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肾衰临床试验结局的国际共识2020

2020-10-19 Kidney Int . 2020 Oct;98(4):849-859.

肾衰肾衰竭

肾衰竭对于患者，临床医生，研究人员，医疗系统，付款人和监管者而言都是重要的结果。但是，尚无专门针对临床试验的统一的国际公认的肾衰竭定义和进展为肾衰竭的关键替代指标。国际肾脏病学会召开了一次国际多方利益

中文标题：

肾衰临床试验结局的国际共识2020

英文标题：

International consensus definitions of clinical trial outcomes for kidney failure: 2020

发布机构：

发布日期：

2020-10-19

简要介绍：

肾衰竭对于患者，临床医生，研究人员，医疗系统，付款人和监管者而言都是重要的结果。但是，尚无专门针对临床试验的统一的国际公认的肾衰竭定义和进展为肾衰竭的关键替代指标。国际肾脏病学会召开了一次国际多方利益相关者会议，以就该话题达成共识。一个在临床试验的设计，进行和结果判断方面经验丰富的核心小组开发了一个包含64个随机试验的数据库，其中的163个包括与肾衰竭有关的定义。通过迭代过程，制定了一套提议的共识定义，随后由代表18个不同国家的83个参与者组成的更大的多利益相关方小组进行了审查。与会人员的共识是，临床试验肾衰竭的结果应包括复合材料，其中包括接受肾移植，开始维持性透析和因肾衰竭死亡。它还可能包括仅基于实验室测量的肾小球滤过率的结果：持续的低肾小球滤过率和持续的肾小球滤过率下降百分比。讨论包括重要的考虑因素，例如（i）认识现有的肾衰竭命名法； （ii）跨资源设置的适用性； （iii）使所有利益相关者易于理解； （iv）避免不当的复杂性，以便可以在各种人群和试验方法中使用这些定义。最终定义反映了在临床试验中使用的共识。

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    2022-09-14 ms6000001079376731

    学习了！

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    2021-12-24 ms5000001744147716

    学习了👍🏻

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    2021-12-24 ms5000001744147716

    学习了

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    2021-05-04 ms6000000439136942

    积极学习💪

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    2020-11-04 ms7843271761986680

    学习了

    0