谷氨酰胺在危重症患者中临床应用的专家推荐意见(节录)

2016-11-30 营养学报.2016,38(5):421-426.

谷氨酰胺(glutamine,GLN)作为人体氨基酸之一,广泛地参与机体的各种生物活动。正常生理状况下,机体肌肉组织中的谷氨酰胺合成酶自身合成GLN。

中文标题:

谷氨酰胺在危重症患者中临床应用的专家推荐意见(节录)

发布机构:

发布日期:

2016-11-30

简要介绍:

谷氨酰胺(glutamine,GLN)作为人体氨基酸之一,广泛地参与机体的各种生物活动。正常生理状况下,机体肌肉组织中的谷氨酰胺合成酶自身合成GLN。但当机体处于全身炎性反应、创伤及大手术等危重状态时,GLN 参与多种应激反应过程,而自身合成的GLN 却无法满足机体所需,须额外补充,因此GLN 是一种重要的条件必需氨基酸。研究表明,在危重症状况下,适宜的GLN 供给对于维持正常肠屏障功能、降低炎性介质水平是必需的[1]。但最近也有一些重要的质疑性研究,对GLN 的临床应用引起不同意见的争论。随着循证医学的发展,临床工作也越来越重视随机对照试验(RCT)的作用。但是,应该警惕将一些设计有重大缺陷的大样本RCT,以及将由此得出的循证系统评价当成“高等级证据”,这一危险倾向,将严重误导临床工作。与此同时,应注意临床营养研究与药物验证研究存在很大差别,即在临床研究中,营养干预措施是综合性的,如不深入细致地对能量、蛋白质与其他营养素摄入量、输注途径及输注技术等方面进行严格管理,将导致严重的不良后果。


制定者:中国营养学会临床营养分会
拓展指南:谷氨酰胺相关指南:

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谷氨酰胺在危重症患者中临床应用的专家推荐意见(节录)
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    2022-03-30 洁巴子

    学习了

    0

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    2017-07-09 日月生辉

    学习了,很有用

    0

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    2017-05-06 李九思

    学习了就有收获。

    0

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    2016-12-20 thlabcde

    学习了好东西!

    0

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    2016-12-18 thlabcde

    学习了好东西!

    0