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Page 1
SGLT-2 inhibitors as cardio-renal protective agents.
Caruso I, Giorgino F. Caruso I, et al. Metabolism. 2022 Feb;127:154937. doi: 10.1016/j.metabol.2021.154937. Epub 2021 Nov 19. Metabolism. 2022. PMID: 34808144 Review.
Despite remarkable advances in diabetes care, patients with type 2 diabetes are still burdened by higher morbidity and mortality than non-diabetic individuals. ...
Despite remarkable advances in diabetes care, patients with type 2 diabetes are still burdened by higher morbidity and mortality than …
Current trends in epidemiology of cardiovascular disease and cardiovascular risk management in type 2 diabetes.
Yun JS, Ko SH. Yun JS, et al. Metabolism. 2021 Oct;123:154838. doi: 10.1016/j.metabol.2021.154838. Epub 2021 Jul 30. Metabolism. 2021. PMID: 34333002 Free article. Review.
With the advances in diabetes care, the trend of incident cardiovascular disease (CVD) in patients with type 2 diabetes mellitus (T2DM) has been decreasing over past decades. ...This review will discuss the current epidemiologic trends of CVD in T2DM and the risk factors l …
With the advances in diabetes care, the trend of incident cardiovascular disease (CVD) in patients with type 2 diabetes mellitus (T2D …
Advances in biological therapies for dyslipidemias and atherosclerosis.
Valanti EK, Dalakoura-Karagkouni K, Siasos G, Kardassis D, Eliopoulos AG, Sanoudou D. Valanti EK, et al. Metabolism. 2021 Mar;116:154461. doi: 10.1016/j.metabol.2020.154461. Epub 2020 Dec 5. Metabolism. 2021. PMID: 33290761 Review.
Atherosclerosis is a multifactorial disease influenced by genetics, lifestyle and environmental factors. Despite therapeutic advances that reduce the risk of cardiovascular events, atherosclerosis-related diseases remain the leading cause of mortality worldwide. ...
Atherosclerosis is a multifactorial disease influenced by genetics, lifestyle and environmental factors. Despite therapeutic advan
Osteogenesis imperfecta - A clinical update.
Tournis S, Dede AD. Tournis S, et al. Metabolism. 2018 Mar;80:27-37. doi: 10.1016/j.metabol.2017.06.001. Epub 2017 Jun 8. Metabolism. 2018. PMID: 28625337 Review.
In the last decade, defects in several other proteins involved in the normal processing of type 1 collagen have been described. Recent advances in genetics have called for reconsideration of the classification of OI, however, most recent classifications align with the clas …
In the last decade, defects in several other proteins involved in the normal processing of type 1 collagen have been described. Recent ad
Novel therapies for osteoporosis.
Makras P, Delaroudis S, Anastasilakis AD. Makras P, et al. Metabolism. 2015 Oct;64(10):1199-214. doi: 10.1016/j.metabol.2015.07.011. Epub 2015 Jul 21. Metabolism. 2015. PMID: 26277199 Review.
Since the identification of osteoporosis as a major health issue in aging populations and the subsequent development of the first treatment modalities for its management, considerable progress has been made in our understanding of the mechanisms controlling bone turnover and dise …
Since the identification of osteoporosis as a major health issue in aging populations and the subsequent development of the first treatment …
Leptin in autoimmune diseases.
Procaccini C, Pucino V, Mantzoros CS, Matarese G. Procaccini C, et al. Metabolism. 2015 Jan;64(1):92-104. doi: 10.1016/j.metabol.2014.10.014. Epub 2014 Oct 23. Metabolism. 2015. PMID: 25467840 Review.
Conversely, elevated circulating leptin levels in obesity appear to contribute to the low-grade inflammatory background which makes obese individuals more susceptible to increased risk of developing cardiovascular diseases, diabetes, or degenerative disease including autoimmunity …
Conversely, elevated circulating leptin levels in obesity appear to contribute to the low-grade inflammatory background which makes obese in …
Current and emerging pharmacological options for the treatment of nonalcoholic steatohepatitis.
Polyzos SA, Kang ES, Boutari C, Rhee EJ, Mantzoros CS. Polyzos SA, et al. Metabolism. 2020 Oct;111S:154203. doi: 10.1016/j.metabol.2020.154203. Epub 2020 Mar 6. Metabolism. 2020. PMID: 32151660 Review.
A significant research effort is also targeting PPARs and selective PPAR modulators, including INT131 and pemafibrate, with the expectation that novel drugs may have beneficial effects similar to those of pioglitazone, but without the associated adverse effects. Whether these and …
A significant research effort is also targeting PPARs and selective PPAR modulators, including INT131 and pemafibrate, with the expectation …
Risk assessment and management of post-transplant diabetes mellitus.
Han E, Kim MS, Kim YS, Kang ES. Han E, et al. Metabolism. 2016 Oct;65(10):1559-69. doi: 10.1016/j.metabol.2016.07.011. Epub 2016 Jul 27. Metabolism. 2016. PMID: 27621191 Review.
The success rate of organ transplantation has been increasing with advances in surgical and pharmacological techniques. However, the number of solid organ transplant recipients who require metabolic disease management is also growing. ...Even though PTDM management is simi …
The success rate of organ transplantation has been increasing with advances in surgical and pharmacological techniques. However, the …
Diabetes in pregnancy 100 years after the discovery of insulin: Hot topics and open questions to be addressed in the coming years.
Retnakaran R. Retnakaran R. Metabolism. 2021 Jun;119:154772. doi: 10.1016/j.metabol.2021.154772. Epub 2021 Apr 8. Metabolism. 2021. PMID: 33838145 Review.
By making it possible for women with diabetes to achieve their family planning goals, the discovery of insulin ushered in the field of diabetes in pregnancy. The ensuing century has witnessed tremendous advances, with clinical focus on preconception planning and maternal g …
By making it possible for women with diabetes to achieve their family planning goals, the discovery of insulin ushered in the field of diabe …