结直肠癌免疫治疗专家共识

2020-10-01 中国临床肿瘤学会 Cancer Commun (Lond) . 2020 Oct;40(10):467-472.

随着免疫检查点抑制剂(ICIs)在过去数十年的快速发展,免疫治疗已经成为CRC治疗的研究热点

中文标题:

结直肠癌免疫治疗专家共识

英文标题:

Expert opinions on immunotherapy for patients with colorectal cancer

发布机构:

中国临床肿瘤学会

发布日期:

2020-10-01

简要介绍:

随着免疫检查点抑制剂(ICIs)在过去数十年的快速发展,免疫治疗已经成为CRC治疗的研究热点[1,2]。证据表明,抗PD-1药物单独应用或联合抗CTLA-4治疗可以在错配修复缺陷(dMMR)或高度微卫星不稳定(MSI-H)的转移性CRC(mCRC)患者中获得持久应答。然而,此类dMMR/MSI-H患者的最佳诊断方法和抗PD-1为基础的最佳治疗模式还存在争议。且大多数mCRC病例为错配修复完整(pMMR)或微卫星稳定(MSS),免疫药物的临床获益有限,需要研究对此类患者有效的联合治疗方案。此外,抗PD-1为基础的治疗在非转移性CRC中的研究已经开始,并取得了令人鼓舞的初步证据[8]。2020年6月16日,来自中国临床肿瘤学会结直肠癌委员会的肿瘤内科医生和外科医生于在中国广州进行了结直肠癌免疫治疗专家讨论会,将专家共识和相关临床证据进行总结,以指导真实世界中ICIs用于CRC患者的治疗决策。

 

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    2022-05-13 ms6634190591642810

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    2022-04-23 ms3000000771933475

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    2022-03-25 ms6980619036574494

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    2022-03-13 sutianshi

    学习了

    0

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    2022-01-10 撑撑

    积分可以关注梅斯医学公众号,回复积分,能免费领100个。。。。只能帮你到这了

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