多黏菌素药物敏感性检测及临床解读专家共识

2020-09-01 中国医学科学院北京协和医学院 协和医学杂志

本共识对多黏菌素药物敏感性试验方法及结果进行规范解读, 并提出相应建议。

中文标题:

多黏菌素药物敏感性检测及临床解读专家共识

发布日期:

2020-09-01

简要介绍:

多黏菌素是耐药革兰阴性杆菌的重要治疗药物。2020年美国临床和实验室标准协会变更了多黏菌素药物敏感性折点取消了多黏菌素敏感折点仅报告中介(I≤2mg/L)与耐药(R≥4mg/L), 而欧洲抗菌药物敏感性试验委员会则建议采用敏感 (S≤2mg/L)、耐药 (R>2mg/L)作为临床折点多黏菌素药物敏感性试验的操作难度以及国际药物敏感性折点的不统一给国内临床实验室一线人员带来极大困扰。因此,如何精准开展多黏菌素药物敏感性检测,规范其报告解读是当前国内抗菌药物应用和抗感染领域亟待解决的问题。本共识对多黏菌素药物敏感性试验方法及结果进行规范解读并提出相应建议

相关资料下载:
[AttachmentFileName(sort=1, fileName=多黏菌素药物敏感性检测及临床解读专家共识_杨启文.pdf)] GetToolGuiderByIdResponse(projectId=1, id=1c3de1c002e0691a, title=多黏菌素药物敏感性检测及临床解读专家共识, enTitle=, guiderFrom=协和医学杂志, authorId=0, author=, summary=本共识对多黏菌素药物敏感性试验方法及结果进行规范解读, 并提出相应建议。, cover=https://img.medsci.cn/Random/116.jpg, journalId=0, articlesId=null, associationId=2420, associationName=中国医学科学院北京协和医学院, associationIntro=中国医学科学院北京协和医学院, copyright=0, guiderPublishedTime=Tue Sep 01 00:00:00 CST 2020, originalUrl=, linkOutUrl=, content=<p><span class="fontstyle0">多黏菌素是耐药革兰阴性杆菌的重要治疗药物</span><span class="fontstyle1">。2020</span><span class="fontstyle0">年美国临床和实验室标准协会变更了多黏菌素药物敏感性折点</span><span class="fontstyle1">,</span><span class="fontstyle0">取消了多黏菌素敏感折点</span><span class="fontstyle1">,</span><span class="fontstyle0">仅报告中介(</span><span class="fontstyle1">I&le;2mg/L)</span><span class="fontstyle0">与耐药</span><span class="fontstyle1">(R&ge;4mg/L), </span><span class="fontstyle0">而欧洲抗菌药物敏感性试验委员会则建议采用敏感 (</span><span class="fontstyle1">S&le;2mg/L)、</span><span class="fontstyle0">耐药 (</span><span class="fontstyle1">R&gt;2mg/L)</span><span class="fontstyle0">作为临床折点</span><span class="fontstyle1">。 </span><span class="fontstyle0">多黏菌素药物敏感性试验的操作难度以及国际药物敏感性折点的不统一给国内临床实验室一线人员带来极大困扰。</span><span class="fontstyle0">因此,</span><span class="fontstyle0">如何精准开展多黏菌素药物敏感性检测,</span><span class="fontstyle0">规范其报告解读是当前国内抗菌药物应用和抗感染领域亟待解决的问题。</span><span class="fontstyle0">本共识对多黏菌素药物敏感性试验方法及结果进行规范解读</span><span class="fontstyle1">, </span><span class="fontstyle0">并提出相应建议</span><span class="fontstyle1">。</span></p>, tagList=[TagDto(tagId=73665, tagName=多黏菌素)], categoryList=[CategoryDto(categoryId=2, categoryName=心血管, tenant=100), CategoryDto(categoryId=4, categoryName=消化, tenant=100), CategoryDto(categoryId=5, categoryName=肿瘤, tenant=100), CategoryDto(categoryId=6, categoryName=内分泌, tenant=100), CategoryDto(categoryId=8, categoryName=糖尿病, tenant=100), CategoryDto(categoryId=9, categoryName=传染科, tenant=100), CategoryDto(categoryId=10, categoryName=骨科, tenant=100), CategoryDto(categoryId=11, categoryName=药械, tenant=100), CategoryDto(categoryId=12, categoryName=呼吸, tenant=100), CategoryDto(categoryId=14, categoryName=肾内科, tenant=100), CategoryDto(categoryId=15, categoryName=风湿免疫, tenant=100), CategoryDto(categoryId=17, categoryName=神经科, tenant=100), CategoryDto(categoryId=18, categoryName=儿科, tenant=100), CategoryDto(categoryId=19, categoryName=老年医学, tenant=100), CategoryDto(categoryId=21, categoryName=血液科, tenant=100), CategoryDto(categoryId=22, categoryName=肝病, tenant=100), CategoryDto(categoryId=23, categoryName=普通外科, tenant=100), CategoryDto(categoryId=24, categoryName=胸心外科, tenant=100), CategoryDto(categoryId=25, categoryName=神经外科, tenant=100), CategoryDto(categoryId=26, categoryName=泌尿外科, tenant=100), CategoryDto(categoryId=27, categoryName=烧伤科, tenant=100), CategoryDto(categoryId=28, categoryName=整形科, tenant=100), CategoryDto(categoryId=30, categoryName=耳鼻咽喉, tenant=100), CategoryDto(categoryId=31, categoryName=口腔科, tenant=100), CategoryDto(categoryId=32, categoryName=眼科, tenant=100), CategoryDto(categoryId=36, categoryName=妇产科, tenant=100), CategoryDto(categoryId=38, categoryName=急重症, tenant=100), CategoryDto(categoryId=39, categoryName=皮肤性病, tenant=100), CategoryDto(categoryId=43, categoryName=冠心病, tenant=100), CategoryDto(categoryId=66, categoryName=营养科, tenant=100), CategoryDto(categoryId=69, categoryName=检验病理, tenant=100), CategoryDto(categoryId=76, categoryName=胃肠外科, tenant=100), CategoryDto(categoryId=79, categoryName=护理, tenant=100), CategoryDto(categoryId=85, categoryName=指南&解读, tenant=100), CategoryDto(categoryId=89, categoryName=乳腺癌, tenant=100), CategoryDto(categoryId=91, categoryName=肝胆胰外, tenant=100), CategoryDto(categoryId=92, categoryName=血管外科, tenant=100), CategoryDto(categoryId=95, categoryName=康复医学, tenant=100), CategoryDto(categoryId=21100, categoryName=达仁堂循证e学界, tenant=100)], articleKeywordId=73665, articleKeyword=多黏菌素, articleKeywordNum=6, guiderKeywordId=73665, guiderKeyword=多黏菌素, guiderKeywordNum=6, haveAttachments=1, attachmentList=null, guiderType=0, guiderArea=共识, guiderLanguage=0, guiderRegion=3, opened=0, paymentType=, paymentAmount=10, recommend=0, recommendEndTime=null, sticky=0, stickyEndTime=null, allHits=112532, appHits=44, showAppHits=0, pcHits=366, showPcHits=112488, likes=0, shares=3, comments=2, approvalStatus=1, publishedTime=Tue Oct 11 16:21:00 CST 2022, publishedTimeString=2020-09-01, pcVisible=1, appVisible=1, editorId=0, editor=QIAN LIN, waterMark=0, formatted=0, memberCards=[], isPrivilege=0, deleted=0, version=9, createdBy=null, createdName=QIAN LIN, createdTime=Wed Oct 05 21:26:50 CST 2022, updatedBy=6459136, updatedName=玉在山, updatedTime=Fri Jan 05 23:41:36 CST 2024, courseDetails=[], otherVersionGuiders=[], isGuiderMember=false, ipAttribution=, attachmentFileNameList=[AttachmentFileName(sort=1, fileName=多黏菌素药物敏感性检测及临床解读专家共识_杨启文.pdf)])
多黏菌素药物敏感性检测及临床解读专家共识_杨启文.pdf
下载请点击:
评论区 (2)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2166123, encodeId=5ae12166123f9, content=<a href='/topic/show?id=f9dd43508f2' target=_blank style='color:#2F92EE;'>#多黏菌素#</a> , beContent=null, objectType=guider, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43508, encryptionId=f9dd43508f2, topicName=多黏菌素)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=1ff65466529, createdName=litao2022, createdTime=Wed Nov 01 15:10:00 CST 2023, time=2023-11-01, status=1, ipAttribution=上海), GetPortalCommentsPageByObjectIdResponse(id=2093193, encodeId=3379209319356, content=很棒,学习了, beContent=null, objectType=guider, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211110/a1093f9556844f29afef12001f490cf8/3c85211d07a6410dbddb9b338d63913f.jpg, createdBy=d1c85308255, createdName=陈弦, createdTime=Tue Oct 11 19:52:30 CST 2022, time=2022-10-11, status=1, ipAttribution=)]
    2023-11-01 litao2022 来自上海
  2. [GetPortalCommentsPageByObjectIdResponse(id=2166123, encodeId=5ae12166123f9, content=<a href='/topic/show?id=f9dd43508f2' target=_blank style='color:#2F92EE;'>#多黏菌素#</a> , beContent=null, objectType=guider, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43508, encryptionId=f9dd43508f2, topicName=多黏菌素)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=1ff65466529, createdName=litao2022, createdTime=Wed Nov 01 15:10:00 CST 2023, time=2023-11-01, status=1, ipAttribution=上海), GetPortalCommentsPageByObjectIdResponse(id=2093193, encodeId=3379209319356, content=很棒,学习了, beContent=null, objectType=guider, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211110/a1093f9556844f29afef12001f490cf8/3c85211d07a6410dbddb9b338d63913f.jpg, createdBy=d1c85308255, createdName=陈弦, createdTime=Tue Oct 11 19:52:30 CST 2022, time=2022-10-11, status=1, ipAttribution=)]
    2022-10-11 陈弦

    很棒,学习了

    0

拓展阅读

Ann Intensive Care:多黏菌素B血液灌注+血液滤过能为内毒素休克患者带来多大获益?

2018年12月,西班牙学者发表在《Ann Intensive Care》的一项病例对照研究,考察了血液滤过联合多粘菌素B血流灌注对内毒素休克患者的影响。

Lancet Infect Dis:多黏菌素+美罗培南能改善革兰阴性菌引起的严重感染吗?

2018年4月,发表于《Lancet Infect Dis》上的一项开放标签、随机临床试验,考察了治疗碳青霉烯类耐药的革兰阴性菌引起的严重感染:多黏菌素vs多黏菌素+美罗培南。

《注射用多黏菌素用于儿童的临床实践指南》计划书

山东第一医科大学附属省立医院药学部 · 2023-11-15