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Year Number of Results
2020 2
2021 4
2022 6
2023 3
2024 1

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12 results

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Page 1
Deletion of Thioredoxin Reductase Disrupts Redox Homeostasis and Impairs beta-Cell Function.
Stancill JS, Hansen PA, Mathison AJ, Schmidt EE, Corbett JA. Stancill JS, et al. Function (Oxf). 2022 Jul 4;3(4):zqac034. doi: 10.1093/function/zqac034. eCollection 2022. Function (Oxf). 2022. PMID: 35873655 Free PMC article.
Reactive oxygen species (ROS) have been implicated as mediators of pancreatic beta-cell damage. While beta-cells are thought to be vulnerable to oxidative damage, we have shown, using inhibitors and acute depletion, that thioredoxin reductase, thioredoxin, and perox …
Reactive oxygen species (ROS) have been implicated as mediators of pancreatic beta-cell damage. While beta-cells are thought t …
Viewing Cortical Collecting Duct Function Through Phenotype-guided Single-Tubule Proteomics.
Himmerkus N, Svendsen SL, Quintanova C, Bleich M, Von Schwerdtner O, Benzing T, Welling PA, Leipziger J, Rinschen MM. Himmerkus N, et al. Function (Oxf). 2020 Jul 2;1(1):zqaa007. doi: 10.1093/function/zqaa007. eCollection 2020. Function (Oxf). 2020. PMID: 35330743 Free PMC article.
CCDs were of 400-600 m of length, showed lumen negative V(te) between -8.5 and -32.5 mV and an equivalent short circuit current I'(sc) between 54 and 192 A/cm(2). On a single-tubule proteome level, intercalated cell (IC) markers strongly correlated with other intercalated …
CCDs were of 400-600 m of length, showed lumen negative V(te) between -8.5 and -32.5 mV and an equivalent short circuit current I'(sc) betwe …
Cytokine and Nitric Oxide-Dependent Gene Regulation in Islet Endocrine and Nonendocrine Cells.
Stancill JS, Kasmani MY, Khatun A, Cui W, Corbett JA. Stancill JS, et al. Function (Oxf). 2021 Dec 1;3(1):zqab063. doi: 10.1093/function/zqab063. eCollection 2022. Function (Oxf). 2021. PMID: 34927076 Free PMC article.
While exposure to inflammatory cytokines is thought to contribute to pancreatic beta-cell damage during diabetes, primarily because cytokine-induced nitric oxide impairs beta-cell function and causes cell death with prolonged exposure, we hypothesize that the …
While exposure to inflammatory cytokines is thought to contribute to pancreatic beta-cell damage during diabetes, primarily because c …
Muscle-Specific Cellular and Molecular Adaptations to Late-Life Voluntary Concurrent Exercise.
Dungan CM, Brightwell CR, Wen Y, Zdunek CJ, Latham CM, Thomas NT, Zagzoog AM, Brightwell BD, VonLehmden GL, Keeble AR, Watowich SJ, Murach KA, Fry CS. Dungan CM, et al. Function (Oxf). 2022 May 23;3(4):zqac027. doi: 10.1093/function/zqac027. eCollection 2022. Function (Oxf). 2022. PMID: 35774589 Free PMC article.
The oxidative soleus of aged mice responds to PoWeR similarly to young mice in every parameter measured in previous work; this includes muscle mass, glycolytic-to-oxidative fiber type transitioning, fiber size, satellite cell frequency, and myonuclear number. The oxidative …
The oxidative soleus of aged mice responds to PoWeR similarly to young mice in every parameter measured in previous work; this includes musc …
Driver Mutations of Pancreatic Cancer Affect Ca2+ Signaling and ATP Production.
Stopa KB, Łoziński F, Kusiak AA, Litewka J, Krzysztofik D, Mosiołek S, Morys J, Ferdek PE, Jakubowska MA. Stopa KB, et al. Function (Oxf). 2023 Jul 4;4(5):zqad035. doi: 10.1093/function/zqad035. eCollection 2023. Function (Oxf). 2023. PMID: 37575483 Free PMC article.
Glandular pancreatic epithelia of the acinar or ductal phenotype may seem terminally differentiated, but they are characterized by remarkable cell plasticity. Stress-induced trans-differentiation of these cells has been implicated in the mechanisms of carcinogenesis …
Glandular pancreatic epithelia of the acinar or ductal phenotype may seem terminally differentiated, but they are characterized by remarkabl …
Integration of High-Throughput Imaging and Multiparametric Metabolic Profiling Reveals a Mitochondrial Mechanism of Tenofovir Toxicity.
Pearson A, Haenni D, Bouitbir J, Hunt M, Payne BAI, Sachdeva A, Hung RKY, Post FA, Connolly J, Nlandu-Khodo S, Jankovic N, Bugarski M, Hall AM. Pearson A, et al. Function (Oxf). 2022 Dec 24;4(1):zqac065. doi: 10.1093/function/zqac065. eCollection 2023. Function (Oxf). 2022. PMID: 36654930 Free PMC article.
Here, we developed an automated, high-throughput imaging pipeline to screen the effects of TDF on solute transport and mitochondrial morphology in human-derived RPTEC/TERT1 cells, and leveraged this to generate realistic models of functional toxicity. ...Thus, we demonstra …
Here, we developed an automated, high-throughput imaging pipeline to screen the effects of TDF on solute transport and mitochondrial morphol …
Traumatic Brain Injury Impairs Systemic Vascular Function Through Disruption of Inward-Rectifier Potassium Channels.
Sackheim AM, Villalba N, Sancho M, Harraz OF, Bonev AD, D'Alessandro A, Nemkov T, Nelson MT, Freeman K. Sackheim AM, et al. Function (Oxf). 2021;2(3):zqab018. doi: 10.1093/function/zqab018. Epub 2021 Apr 6. Function (Oxf). 2021. PMID: 34568829 Free PMC article.
Electrophysiology analysis of freshly-isolated endothelial and smooth muscle cells revealed a significant reduction of Ba(2+)-sensitive Kir2.1 currents after TBI. ...
Electrophysiology analysis of freshly-isolated endothelial and smooth muscle cells revealed a significant reduction of Ba(2+)-sensiti …
Calcium Signaling in the Photodamaged Skin: In Vivo Experiments and Mathematical Modeling.
Donati V, Peres C, Nardin C, Scavizzi F, Raspa M, Ciubotaru CD, Bortolozzi M, Pedersen MG, Mammano F. Donati V, et al. Function (Oxf). 2021 Dec 1;3(1):zqab064. doi: 10.1093/function/zqab064. eCollection 2022. Function (Oxf). 2021. PMID: 35330924 Free PMC article.
Waves expanded radially and rapidly, reaching up to eight orders of bystander cells that remained activated for tens of minutes, without displaying oscillations of the cytosolic free Ca(2+) concentration ([Formula: see text]). By combining in vivo pharmacological dissectio …
Waves expanded radially and rapidly, reaching up to eight orders of bystander cells that remained activated for tens of minutes, with …
Identifying Site-Specific Superoxide and Hydrogen Peroxide Production Rates From the Mitochondrial Electron Transport System Using a Computational Strategy.
Duong QV, Levitsky Y, Dessinger MJ, Strubbe-Rivera JO, Bazil JN. Duong QV, et al. Function (Oxf). 2021 Sep 20;2(6):zqab050. doi: 10.1093/function/zqab050. eCollection 2021. Function (Oxf). 2021. PMID: 35330793 Free PMC article.
Mitochondrial reactive oxygen species (ROS) play important roles in cellular signaling; however, certain pathological conditions such as ischemia/reperfusion (I/R) injury disrupt ROS homeostasis and contribute to cell death. A major impediment to developing therapeutic mea …
Mitochondrial reactive oxygen species (ROS) play important roles in cellular signaling; however, certain pathological conditions such as isc …
12 results