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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 24
2000 44
2001 55
2002 51
2003 53
2004 70
2005 51
2006 71
2007 50
2008 38
2009 69
2010 52
2011 45
2012 33
2013 33
2014 21
2015 24
2016 33
2017 35
2018 29
2019 28
2020 24
2021 32
2022 38
2023 27
2024 5

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999 results

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Page 1
A non-canonical cGAS-STING-PERK pathway facilitates the translational program critical for senescence and organ fibrosis.
Zhang D, Liu Y, Zhu Y, Zhang Q, Guan H, Liu S, Chen S, Mei C, Chen C, Liao Z, Xi Y, Ouyang S, Feng XH, Liang T, Shen L, Xu P. Zhang D, et al. Nat Cell Biol. 2022 May;24(5):766-782. doi: 10.1038/s41556-022-00894-z. Epub 2022 May 2. Nat Cell Biol. 2022. PMID: 35501370
Innate DNA sensing via the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) mechanism surveys microbial invasion and cellular damage and thus participates in various human infectious diseases, autoimmune diseases and cancers. However, how DNA sens …
Innate DNA sensing via the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) mechanism surveys microbial invasion a …
NRF2 mediates melanoma addiction to GCDH by modulating apoptotic signalling.
Verma S, Crawford D, Khateb A, Feng Y, Sergienko E, Pathria G, Ma CT, Olson SH, Scott D, Murad R, Ruppin E, Jackson M, Ronai ZA. Verma S, et al. Nat Cell Biol. 2022 Sep;24(9):1422-1432. doi: 10.1038/s41556-022-00985-x. Epub 2022 Sep 1. Nat Cell Biol. 2022. PMID: 36050469 Free PMC article.
Mechanistically, GCDH knockdown induces NRF2 glutarylation, increasing its stability and DNA binding activity, with a concomitant transcriptional upregulation of ATF4, ATF3, DDIT3 and CHAC1, resulting in cell death. ...
Mechanistically, GCDH knockdown induces NRF2 glutarylation, increasing its stability and DNA binding activity, with a concomitant tra …
Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses.
Chen LL, Morcelle C, Cheng ZL, Chen X, Xu Y, Gao Y, Song J, Li Z, Smith MD, Shi M, Zhu Y, Zhou N, Cheng M, He C, Liu KY, Lu G, Zhang L, Zhang C, Zhang J, Sun Y, Qi T, Lyu Y, Ren ZZ, Tan XM, Yin J, Lan F, Liu Y, Yang H, Qian M, Duan C, Chang X, Zhou Y, Shen L, Baldwin AS, Guan KL, Xiong Y, Ye D. Chen LL, et al. Nat Cell Biol. 2022 Mar;24(3):353-363. doi: 10.1038/s41556-022-00853-8. Epub 2022 Mar 7. Nat Cell Biol. 2022. PMID: 35256775 Free PMC article.
Here we show that ITA is a potent inhibitor of the TET-family DNA dioxygenases. ITA binds to the same site on TET2 as the co-substrate alpha-ketoglutarate, inhibiting TET2 catalytic activity. ...
Here we show that ITA is a potent inhibitor of the TET-family DNA dioxygenases. ITA binds to the same site on TET2 as the co-substrat …
dCas9-based gene editing for cleavage-free genomic knock-in of long sequences.
Wang C, Qu Y, Cheng JKW, Hughes NW, Zhang Q, Wang M, Cong L. Wang C, et al. Nat Cell Biol. 2022 Feb;24(2):268-278. doi: 10.1038/s41556-021-00836-1. Epub 2022 Feb 10. Nat Cell Biol. 2022. PMID: 35145221 Free PMC article.
Gene editing is a powerful tool for genome and cell engineering. Exemplified by CRISPR-Cas, gene editing could cause DNA damage and trigger DNA repair processes that are often error-prone. ...It is effective for inserting kilobase-scale sequences, with an efficiency …
Gene editing is a powerful tool for genome and cell engineering. Exemplified by CRISPR-Cas, gene editing could cause DNA damage and t …
Focus on cell cycle and DNA damage.
[No authors listed] [No authors listed] Nat Cell Biol. 2011 Oct 3;13(10):1153. doi: 10.1038/ncb2357a. Nat Cell Biol. 2011. PMID: 21968986 No abstract available.
Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation.
Zhang H, Freitas D, Kim HS, Fabijanic K, Li Z, Chen H, Mark MT, Molina H, Martin AB, Bojmar L, Fang J, Rampersaud S, Hoshino A, Matei I, Kenific CM, Nakajima M, Mutvei AP, Sansone P, Buehring W, Wang H, Jimenez JP, Cohen-Gould L, Paknejad N, Brendel M, Manova-Todorova K, Magalhães A, Ferreira JA, Osório H, Silva AM, Massey A, Cubillos-Ruiz JR, Galletti G, Giannakakou P, Cuervo AM, Blenis J, Schwartz R, Brady MS, Peinado H, Bromberg J, Matsui H, Reis CA, Lyden D. Zhang H, et al. Nat Cell Biol. 2018 Mar;20(3):332-343. doi: 10.1038/s41556-018-0040-4. Epub 2018 Feb 19. Nat Cell Biol. 2018. PMID: 29459780 Free PMC article.
Exo-S, Exo-L and exomeres each had unique N-glycosylation, protein, lipid, DNA and RNA profiles and biophysical properties. These three nanoparticle subsets demonstrated diverse organ biodistribution patterns, suggesting distinct biological functions. ...
Exo-S, Exo-L and exomeres each had unique N-glycosylation, protein, lipid, DNA and RNA profiles and biophysical properties. These thr …
ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells.
Verma P, Zhou Y, Cao Z, Deraska PV, Deb M, Arai E, Li W, Shao Y, Puentes L, Li Y, Patankar S, Mach RH, Faryabi RB, Shi J, Greenberg RA. Verma P, et al. Nat Cell Biol. 2021 Feb;23(2):160-171. doi: 10.1038/s41556-020-00624-3. Epub 2021 Jan 18. Nat Cell Biol. 2021. PMID: 33462394 Free PMC article.
The response to poly(ADP-ribose) polymerase inhibitors (PARPi) is dictated by homologous recombination (HR) DNA repair and the abundance of lesions that trap PARP enzymes. ...ALC1 deficiency reduced chromatin accessibility concomitant with a decrease in the association of …
The response to poly(ADP-ribose) polymerase inhibitors (PARPi) is dictated by homologous recombination (HR) DNA repair and the abunda …
Metabolic determination of cell fate through selective inheritance of mitochondria.
Döhla J, Kuuluvainen E, Gebert N, Amaral A, Englund JI, Gopalakrishnan S, Konovalova S, Nieminen AI, Salminen ES, Torregrosa Muñumer R, Ahlqvist K, Yang Y, Bui H, Otonkoski T, Käkelä R, Hietakangas V, Tyynismaa H, Ori A, Katajisto P. Döhla J, et al. Nat Cell Biol. 2022 Feb;24(2):148-154. doi: 10.1038/s41556-021-00837-0. Epub 2022 Feb 14. Nat Cell Biol. 2022. PMID: 35165416 Free PMC article.
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.
Rodier F, Coppé JP, Patil CK, Hoeijmakers WA, Muñoz DP, Raza SR, Freund A, Campeau E, Davalos AR, Campisi J. Rodier F, et al. Nat Cell Biol. 2009 Aug;11(8):973-9. doi: 10.1038/ncb1909. Epub 2009 Jul 13. Nat Cell Biol. 2009. PMID: 19597488 Free PMC article.
Cytokine secretion occurred only after establishment of persistent DNA damage signalling, usually associated with senescence, not after transient DNA damage responses (DDRs). ...Thus, in addition to orchestrating cell-cycle checkpoints and DNA repair, a new a …
Cytokine secretion occurred only after establishment of persistent DNA damage signalling, usually associated with senescence, not aft …
PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications.
Shi J, Zhang Y, Tan D, Zhang X, Yan M, Zhang Y, Franklin R, Shahbazi M, Mackinlay K, Liu S, Kuhle B, James ER, Zhang L, Qu Y, Zhai Q, Zhao W, Zhao L, Zhou C, Gu W, Murn J, Guo J, Carrell DT, Wang Y, Chen X, Cairns BR, Yang XL, Schimmel P, Zernicka-Goetz M, Cheloufi S, Zhang Y, Zhou T, Chen Q. Shi J, et al. Nat Cell Biol. 2021 Apr;23(4):424-436. doi: 10.1038/s41556-021-00652-7. Epub 2021 Apr 5. Nat Cell Biol. 2021. PMID: 33820973 Free PMC article.
Although high-throughput RNA sequencing (RNA-seq) has greatly advanced small non-coding RNA (sncRNA) discovery, the currently widely used complementary DNA library construction protocol generates biased sequencing results. ...
Although high-throughput RNA sequencing (RNA-seq) has greatly advanced small non-coding RNA (sncRNA) discovery, the currently widely used co …
999 results