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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 7
1995 47
1996 57
1997 47
1998 49
1999 55
2000 59
2001 67
2002 67
2003 18
2004 12
2005 6
2006 34
2007 49
2008 69
2009 36
2010 65
2011 109
2012 114
2013 47
2014 40
2015 87
2016 52
2017 24
2018 49
2019 39
2020 71
2021 119
2022 115
2023 119
2024 33

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1,706 results

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Page 1
Reversal of angiotensin ll-induced β-cell dedifferentiation via inhibition of NF-κb signaling.
Chen H, Zhou W, Ruan Y, Yang L, Xu N, Chen R, Yang R, Sun J, Zhang Z. Chen H, et al. Mol Med. 2018 Aug 14;24(1):43. doi: 10.1186/s10020-018-0044-3. Mol Med. 2018. PMID: 30134927 Free PMC article.
Mechanistically, Angll induced beta-cell dedifferentiation via NF-kappab signaling, while treatment with lrbesartan and sc-514 reversed the progenitor state of beta cells. CONCLUSION: The present study found that RAS might induce beta-cell dedifferentiation via angiotensin …
Mechanistically, Angll induced beta-cell dedifferentiation via NF-kappab signaling, while treatment with lrbesartan and sc-514 reversed the …
Tubular epithelial cell-derived extracellular vesicles induce macrophage glycolysis by stabilizing HIF-1α in diabetic kidney disease.
Jia Y, Chen J, Zheng Z, Tao Y, Zhang S, Zou M, Yang Y, Xue M, Hu F, Li Y, Zhang Q, Xue Y, Zheng Z. Jia Y, et al. Mol Med. 2022 Aug 12;28(1):95. doi: 10.1186/s10020-022-00525-1. Mol Med. 2022. PMID: 35962319 Free PMC article.
METHODS: Extracellular vesicles (EVs) from tubular epithelial cells (HK-2) were evaluated using transmission electron microscopy, nanoparticle tracking analysis and western blotting. ...RESULTS: Glycolysis was activated in diabetic renal macrophages after co-culture with H …
METHODS: Extracellular vesicles (EVs) from tubular epithelial cells (HK-2) were evaluated using transmission electron microscopy, nan …
ELAVL1 is transcriptionally activated by FOXC1 and promotes ferroptosis in myocardial ischemia/reperfusion injury by regulating autophagy.
Chen HY, Xiao ZZ, Ling X, Xu RN, Zhu P, Zheng SY. Chen HY, et al. Mol Med. 2021 Feb 10;27(1):14. doi: 10.1186/s10020-021-00271-w. Mol Med. 2021. PMID: 33568052 Free PMC article.
Features of ferroptosis were evidenced by LDH activity, GPx4 activity, cellular iron, ROS, LPO, and GSH levels. The expression levels of autophagy markers (Beclin-1, p62, LC3), ELAVL1 and FOXC1 were measured by qRT-PCR, immunostaining and western blot. ...Si-ELAVL1 repress …
Features of ferroptosis were evidenced by LDH activity, GPx4 activity, cellular iron, ROS, LPO, and GSH levels. The expression levels …
METTL14 promotes glomerular endothelial cell injury and diabetic nephropathy via m6A modification of α-klotho.
Li M, Deng L, Xu G. Li M, et al. Mol Med. 2021 Sep 9;27(1):106. doi: 10.1186/s10020-021-00365-5. Mol Med. 2021. PMID: 34503454 Free PMC article.
METHODS: The expression of METTL14 was detected in DN patients and human renal glomerular endothelial cells (HRGECs). In vitro and in vivo experiments were performed to explore the functions of METTL14 on high glocse-induced HRGECs and renal injury of DN mice. ...CONCLUSIO …
METHODS: The expression of METTL14 was detected in DN patients and human renal glomerular endothelial cells (HRGECs). In vitro and in …
Indole-3-propionic acid alleviates chondrocytes inflammation and osteoarthritis via the AhR/NF-κB axis.
Zhuang H, Ren X, Jiang F, Zhou P. Zhuang H, et al. Mol Med. 2023 Jan 31;29(1):17. doi: 10.1186/s10020-023-00614-9. Mol Med. 2023. PMID: 36721094 Free PMC article.
An OA rat model was established by anterior cruciate ligament transection, and hematoxylin-eosin staining, Safranin-O/Fast Green staining and immunochemistry were applied to estimate OA severity. RESULTS: IPA did not affect cellular viability at concentrations up to 80 M. …
An OA rat model was established by anterior cruciate ligament transection, and hematoxylin-eosin staining, Safranin-O/Fast Green staining an …
The emerging role of pyroptosis-related inflammasome pathway in atherosclerosis.
Xu XD, Chen JX, Zhu L, Xu ST, Jiang J, Ren K. Xu XD, et al. Mol Med. 2022 Dec 21;28(1):160. doi: 10.1186/s10020-022-00594-2. Mol Med. 2022. PMID: 36544112 Free PMC article. Review.
Atherosclerosis (AS), a chronic sterile inflammatory disorder, is one of the leading causes of mortality worldwide. The dysfunction and unnatural death of plaque cells, including vascular endothelial cells (VEC), macrophages, and vascular smooth muscle cells
Atherosclerosis (AS), a chronic sterile inflammatory disorder, is one of the leading causes of mortality worldwide. The dysfunction and unna …
Mechanism and regulation of cellular zinc transport.
Sekler I, Sensi SL, Hershfinkel M, Silverman WF. Sekler I, et al. Mol Med. 2007 Jul-Aug;13(7-8):337-43. doi: 10.2119/2007–00037.Sekler. Mol Med. 2007. PMID: 17622322 Free PMC article. Review.
Thus, the concentration of cellular zinc requires establishment of discrete, active cellular gradients. ...We will also highlight some of the unsolved issues regarding their role in cellular zinc homeostasis....
Thus, the concentration of cellular zinc requires establishment of discrete, active cellular gradients. ...We will also highli …
The role of CD180 in hematological malignancies and inflammatory disorders.
Edwards K, Lydyard PM, Kulikova N, Tsertsvadze T, Volpi EV, Chiorazzi N, Porakishvili N. Edwards K, et al. Mol Med. 2023 Jul 17;29(1):97. doi: 10.1186/s10020-023-00682-x. Mol Med. 2023. PMID: 37460961 Free PMC article. Review.
We first explore the evidence surrounding the role of CD180 in physiology including its expression, function and signaling in antigen presenting cells (APCs) (dendritic cells, monocytes, and B cells). We particularly focus on the role of CD180 as a modulator …
We first explore the evidence surrounding the role of CD180 in physiology including its expression, function and signaling in antigen presen …
Role of exosomes in the development, diagnosis, prognosis and treatment of hepatocellular carcinoma.
Liu M, Lai Z, Yuan X, Jin Q, Shen H, Rao D, Huang D. Liu M, et al. Mol Med. 2023 Oct 17;29(1):136. doi: 10.1186/s10020-023-00731-5. Mol Med. 2023. PMID: 37848835 Free PMC article. Review.
Exosomes are nanoscale vesicles with a lipid bilayer envelope released by various cells under physiological and pathological conditions, which play an important role in the biological information transfer between cells. ...
Exosomes are nanoscale vesicles with a lipid bilayer envelope released by various cells under physiological and pathological conditio …
1,706 results