奶与相同热量和蛋白质的乳制品相比,是否能对血清甲状旁腺激素(PTH)和骨吸收标记物(BRM)发挥额外的降低效果,来自瑞士日内瓦大学医院的Jean Philippe Bonjour教授及其团队进行了一项研究,该研

骨质疏松治疗的新靶点

当前和未来的抗骨折治疗方法   对大型、全基因组关联研究的BMD荟萃分析揭示了BMD变异潜在的遗传结构和病理生理学机制  Semaphorin-3A是一个成骨细胞衍生的分泌性蛋白,通过减少成骨细胞分化和增加骨形成,具有增高骨量的作用  胃肠道微生物调节小鼠骨量,可能是治疗和预防骨质疏松的新靶点唑来膦酸治疗2年减少男性骨质疏松患者椎骨骨折风险   一直以来,研究人员都致力于开发更加安全、有效的抗