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Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1968 1
1969 2
1970 1
1971 2
1972 2
1973 1
1974 2
1975 4
1976 5
1977 9
1978 5
1979 11
1980 19
1981 16
1982 13
1983 23
1984 37
1985 46
1986 57
1987 57
1988 86
1989 83
1990 123
1991 116
1992 140
1993 154
1994 152
1995 207
1996 208
1997 136
1998 132
1999 149
2000 117
2001 159
2002 126
2003 163
2004 147
2005 157
2006 152
2007 150
2008 183
2009 130
2010 112
2011 110
2012 113
2013 98
2014 143
2015 120
2016 104
2017 93
2018 79
2019 63
2020 50
2021 92
2022 68
2023 49
2024 8

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Search Results

4,435 results

Results by year

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Page 1
The cellular and molecular bases of leptin and ghrelin resistance in obesity.
Cui H, López M, Rahmouni K. Cui H, et al. Nat Rev Endocrinol. 2017 Jun;13(6):338-351. doi: 10.1038/nrendo.2016.222. Epub 2017 Feb 24. Nat Rev Endocrinol. 2017. PMID: 28232667 Free PMC article. Review.
Intensive research over the past several years has yielded tremendous progress in our understanding of the cellular pathways that disrupt the action of leptin and ghrelin. In this Review, we discuss the molecular mechanisms underpinning resistance to leptin and ghre …
Intensive research over the past several years has yielded tremendous progress in our understanding of the cellular pathways that dis …
Current understanding of the molecular and cellular pathology of diabetic retinopathy.
Antonetti DA, Silva PS, Stitt AW. Antonetti DA, et al. Nat Rev Endocrinol. 2021 Apr;17(4):195-206. doi: 10.1038/s41574-020-00451-4. Epub 2021 Jan 19. Nat Rev Endocrinol. 2021. PMID: 33469209 Free PMC article. Review.
The retina is a highly metabolically active tissue that requires a complex interaction of cells, spanning light sensing photoreceptors to neurons that transfer the electrochemical signal to the brain with support by glia and vascular tissue. Neuronal function depends on a …
The retina is a highly metabolically active tissue that requires a complex interaction of cells, spanning light sensing photoreceptor …
Exerkines in health, resilience and disease.
Chow LS, Gerszten RE, Taylor JM, Pedersen BK, van Praag H, Trappe S, Febbraio MA, Galis ZS, Gao Y, Haus JM, Lanza IR, Lavie CJ, Lee CH, Lucia A, Moro C, Pandey A, Robbins JM, Stanford KI, Thackray AE, Villeda S, Watt MJ, Xia A, Zierath JR, Goodpaster BH, Snyder MP. Chow LS, et al. Nat Rev Endocrinol. 2022 May;18(5):273-289. doi: 10.1038/s41574-022-00641-2. Epub 2022 Mar 18. Nat Rev Endocrinol. 2022. PMID: 35304603 Free PMC article. Review.
These beneficial effects enhance overall resilience, healthspan and longevity. The molecular mechanisms that underlie the beneficial effects of exercise, however, remain poorly understood. ...Exerkines are defined as signalling moieties released in response to acute and/or …
These beneficial effects enhance overall resilience, healthspan and longevity. The molecular mechanisms that underlie the beneficial …
Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics.
Morigny P, Boucher J, Arner P, Langin D. Morigny P, et al. Nat Rev Endocrinol. 2021 May;17(5):276-295. doi: 10.1038/s41574-021-00471-8. Epub 2021 Feb 24. Nat Rev Endocrinol. 2021. PMID: 33627836 Free article. Review.
We survey recent advances in humans on the importance of adipocyte hypertrophy and on the in vivo turnover of adipocytes and stored lipids. At the molecular level, the identification of novel regulators and of the interplay between metabolic pathways explains the fine-tuni …
We survey recent advances in humans on the importance of adipocyte hypertrophy and on the in vivo turnover of adipocytes and stored lipids. …
Metformin: update on mechanisms of action and repurposing potential.
Foretz M, Guigas B, Viollet B. Foretz M, et al. Nat Rev Endocrinol. 2023 Aug;19(8):460-476. doi: 10.1038/s41574-023-00833-4. Epub 2023 May 2. Nat Rev Endocrinol. 2023. PMID: 37130947 Free PMC article. Review.
However, increasing evidence points towards other sites of action that might also have an important role, including the gastrointestinal tract, the gut microbial communities and the tissue-resident immune cells. At the molecular level, it seems that the mechanisms o …
However, increasing evidence points towards other sites of action that might also have an important role, including the gastrointestinal tra …
GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease.
Wang D, Day EA, Townsend LK, Djordjevic D, Jørgensen SB, Steinberg GR. Wang D, et al. Nat Rev Endocrinol. 2021 Oct;17(10):592-607. doi: 10.1038/s41574-021-00529-7. Epub 2021 Aug 11. Nat Rev Endocrinol. 2021. PMID: 34381196 Review.
Growth differentiation factor 15 (GDF15) is a member of the TGFbeta superfamily whose expression is increased in response to cellular stress and disease as well as by metformin. Elevations in GDF15 reduce food intake and body mass in animal models through binding to glial …
Growth differentiation factor 15 (GDF15) is a member of the TGFbeta superfamily whose expression is increased in response to cellular
Metabolic pathways in obesity-related breast cancer.
Brown KA. Brown KA. Nat Rev Endocrinol. 2021 Jun;17(6):350-363. doi: 10.1038/s41574-021-00487-0. Epub 2021 Apr 29. Nat Rev Endocrinol. 2021. PMID: 33927368 Free PMC article. Review.
Metabolic pathways of energy production and utilization are dysregulated in tumour cells and this dysregulation is a newly accepted hallmark of cancer. Dysregulated metabolism is also hypothesized to be a feature of non-neoplastic cells in the tumour microenvironmen …
Metabolic pathways of energy production and utilization are dysregulated in tumour cells and this dysregulation is a newly accepted h …
Autophagy in metabolic disease and ageing.
Kitada M, Koya D. Kitada M, et al. Nat Rev Endocrinol. 2021 Nov;17(11):647-661. doi: 10.1038/s41574-021-00551-9. Epub 2021 Sep 10. Nat Rev Endocrinol. 2021. PMID: 34508250 Review.
Autophagy is an evolutionarily conserved, lysosome-dependent catabolic process whereby cytoplasmic components, including damaged organelles, protein aggregates and lipid droplets, are degraded and their components recycled. Autophagy has an essential role in maintaining cellul
Autophagy is an evolutionarily conserved, lysosome-dependent catabolic process whereby cytoplasmic components, including damaged organelles, …
The circadian regulation of food intake.
Challet E. Challet E. Nat Rev Endocrinol. 2019 Jul;15(7):393-405. doi: 10.1038/s41574-019-0210-x. Nat Rev Endocrinol. 2019. PMID: 31073218 Review.
Metabolic hormones, circulating nutrients and visceral neural inputs transmit rhythmic cues that permit (via close and reciprocal molecular interactions that link metabolic processes and circadian clockwork) brain and peripheral organs to be synchronized to feeding time. . …
Metabolic hormones, circulating nutrients and visceral neural inputs transmit rhythmic cues that permit (via close and reciprocal molecul
4,435 results