药物性肝损伤基层诊疗指南(实践版·2019)

2020-10-19 中华医学会 中华全科医师杂志.2020,19(10):876-881.

在药物使用过程中,因药物本身和/或其代谢产物导致,或由于特殊体质对药物的超敏感性或耐受性降低所导致的肝脏损伤称为药物性肝损伤(drug‐induced liver injury,DILI),亦称药物性

中文标题:

药物性肝损伤基层诊疗指南(实践版·2019)

发布机构:

中华医学会

发布日期:

2020-10-19

简要介绍:

在药物使用过程中,因药物本身和/或其代谢产物导致,或由于特殊体质对药物的超敏感性或耐受性降低所导致的肝脏损伤称为药物性肝损伤(drug‐induced liver injury,DILI),亦称药物性肝病,是最常见和最严重的药物不良反应(ADR)之一。临床上可表现为各种急慢性肝病,轻者停药后自行恢复,重者危及生命。目前明确引起DILI的药物超过1 000种,DILI占非病毒性肝病的20%~50%,暴发性肝衰竭的13%~30%,发达国家患病率为1/10万~20/10万。国内尚未有全国性的流行病学调查。根据我国一项多中心大型回顾性研究报告,我国普通人群DILI的年发病率为23.80/10万,高于西方国家的报告。我国急性DILI的诊断病例逐年上升,传统中草药和膳食添加以及抗结核药是我国DILI的主要原因。DILI已成为一个不容忽视的严重公共卫生问题。

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    2021-09-21 ms5000001790698188

    学习啦

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1053537, encodeId=99ae105353e6d, content=学习啦, beContent=null, objectType=guider, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210821/09cb83fb3815478d92482d68d1ed7247/3910ce82cfcb4d98bd530b29f615e391.jpg, createdBy=f82d5567322, createdName=ms5000001790698188, createdTime=Tue Sep 21 17:22:36 CST 2021, time=2021-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1011699, encodeId=ff551011699b0, content=非常好, beContent=null, objectType=guider, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a48d5569851, createdName=ms3000001000063264, createdTime=Thu Aug 26 14:02:23 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967189, encodeId=625096e1894c, content=药物性肝损伤的诊断可以作为药物性肝炎的诊断吗?, beContent=null, objectType=guider, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210519/b5004736a51248239bb3eebca364abe2/680ddea9b83b4e21bc66ff4c5a8d6560.jpg, createdBy=6eff5504812, createdName=暴走阳, createdTime=Thu May 20 11:08:58 CST 2021, time=2021-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951522, encodeId=1ca695152285, content=很好, beContent=null, objectType=guider, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/6yNxBXT4JYjZW1IQ3cobmBdIZeBS3URH8QFdMicNs89PwCT8QOTUdtiakoLp2c6vRyqnicLPV4jsEuQbUEyuuIy8g/132, createdBy=0b712392119, createdName=zsl00, createdTime=Sat Mar 27 07:53:21 CST 2021, time=2021-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950788, encodeId=ddc1950e8889, content=<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>很好, beContent=null, objectType=guider, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c975456358, createdName=ms1000000686260508, createdTime=Wed Mar 24 17:37:15 CST 2021, time=2021-03-24, status=1, ipAttribution=)]
    2021-08-26 ms3000001000063264

    非常好

    0

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    2021-05-20 暴走阳

    药物性肝损伤的诊断可以作为药物性肝炎的诊断吗?

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1053537, encodeId=99ae105353e6d, content=学习啦, beContent=null, objectType=guider, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210821/09cb83fb3815478d92482d68d1ed7247/3910ce82cfcb4d98bd530b29f615e391.jpg, createdBy=f82d5567322, createdName=ms5000001790698188, createdTime=Tue Sep 21 17:22:36 CST 2021, time=2021-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1011699, encodeId=ff551011699b0, content=非常好, beContent=null, objectType=guider, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a48d5569851, createdName=ms3000001000063264, createdTime=Thu Aug 26 14:02:23 CST 2021, time=2021-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=967189, encodeId=625096e1894c, content=药物性肝损伤的诊断可以作为药物性肝炎的诊断吗?, beContent=null, objectType=guider, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210519/b5004736a51248239bb3eebca364abe2/680ddea9b83b4e21bc66ff4c5a8d6560.jpg, createdBy=6eff5504812, createdName=暴走阳, createdTime=Thu May 20 11:08:58 CST 2021, time=2021-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951522, encodeId=1ca695152285, content=很好, beContent=null, objectType=guider, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/6yNxBXT4JYjZW1IQ3cobmBdIZeBS3URH8QFdMicNs89PwCT8QOTUdtiakoLp2c6vRyqnicLPV4jsEuQbUEyuuIy8g/132, createdBy=0b712392119, createdName=zsl00, createdTime=Sat Mar 27 07:53:21 CST 2021, time=2021-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950788, encodeId=ddc1950e8889, content=<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>很好, beContent=null, objectType=guider, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c975456358, createdName=ms1000000686260508, createdTime=Wed Mar 24 17:37:15 CST 2021, time=2021-03-24, status=1, ipAttribution=)]
    2021-03-27 zsl00

    很好

    0

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    2021-03-24 ms1000000686260508

    #学习#很好

    0

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