2014 美国免疫缺陷基金会：免疫缺陷患者及其接触者接种活病毒细菌疫苗推荐意见

中文标题：

2014 美国免疫缺陷基金会：免疫缺陷患者及其接触者接种活病毒细菌疫苗推荐意见

英文标题：

Recommendations for live viral and bacterial vaccines in immunodeficient patients and their close contacts

发布机构：

美国免疫缺陷基金会

发布日期：

2014-02-28

简要介绍：

The present uncertainty of which live viral or bacterialvaccinescan be given to immunodeficient patients and the growing neglect of societal adherence to routine immunizations has prompted the Medical Advisory Committee of the Immune Deficiency Foundation to issuerecommendationsbased on published literature and the collective experience of the committee members. Theserecommendationsaddress the concern for immunodeficient patients acquiring infections from healthy subjects who have not been immunized or who are shedding livevaccine-derived viral or bacterial organisms. Such transmission of infectious agents can occur within the hospital, clinic, or home or at any public gathering. Collectively, we define this type of transmission as close-contact spread of infectious disease that is particularly relevant in patients with impaired immunity who might have an infection when exposed to subjects carryingvaccine-preventable infectious diseases or who have recently received a livevaccine. Immunodeficient patients who have received therapeutic hematopoietic stem transplantation are also at risk during the time when immune reconstitution is incomplete or while they are receiving immunosuppressive agents to prevent or treat graft-versus-host disease. This review recommends the general education of what is known aboutvaccine-preventable orvaccine-derived diseases being spread to immunodeficient patients at risk for close-contact spread of infection and describes the relative risks for a child with severe immunodeficiency. The review also recommends a balance between the need to protect vulnerable subjects and their social needs to integrate into society, attend school, and benefit from peer education.

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