脂肪组织来源的干细胞提取、制备及储存质量管理专家共识

2018-10-01 中国医药生物技术协会 皮肤软组织修复与重建技术分会 解放军医学杂志.2018,43(10)811-815.

脂肪组织来源的干细胞(adipose tissue-derived stromal/stem cells,ASCs)是从脂肪组织中分离提取得到的,具有取材容易、对机体损伤小、体内储备量大、体外可大规模培养、多向分化潜能等优点。ASCs在人体修复重建、免疫调节及组织再生等方面的应用成为近年来干细胞储存的重要内容,也是组织工程及再生医学的研究热点。 大量研究表明,自体脂肪组织移植到软组织缺损部位后,其

中文标题:

脂肪组织来源的干细胞提取、制备及储存质量管理专家共识

发布日期:

2018-10-01

简要介绍:

脂肪组织来源的干细胞(adipose tissue-derived stromal/stem cells,ASCs)是从脂肪组织中分离提取得到的,具有取材容易、对机体损伤小、体内储备量大、体外可大规模培养、多向分化潜能等优点。ASCs在人体修复重建、免疫调节及组织再生等方面的应用成为近年来干细胞储存的重要内容,也是组织工程及再生医学的研究热点。 大量研究表明,自体脂肪组织移植到软组织缺损部位后,其中40%~60%会被吸收,自体脂肪组织结合ASCs移植,能明显减少自体脂肪组织移植的吸收、液化、坏死及纤维化等情况的发生,构建具有生物学结构和功能的脂肪组织,同时,利用提取脂肪组织可以进行大规模的ASCs提取、制备、储存,为再生医学提供种子细胞。 目前,国内、外缺乏ASCs提取、分离、制备及储存的标准和质量管理规范,导致各制备机构或研究应用机构之间无法进行统一的评估和交流,严重制约了ASCs在皮肤软组织修复重建等相关领域的发展。为了建立安全、规范、稳定、可追溯的行业共识、指南及标准,从源头保证ASCs的提取、制备、储存的高质性和安全性,中国医药生物技术协会皮肤软组织修复与重建技术分会联合从事细胞制备和存储、皮肤软组织修复重建、分子生物学及整形和美容外科等多学科的专家,参照中国医药生物技术协会《细胞库质量管理规范》及《干细胞制剂制备质量管理自律规范》,组织起草对脂肪组织的采集、ASCs 制备、检测、储存的标准和质量管理的专家共识,旨在促进ASCs在皮肤软组织修复重建技术等领域研究成果的转化,进一步促进多学科的交流和发展。

拓展指南:脂肪相关指南:

相关资料下载:
[AttachmentFileName(sort=100, fileName=脂肪组织来源的干细胞提取、制备及储存质量管理专家共识)] GetToolGuiderByIdResponse(projectId=1, id=b30451c0016580e9, title=脂肪组织来源的干细胞提取、制备及储存质量管理专家共识, enTitle=, guiderFrom=解放军医学杂志.2018,43(10)811-815., authorId=null, author=, summary=脂肪组织来源的干细胞(adipose tissue-derived stromal/stem cells,ASCs)是从脂肪组织中分离提取得到的,具有取材容易、对机体损伤小、体内储备量大、体外可大规模培养、多向分化潜能等优点。ASCs在人体修复重建、免疫调节及组织再生等方面的应用成为近年来干细胞储存的重要内容,也是组织工程及再生医学的研究热点。 大量研究表明,自体脂肪组织移植到软组织缺损部位后,其, cover=, journalId=null, articlesId=null, associationId=1716, associationName=中国医药生物技术协会 皮肤软组织修复与重建技术分会, associationIntro=, copyright=0, guiderPublishedTime=Mon Oct 01 00:00:00 CST 2018, originalUrl=, linkOutUrl=, content=<div>脂肪组织来源的干细胞(adipose tissue-derived stromal/stem cells,ASCs)是从脂肪组织中分离提取得到的,具有取材容易、对机体损伤小、体内储备量大、体外可大规模培养、多向分化潜能等优点。ASCs在人体修复重建、免疫调节及组织再生等方面的应用成为近年来干细胞储存的重要内容,也是组织工程及再生医学的研究热点。 大量研究表明,自体脂肪组织移植到软组织缺损部位后,其中40%~60%会被吸收,自体脂肪组织结合ASCs移植,能明显减少自体脂肪组织移植的吸收、液化、坏死及纤维化等情况的发生,构建具有生物学结构和功能的脂肪组织,同时,利用提取脂肪组织可以进行大规模的ASCs提取、制备、储存,为再生医学提供种子细胞。 目前,国内、外缺乏ASCs提取、分离、制备及储存的标准和质量管理规范,导致各制备机构或研究应用机构之间无法进行统一的评估和交流,严重制约了ASCs在皮肤软组织修复重建等相关领域的发展。为了建立安全、规范、稳定、可追溯的行业共识、指南及标准,从源头保证ASCs的提取、制备、储存的高质性和安全性,中国医药生物技术协会皮肤软组织修复与重建技术分会联合从事细胞制备和存储、皮肤软组织修复重建、分子生物学及整形和美容外科等多学科的专家,参照中国医药生物技术协会《细胞库质量管理规范》及《干细胞制剂制备质量管理自律规范》,组织起草对脂肪组织的采集、ASCs 制备、检测、储存的标准和质量管理的专家共识,旨在促进ASCs在皮肤软组织修复重建技术等领域研究成果的转化,进一步促进多学科的交流和发展。</div> <div><br> </div>拓展指南:<strong>与<font color="red">脂肪</font>相关指南:</strong><br><ul><li><a title="2018 国际肝移植共识声明:非酒精性脂肪性肝炎和肝移植引起的终末期肝病" target="_blank" href="http://www.medsci.cn/guideline/show_article.do?id=0d14e1c00163a216">2018 国际肝移植共识声明:非酒精性脂肪性肝炎和肝移植引起的终末期肝病</a></li> <li><a title="儿童非酒精性脂肪肝病诊断与治疗专家共识" target="_blank" href="http://www.medsci.cn/guideline/show_article.do?id=640e11c001622579">儿童非酒精性脂肪肝病诊断与治疗专家共识</a></li> <li><a title="非酒精性脂肪性肝病防治指南(2018更新版)" target="_blank" href="http://www.medsci.cn/guideline/show_article.do?id=9da6b1c0015ea6de">非酒精性脂肪性肝病防治指南(2018更新版)</a></li> <li><a title="2018 成人非酒精性脂肪性肝病预防和管理的饮食建议" target="_blank" href="http://www.medsci.cn/guideline/show_article.do?id=f2dfa1c0015595d9">2018 成人非酒精性脂肪性肝病预防和管理的饮食建议</a></li> <li><a title="非酒精性脂肪性肝病中西医结合诊疗共识意见(2017年)" target="_blank" href="http://www.medsci.cn/guideline/show_article.do?id=462051c0015331f9">非酒精性脂肪性肝病中西医结合诊疗共识意见(2017年)</a></li> 更多信息请点击:<a target="_blank" href="http://www.medsci.cn/guideline/list.do?q=%E8%84%82%E8%82%AA">有关脂肪更多指南</a></ul>, tagList=[TagDto(tagId=82416, tagName=脂肪组织来源的干细胞)], categoryList=[CategoryDto(categoryId=28, categoryName=整形科, tenant=100), CategoryDto(categoryId=21100, categoryName=达仁堂循证e学界, tenant=100)], articleKeywordId=null, articleKeyword=null, articleKeywordNum=null, guiderKeywordId=null, guiderKeyword=null, guiderKeywordNum=null, haveAttachments=1, attachmentList=null, guiderType=0, guiderArea=共识, guiderLanguage=1, guiderRegion=3, opened=0, paymentType=null, paymentAmount=10, recommend=0, recommendEndTime=null, sticky=0, stickyEndTime=null, allHits=15852, appHits=171, showAppHits=0, pcHits=10766, showPcHits=5671, likes=126, shares=10, comments=6, approvalStatus=1, publishedTime=Wed Oct 31 19:29:45 CST 2018, publishedTimeString=2018-10-01, pcVisible=1, appVisible=1, editorId=2020535, editor=qiushida2, waterMark=0, formatted=0, memberCards=[], isPrivilege=0, deleted=0, version=1, createdBy=null, createdName=qiushida2, createdTime=Wed Oct 31 19:29:45 CST 2018, updatedBy=null, updatedName=null, updatedTime=Sat Jan 06 18:53:45 CST 2024, courseDetails=[], otherVersionGuiders=[], isGuiderMember=false, ipAttribution=, attachmentFileNameList=[AttachmentFileName(sort=100, fileName=脂肪组织来源的干细胞提取、制备及储存质量管理专家共识)])
脂肪组织来源的干细胞提取、制备及储存质量管理专家共识
下载请点击:
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=900418, encodeId=f3d5900418e3, content=谢谢分享, beContent=null, objectType=guider, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=927d5267470, createdName=1481627fm11暂无昵称, createdTime=Thu Nov 19 10:53:11 CST 2020, time=2020-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351155, encodeId=6db1351155c8, content=了解一下谢谢, beContent=null, objectType=guider, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Thu Nov 01 08:51:28 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351114, encodeId=768c351114d1, content=谢谢分享, beContent=null, objectType=guider, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K46ZAxBHmHsph32KkfsWGwmickB6RsCUD8KruE4vo5CpvXfdu16GBpp4ibh6WJu1o9iatP1LWKDmvmic/0, createdBy=be6f1940165, createdName=1e0ece0dm09(暂无匿称), createdTime=Wed Oct 31 23:33:14 CST 2018, time=2018-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351107, encodeId=7a1a35110ef7, content=不错的文章值得拥有, beContent=null, objectType=guider, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Wed Oct 31 23:26:02 CST 2018, time=2018-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351084, encodeId=9788351084ce, content=学习了, beContent=null, objectType=guider, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Wed Oct 31 22:19:55 CST 2018, time=2018-10-31, status=1, ipAttribution=)]
    2020-11-19 1481627fm11暂无昵称

    谢谢分享

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=900418, encodeId=f3d5900418e3, content=谢谢分享, beContent=null, objectType=guider, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=927d5267470, createdName=1481627fm11暂无昵称, createdTime=Thu Nov 19 10:53:11 CST 2020, time=2020-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351155, encodeId=6db1351155c8, content=了解一下谢谢, beContent=null, objectType=guider, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Thu Nov 01 08:51:28 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351114, encodeId=768c351114d1, content=谢谢分享, beContent=null, objectType=guider, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K46ZAxBHmHsph32KkfsWGwmickB6RsCUD8KruE4vo5CpvXfdu16GBpp4ibh6WJu1o9iatP1LWKDmvmic/0, createdBy=be6f1940165, createdName=1e0ece0dm09(暂无匿称), createdTime=Wed Oct 31 23:33:14 CST 2018, time=2018-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351107, encodeId=7a1a35110ef7, content=不错的文章值得拥有, beContent=null, objectType=guider, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Wed Oct 31 23:26:02 CST 2018, time=2018-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351084, encodeId=9788351084ce, content=学习了, beContent=null, objectType=guider, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Wed Oct 31 22:19:55 CST 2018, time=2018-10-31, status=1, ipAttribution=)]
    2018-11-01 kafei

    了解一下谢谢

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=900418, encodeId=f3d5900418e3, content=谢谢分享, beContent=null, objectType=guider, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=927d5267470, createdName=1481627fm11暂无昵称, createdTime=Thu Nov 19 10:53:11 CST 2020, time=2020-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351155, encodeId=6db1351155c8, content=了解一下谢谢, beContent=null, objectType=guider, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Thu Nov 01 08:51:28 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351114, encodeId=768c351114d1, content=谢谢分享, beContent=null, objectType=guider, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K46ZAxBHmHsph32KkfsWGwmickB6RsCUD8KruE4vo5CpvXfdu16GBpp4ibh6WJu1o9iatP1LWKDmvmic/0, createdBy=be6f1940165, createdName=1e0ece0dm09(暂无匿称), createdTime=Wed Oct 31 23:33:14 CST 2018, time=2018-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351107, encodeId=7a1a35110ef7, content=不错的文章值得拥有, beContent=null, objectType=guider, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Wed Oct 31 23:26:02 CST 2018, time=2018-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351084, encodeId=9788351084ce, content=学习了, beContent=null, objectType=guider, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Wed Oct 31 22:19:55 CST 2018, time=2018-10-31, status=1, ipAttribution=)]
    2018-10-31 1e0ece0dm09(暂无匿称)

    谢谢分享

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=900418, encodeId=f3d5900418e3, content=谢谢分享, beContent=null, objectType=guider, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=927d5267470, createdName=1481627fm11暂无昵称, createdTime=Thu Nov 19 10:53:11 CST 2020, time=2020-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351155, encodeId=6db1351155c8, content=了解一下谢谢, beContent=null, objectType=guider, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Thu Nov 01 08:51:28 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351114, encodeId=768c351114d1, content=谢谢分享, beContent=null, objectType=guider, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K46ZAxBHmHsph32KkfsWGwmickB6RsCUD8KruE4vo5CpvXfdu16GBpp4ibh6WJu1o9iatP1LWKDmvmic/0, createdBy=be6f1940165, createdName=1e0ece0dm09(暂无匿称), createdTime=Wed Oct 31 23:33:14 CST 2018, time=2018-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351107, encodeId=7a1a35110ef7, content=不错的文章值得拥有, beContent=null, objectType=guider, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Wed Oct 31 23:26:02 CST 2018, time=2018-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351084, encodeId=9788351084ce, content=学习了, beContent=null, objectType=guider, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Wed Oct 31 22:19:55 CST 2018, time=2018-10-31, status=1, ipAttribution=)]
    2018-10-31 1e1b8538m79(暂无匿称)

    不错的文章值得拥有

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=900418, encodeId=f3d5900418e3, content=谢谢分享, beContent=null, objectType=guider, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=927d5267470, createdName=1481627fm11暂无昵称, createdTime=Thu Nov 19 10:53:11 CST 2020, time=2020-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351155, encodeId=6db1351155c8, content=了解一下谢谢, beContent=null, objectType=guider, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Thu Nov 01 08:51:28 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351114, encodeId=768c351114d1, content=谢谢分享, beContent=null, objectType=guider, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K46ZAxBHmHsph32KkfsWGwmickB6RsCUD8KruE4vo5CpvXfdu16GBpp4ibh6WJu1o9iatP1LWKDmvmic/0, createdBy=be6f1940165, createdName=1e0ece0dm09(暂无匿称), createdTime=Wed Oct 31 23:33:14 CST 2018, time=2018-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351107, encodeId=7a1a35110ef7, content=不错的文章值得拥有, beContent=null, objectType=guider, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Wed Oct 31 23:26:02 CST 2018, time=2018-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=351084, encodeId=9788351084ce, content=学习了, beContent=null, objectType=guider, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Wed Oct 31 22:19:55 CST 2018, time=2018-10-31, status=1, ipAttribution=)]
    2018-10-31 医者仁心5538

    学习了

    0