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1-Boc-Piperidine-4-Carboxaldehyde Prevents Binge-Eating Behaviour and Anxiety in Rats.
Guzmán-Rodríguez S, Chávez-Reyes J, Vázquez-León P, Soriano-Ursúa MA, Rosalez MN, Allende G, Marichal-Cancino BA. Guzmán-Rodríguez S, et al. Pharmacology. 2021;106(5-6):305-315. doi: 10.1159/000513376. Epub 2021 Mar 23. Pharmacology. 2021. PMID: 33756489
BACKGROUND: Piperidines are biogenic amines studied mainly in toxicology because they were initially found as alkaloids from peppers and insect venoms. ...In experimental protocol 2, mildly stressed animals were evaluated in the elevated plus maze under the acute effects o …
BACKGROUND: Piperidines are biogenic amines studied mainly in toxicology because they were initially found as alkaloids from peppers …
Comparison of four different colorimetric and fluorometric cytotoxicity assays in a zebrafish liver cell line.
Bopp SK, Lettieri T. Bopp SK, et al. BMC Pharmacol. 2008 May 30;8:8. doi: 10.1186/1471-2210-8-8. BMC Pharmacol. 2008. PMID: 18513395 Free PMC article.
BACKGROUND: A broad spectrum of cytotoxicity assays is currently used in the fields of (eco)toxicology and pharmacology. To choose an appropriate assay, different parameters like test compounds, detection mechanism, specificity, and sensitivity have to be considered. ...CO …
BACKGROUND: A broad spectrum of cytotoxicity assays is currently used in the fields of (eco)toxicology and pharmacology. To choose an …
The effect of formulation vehicles on the in vitro percutaneous permeation of ibuprofen.
Stahl J, Wohlert M, Kietzmann M. Stahl J, et al. BMC Pharmacol. 2011 Dec 14;11:12. doi: 10.1186/1471-2210-11-12. BMC Pharmacol. 2011. PMID: 22168832 Free PMC article.
A significant shorter lagtime was found after gel treatment compared with the cream and the solution. After 28 hours 59% of the applied ibuprofen was found in the receptor fluid of the cream treated samples, 26% in the solution treated samples and 21% in the samples treate …
A significant shorter lagtime was found after gel treatment compared with the cream and the solution. After 28 hours 59% of the applied …
Inhibition of K+ channels and stimulation of insulin secretion by the sulfonylurea, glimepiride, in relation to its membrane binding in pancreatic islets.
Schwanstecher M, Mnner K, Panten U. Schwanstecher M, et al. Pharmacology. 1994 Aug;49(2):105-11. doi: 10.1159/000139222. Pharmacology. 1994. PMID: 7972319
Determination of albumin binding revealed that the free glimepiride and glibenclamide concentrations applied in our investigation were in the range of therapeutic serum concentrations of the free drugs. ...
Determination of albumin binding revealed that the free glimepiride and glibenclamide concentrations applied in our investigation wer …
Oxidative protein damage with carbonyl levels and nitrotyrosine expression after chemotherapy in bone marrow transplantation patients.
Sabuncuoğlu S, Öztaş Y, Çetinkaya DU, Özgüneş N, Özgüneş H. Sabuncuoğlu S, et al. Pharmacology. 2012;89(5-6):283-6. doi: 10.1159/000337040. Pharmacology. 2012. PMID: 22538733 Clinical Trial.
In accordance, the mean plasma carbonyl levels on days 14 and 28 were significantly higher than on the other days. High dose chemotherapy applied in the preparative regimen of HSCT may be responsible for this long-term oxidation of plasma proteins. ...
In accordance, the mean plasma carbonyl levels on days 14 and 28 were significantly higher than on the other days. High dose chemotherapy …
Effects of first and second generation antihistamines on muscarinic induced mucus gland cell ion transport.
Liu H, Farley JM. Liu H, et al. BMC Pharmacol. 2005 Mar 24;5:8. doi: 10.1186/1471-2210-5-8. BMC Pharmacol. 2005. PMID: 15790419 Free PMC article.
Transport of ions, as short-circuit current measured under voltage-clamp, was measured in response to acetylcholine (ACh) or histamine applied to the serosal side of the gland cell layers. Concentration-response relationships for ACh or histamine were generated in the pres …
Transport of ions, as short-circuit current measured under voltage-clamp, was measured in response to acetylcholine (ACh) or histamine ap …
Lisuride acts at multiple sites to induce ocular hypotension and mydriasis.
Potter DE, Ogidigben MJ, Chu TC. Potter DE, et al. Pharmacology. 1998 Nov;57(5):249-60. doi: 10.1159/000028249. Pharmacology. 1998. PMID: 9742290
Topically unilaterally applied lisuride caused dose-related lowering of intraocular pressure in ipsilateral (treated) but not in contralateral eyes of normal rabbits. ...
Topically unilaterally applied lisuride caused dose-related lowering of intraocular pressure in ipsilateral (treated) but not in cont …