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Int J Cardiol：氟喹诺酮类药物与主动脉病变风险

2018-09-22 xing.T MedSci原创

氟喹诺酮类药物主动脉病变风险
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由此可见，该研究结果表明当前使用氟喹诺酮药物与主动脉瘤和夹层风险增加显著相关。卫生保健提供者需要了解这种严重的关联，并明智地使用氟喹诺酮类药物，以尽量减少主动脉病严重后遗症的风险。

近日，心血管领域权威杂志International Journal of Cardiology上发表了一篇研究文章，研究人员旨在调查氟喹诺酮类药物与主动脉病变发展之间的关系。

研究人员根据PRISMA和MOOSE指南进行了一项系统评价和荟萃分析。研究人员检索了多个数据库，两位作者独立筛选了符合条件的研究。纽卡斯尔渥太华量表用于评估纳入研究的质量。感兴趣的主要结局为与未使用氟喹诺酮类药物者相比，氟喹诺酮类药物使用者发生主动脉瘤或夹层。研究人员使用逆方差模型荟萃分析来汇总纳入研究中的比值比或风险比，以计算总体效应估计值。研究人员还进行了预先指定的亚组分析以探索异质性的来源。

共招募了941639名受试者的三项观察性研究符合纳入标准，并纳入最终分析。所有研究都具有良好的方法学质量。当前氟喹诺酮类药物使用被定义为在60天内发生主要结局，与对照组相比，使用氟喹诺酮类药物与发生主动脉瘤和/或夹层的风险显著升高有关（OR=2.04; 95％CI为1.67-2.48）。研究之间只有轻微程度的异质性，I2=33％。在所有亚组分析中，该关联仍然稳健。

由此可见，该研究结果表明当前使用氟喹诺酮药物与主动脉瘤和夹层风险增加显著相关。卫生保健提供者需要了解这种严重的关联，并明智地使用氟喹诺酮类药物，以尽量减少主动脉病严重后遗症的风险。

原始出处：

Anas T.Noman,et al. Fluoroquinolones and the risk of aortopathy: A systematic review and meta-analysis.International Journal of Cardiology.2018. https://doi.org/10.1016/j.ijcard.2018.09.067

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    2019-06-10 仁心济世

    #主动脉病#

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    2019-05-07 bettycmoon

    #氟喹诺酮类药物#

    0

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    2019-07-17 仁者大医

    #Cardiol#

    0

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    2018-12-04 sjzlzc007

    #喹诺酮#

    0

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    2018-12-14 siiner

    #主动脉病变#

    0

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    2018-09-24 circumcision

    #主动脉#

    0

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    2018-09-24 doctorzheng

    #氟喹诺酮#

    0

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