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The integration of T cell migration, differentiation and function.
Masopust D, Schenkel JM. Masopust D, et al. Nat Rev Immunol. 2013 May;13(5):309-20. doi: 10.1038/nri3442. Epub 2013 Apr 19. Nat Rev Immunol. 2013. PMID: 23598650 Review.
Recent discoveries revise our understanding of the regulation and patterns of T cell trafficking and reveal limitations in current paradigms. Here, we review classic and emerging concepts, highlight the challenge of integrating new observations with existing T cell classif …
Recent discoveries revise our understanding of the regulation and patterns of T cell trafficking and reveal limitations in current pa …
Immunological considerations for COVID-19 vaccine strategies.
Jeyanathan M, Afkhami S, Smaill F, Miller MS, Lichty BD, Xing Z. Jeyanathan M, et al. Nat Rev Immunol. 2020 Oct;20(10):615-632. doi: 10.1038/s41577-020-00434-6. Epub 2020 Sep 4. Nat Rev Immunol. 2020. PMID: 32887954 Free PMC article. Review.
Here, we discuss the immunological principles that need to be taken into consideration in the development of COVID-19 vaccine strategies. On the basis of these principles, we examine the current COVID-19 vaccine candidates, their strengths and potential shortfalls, and mak …
Here, we discuss the immunological principles that need to be taken into consideration in the development of COVID-19 vaccine strategies. On …
Moving tuberculosis vaccines from theory to practice.
Andersen P, Scriba TJ. Andersen P, et al. Nat Rev Immunol. 2019 Sep;19(9):550-562. doi: 10.1038/s41577-019-0174-z. Nat Rev Immunol. 2019. PMID: 31114037 Review.
Breakthrough findings in both the basic immunology of Mycobacterium tuberculosis infection and the clinical development of TB vaccines suggest, for the first time since the discovery of the Mycobacterium bovis bacillus Calmette-Guerin (BCG) vaccine more than a century ago, that a …
Breakthrough findings in both the basic immunology of Mycobacterium tuberculosis infection and the clinical development of TB vaccines sugge …
GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches.
Lang FM, Lee KM, Teijaro JR, Becher B, Hamilton JA. Lang FM, et al. Nat Rev Immunol. 2020 Aug;20(8):507-514. doi: 10.1038/s41577-020-0357-7. Epub 2020 Jun 23. Nat Rev Immunol. 2020. PMID: 32576980 Free PMC article. Review.
Granulocyte-macrophage colony-stimulating factor (GM-CSF), a myelopoietic growth factor and pro-inflammatory cytokine, plays a critical role in alveolar macrophage homeostasis, lung inflammation and immunological disease. Both administration and inhibition of GM-CSF are curren …
Granulocyte-macrophage colony-stimulating factor (GM-CSF), a myelopoietic growth factor and pro-inflammatory cytokine, plays a critical role …
COVID-19 herd immunity: where are we?
Fontanet A, Cauchemez S. Fontanet A, et al. Nat Rev Immunol. 2020 Oct;20(10):583-584. doi: 10.1038/s41577-020-00451-5. Nat Rev Immunol. 2020. PMID: 32908300 Free PMC article.
It states that only a proportion of a population needs to be immune (through overcoming natural infection or through vaccination) to an infectious agent for it to stop generating large outbreaks. A key question in the current COVID-19 pandemic is how and when herd immunity …
It states that only a proportion of a population needs to be immune (through overcoming natural infection or through vaccination) to an infe …