Congenit Heart Dis:法舒地尔可以改善CHD-PAH患者的血流动力学,特别是60-mg剂量

2020-04-12 MedSci原创 MedSci原创

在伴有严重肺动脉高压(CHD-PAH)的先天性心脏病患者中,法舒地尔的最佳剂量仍有争议。本研究旨在对比伴重症肺动脉高压的先天性心脏病成人患者中不同剂量的法舒地尔治疗后的急性血流动力学变化。

在伴有严重肺动脉高压(CHD-PAH)的先天性心脏病患者中,法舒地尔的最佳剂量仍有争议。本研究旨在对比伴重症肺动脉高压的先天性心脏病成人患者中不同剂量的法舒地尔治疗后的急性血流动力学变化。

 

纳入60例CHD-PAH的成人患者,将其随机分配到法舒地尔30或60毫克。通过右心导管检查,在基线和法舒地尔30分钟后测量血流动力学参数。从肺动脉、右心室、右心房、右心房、上腔静脉和下腔静脉、股动脉获得血气结果。计算了肺血管阻力(PVR)和全身动脉阻力(SVR)。

 

结果显示,The changes in systolic pulmonary artery pressure (sPAP)(-13.1% vs -9.3%,P < . 05)、平均PAP(mPAP)(-12.4% vs -8.5%,P < .05),以及PVR(-35.8% vs -22.2%,P < .05)在60-mg组中比30-mg组更明显。所有患者均无明显的与外周血压相关的不良反应。

 

总之,该研究结果表明,法舒地尔可以改善CHD-PAH患者的血流动力学,特别是60-mg剂量,可以改善患者的血流动力学,没有出现严重的不良反应。

 

原始出处:

 

Hongyun RuanYigang Zhang, et al., The Acute Effects of 30 Mg vs 60 Mg of Intravenous Fasudil on Patients With Congenital Heart Defects and Severe Pulmonary Arterial Hypertension. Congenit Heart Dis, 14 (4), 645-650

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    2020-04-14 zhaojie88
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    2020-04-14 hb2010ye
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    2020-04-14 slcumt

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