2010 EFNS 阿尔茨海默病的诊断和处理指南

中文标题：

2010 EFNS 阿尔茨海默病的诊断和处理指南

英文标题：

2010 EFNS guidelines for the diagnosis and management of Alzheimer's disease

发布机构：

欧洲神经科学协会联盟

发布日期：

2010-10-01

简要介绍：

Background and objectives: In 2008 a task force was set up to develop a revision of theEuropean Federation of the Neurological Societies (EFNS) guideline for the diagnosisand management of Alzheimers disease (AD) and other disorders associated withdementia, published in early 2007. The aim of this revised international guideline wasto present a peer-reviewed evidence-based statement for the guidance of practice forclinical neurologists, geriatricians, psychiatrists, and other specialist physiciansresponsible for the care of patients with AD. Mild cognitive impairment and nonAlzheimer dementias are not included in this guideline.Methods: The task force working group reviewed evidence from original researcharticles, meta-analysis, and systematic reviews, published before May 2009. The evidence was classified and consensus recommendations graded (A, B, or C) according tothe EFNS guidance. Where there was a lack of evidence, but clear consensus, goodpractice points were provided.Results: The recommendations for clinical diagnosis, blood tests, neuropsychology,neuroimaging, electroencephalography, cerebrospinal fluid (CSF) analysis, genetictesting, disclosure of diagnosis, treatment of AD, behavioural and psychologicalsymptoms in dementia, legal issues, counselling and support for caregivers were allrevised as compared with the previous EFNS guideline.Conclusion: A number of new recommendations and good practice points are made,namely in CSF, neuropsychology, neuroimaging and reviewing non-evidence basedtherapies. The assessment, interpretation, and treatment of symptoms, disability,needs, and caregiver stress during the course of AD require the contribution of manydifferent professionals. These professionals should adhere to these guideline toimprove the diagnosis and management of AD