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Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function.
He D, Xu H, Zhang H, Tang R, Lan Y, Xing R, Li S, Christian E, Hou Y, Lorello P, Caldarone B, Ding J, Nguyen L, Dionne D, Thakore P, Schnell A, Huh JR, Rozenblatt-Rosen O, Regev A, Kuchroo VK. He D, et al. Immunity. 2022 Jan 11;55(1):159-173.e9. doi: 10.1016/j.immuni.2021.12.001. Epub 2022 Jan 3. Immunity. 2022. PMID: 34982959 Free PMC article.
To accommodate the changing needs of the developing brain, microglia must undergo substantial morphological, phenotypic, and functional reprogramming. ...Microglial mitochondria bioenergetics correlated with and were functionally coupled to phagocytic activity in the devel …
To accommodate the changing needs of the developing brain, microglia must undergo substantial morphological, phenotypic, and function …
The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity.
Filipello F, Morini R, Corradini I, Zerbi V, Canzi A, Michalski B, Erreni M, Markicevic M, Starvaggi-Cucuzza C, Otero K, Piccio L, Cignarella F, Perrucci F, Tamborini M, Genua M, Rajendran L, Menna E, Vetrano S, Fahnestock M, Paolicelli RC, Matteoli M. Filipello F, et al. Immunity. 2018 May 15;48(5):979-991.e8. doi: 10.1016/j.immuni.2018.04.016. Epub 2018 May 8. Immunity. 2018. PMID: 29752066 Free article.
Here, we show that TREM2 is essential for microglia-mediated synaptic refinement during the early stages of brain development. The absence of Trem2 resulted in impaired synapse elimination, accompanied by enhanced excitatory neurotransmission and reduced long-range functio …
Here, we show that TREM2 is essential for microglia-mediated synaptic refinement during the early stages of brain development. The ab …
Human microglia maturation is underpinned by specific gene regulatory networks.
Han CZ, Li RZ, Hansen E, Trescott S, Fixsen BR, Nguyen CT, Mora CM, Spann NJ, Bennett HR, Poirion O, Buchanan J, Warden AS, Xia B, Schlachetzki JCM, Pasillas MP, Preissl S, Wang A, O'Connor C, Shriram S, Kim R, Schafer D, Ramirez G, Challacombe J, Anavim SA, Johnson A, Gupta M, Glass IA; Birth Defects Research Laboratory; Levy ML, Haim SB, Gonda DD, Laurent L, Hughes JF, Page DC, Blurton-Jones M, Glass CK, Coufal NG. Han CZ, et al. Immunity. 2023 Sep 12;56(9):2152-2171.e13. doi: 10.1016/j.immuni.2023.07.016. Epub 2023 Aug 14. Immunity. 2023. PMID: 37582369 Free article.
Microglia phenotypes are highly regulated by the brain environment, but the transcriptional networks that specify the maturation of human microglia are poorly understood. ...
Microglia phenotypes are highly regulated by the brain environment, but the transcriptional networks that specify the maturation of h …
Interleukin-10 Prevents Pathological Microglia Hyperactivation following Peripheral Endotoxin Challenge.
Shemer A, Scheyltjens I, Frumer GR, Kim JS, Grozovski J, Ayanaw S, Dassa B, Van Hove H, Chappell-Maor L, Boura-Halfon S, Leshkowitz D, Mueller W, Maggio N, Movahedi K, Jung S. Shemer A, et al. Immunity. 2020 Nov 17;53(5):1033-1049.e7. doi: 10.1016/j.immuni.2020.09.018. Epub 2020 Oct 12. Immunity. 2020. PMID: 33049219 Free article.
Microglia, the resident macrophages of the brain parenchyma, are key players in central nervous system (CNS) development, homeostasis, and disorders. Distinct brain pathologies seem associated with discrete microglia activation modules. ...
Microglia, the resident macrophages of the brain parenchyma, are key players in central nervous system (CNS) development, homeostasis …
Prenatal interleukin 6 elevation increases glutamatergic synapse density and disrupts hippocampal connectivity in offspring.
Mirabella F, Desiato G, Mancinelli S, Fossati G, Rasile M, Morini R, Markicevic M, Grimm C, Amegandjin C, Termanini A, Peano C, Kunderfranco P, di Cristo G, Zerbi V, Menna E, Lodato S, Matteoli M, Pozzi D. Mirabella F, et al. Immunity. 2021 Nov 9;54(11):2611-2631.e8. doi: 10.1016/j.immuni.2021.10.006. Immunity. 2021. PMID: 34758338 Free PMC article.
Maternal interleukin-6 (IL-6) elevation during pregnancy causes abnormal behavior in offspring, but whether these defects result from altered synaptic developmental trajectories remains unclear. ...These findings indicate that IL-6 elevation at early developmental stages i …
Maternal interleukin-6 (IL-6) elevation during pregnancy causes abnormal behavior in offspring, but whether these defects result from …
Co-immunization with hemagglutinin stem immunogens elicits cross-group neutralizing antibodies and broad protection against influenza A viruses.
Moin SM, Boyington JC, Boyoglu-Barnum S, Gillespie RA, Cerutti G, Cheung CS, Cagigi A, Gallagher JR, Brand J, Prabhakaran M, Tsybovsky Y, Stephens T, Fisher BE, Creanga A, Ataca S, Rawi R, Corbett KS, Crank MC, Karlsson Hedestam GB, Gorman J, McDermott AB, Harris AK, Zhou T, Kwong PD, Shapiro L, Mascola JR, Graham BS, Kanekiyo M. Moin SM, et al. Immunity. 2022 Dec 13;55(12):2405-2418.e7. doi: 10.1016/j.immuni.2022.10.015. Epub 2022 Nov 9. Immunity. 2022. PMID: 36356572 Free PMC article.
Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment.
Blank T, Detje CN, Spieß A, Hagemeyer N, Brendecke SM, Wolfart J, Staszewski O, Zöller T, Papageorgiou I, Schneider J, Paricio-Montesinos R, Eisel UL, Manahan-Vaughan D, Jansen S, Lienenklaus S, Lu B, Imai Y, Müller M, Goelz SE, Baker DP, Schwaninger M, Kann O, Heikenwalder M, Kalinke U, Prinz M. Blank T, et al. Immunity. 2016 Apr 19;44(4):901-12. doi: 10.1016/j.immuni.2016.04.005. Immunity. 2016. PMID: 27096319 Free article.
We found that during sickness behavior, single-stranded RNA viruses, double-stranded RNA ligands, and IFNs shared pathways involving engagement of melanoma differentiation-associated protein 5 (MDA5), retinoic acid-inducible gene 1 (RIG-I), and mitochondrial antiviral sign …
We found that during sickness behavior, single-stranded RNA viruses, double-stranded RNA ligands, and IFNs shared pathways involving …
What SARS-CoV-2 does to our brains.
Aschman T, Mothes R, Heppner FL, Radbruch H. Aschman T, et al. Immunity. 2022 Jul 12;55(7):1159-1172. doi: 10.1016/j.immuni.2022.06.013. Epub 2022 Jun 20. Immunity. 2022. PMID: 35777361 Free PMC article. Review.
In theory, the neurological symptoms observed after SARS-CoV-2 infection could be (1) directly caused by the virus infecting brain cells, (2) indirectly by our body's local or systemic immune response toward the virus, (3) by coincidental phenomena, or (4) a combination of …
In theory, the neurological symptoms observed after SARS-CoV-2 infection could be (1) directly caused by the virus infecting brain ce …
Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking.
Liu L, Casner RG, Guo Y, Wang Q, Iketani S, Chan JF, Yu J, Dadonaite B, Nair MS, Mohri H, Reddem ER, Yuan S, Poon VK, Chan CC, Yuen KY, Sheng Z, Huang Y, Bloom JD, Shapiro L, Ho DD. Liu L, et al. Immunity. 2023 Oct 10;56(10):2442-2455.e8. doi: 10.1016/j.immuni.2023.09.003. Epub 2023 Sep 29. Immunity. 2023. PMID: 37776849 Free PMC article.
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