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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 2
1948 2
1949 1
1951 4
1952 3
1953 3
1954 6
1955 6
1956 4
1957 19
1958 26
1959 24
1960 38
1961 59
1962 91
1963 183
1964 235
1965 234
1966 264
1967 318
1968 418
1969 382
1970 469
1971 493
1972 490
1973 570
1974 722
1975 844
1976 957
1977 1119
1978 1142
1979 1305
1980 1629
1981 1924
1982 2318
1983 2478
1984 2985
1985 3762
1986 4358
1987 5132
1988 6101
1989 7583
1990 8849
1991 10359
1992 11627
1993 12939
1994 14707
1995 16119
1996 17254
1997 18071
1998 19287
1999 20690
2000 22644
2001 23615
2002 24666
2003 25384
2004 26451
2005 28739
2006 30289
2007 31667
2008 33260
2009 34117
2010 36215
2011 38827
2012 40705
2013 41882
2014 42807
2015 43470
2016 42356
2017 42545
2018 42494
2019 42929
2020 48268
2021 49186
2022 46258
2023 41131
2024 14045

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994,448 results

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Page 1
Cytokine Storm-Definition, Causes, and Implications.
Jarczak D, Nierhaus A. Jarczak D, et al. Int J Mol Sci. 2022 Oct 3;23(19):11740. doi: 10.3390/ijms231911740. Int J Mol Sci. 2022. PMID: 36233040 Free PMC article. Review.
The human innate and adaptive immune systems consist of effector cells producing cytokines (interleukins, interferons, chemokines, and numerous other mediators). ...Disturbances of this homeostasis can lead to intricate chain reactions resulting in a massive release of …
The human innate and adaptive immune systems consist of effector cells producing cytokines (interleukins, interferons, chemokines, an …
Insights into cytokine-receptor interactions from cytokine engineering.
Spangler JB, Moraga I, Mendoza JL, Garcia KC. Spangler JB, et al. Annu Rev Immunol. 2015;33:139-67. doi: 10.1146/annurev-immunol-032713-120211. Epub 2014 Dec 10. Annu Rev Immunol. 2015. PMID: 25493332 Free PMC article. Review.
Here we review the theory and practice of cytokine engineering and rationalize the mechanisms of several engineered cytokines in the context of structure. We discuss specific examples of how structure-based cytokine engineering has opened new opportunities fo …
Here we review the theory and practice of cytokine engineering and rationalize the mechanisms of several engineered cytokines …
Cytokine Therapy.
Silk AW, Margolin K. Silk AW, et al. Hematol Oncol Clin North Am. 2019 Apr;33(2):261-274. doi: 10.1016/j.hoc.2018.12.004. Epub 2019 Jan 28. Hematol Oncol Clin North Am. 2019. PMID: 30832999 Review.
The processes controlled by cytokines may be co-opted by pathologic states, contributing to processes that threaten host well-being. A nuanced understanding of this immense web of chemical communications will allow us to understand the mechanisms and limitations of current …
The processes controlled by cytokines may be co-opted by pathologic states, contributing to processes that threaten host well-being. …
Cytokine saga in visceral leishmaniasis.
Bhor R, Rafati S, Pai K. Bhor R, et al. Cytokine. 2021 Nov;147:155322. doi: 10.1016/j.cyto.2020.155322. Epub 2020 Oct 28. Cytokine. 2021. PMID: 33127259 Review.
Extensive studies have been documented on the role of cell-mediated immunity (CMI) in protection and counter survival strategies of the parasites leading to downregulation of CMI. The present review attempts to discuss the cytokines in progression or resolution of visceral …
Extensive studies have been documented on the role of cell-mediated immunity (CMI) in protection and counter survival strategies of the para …
Cytokine storm and targeted therapy in hemophagocytic lymphohistiocytosis.
Zhang HQ, Yang SW, Fu YC, Chen MC, Yang CH, Yang MH, Liu XD, He QN, Jiang H, Zhao MY. Zhang HQ, et al. Immunol Res. 2022 Oct;70(5):566-577. doi: 10.1007/s12026-022-09285-w. Epub 2022 Jul 11. Immunol Res. 2022. PMID: 35819695 Review.
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening systemic hyperinflammatory syndrome. The central pathogenesis is an explosive cytokine storm characterized by a significant increase in proinflammatory cytokines, including IL-1beta, IL-6, IL-18, IFN-gam …
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening systemic hyperinflammatory syndrome. The central pathogenesis is an explosive …
Cytokine-based Cancer Immunotherapy: Challenges and Opportunities for IL-10.
Rallis KS, Corrigan AE, Dadah H, George AM, Keshwara SM, Sideris M, Szabados B. Rallis KS, et al. Anticancer Res. 2021 Jul;41(7):3247-3252. doi: 10.21873/anticanres.15110. Epub 2021 Jul 5. Anticancer Res. 2021. PMID: 34230118 Review.
Several issues persist with cytokine-based cancer therapies; these are broadly categorised into a) high toxicity and b) low efficacy. Despite the only moderate benefits with early cytokine-based cancer therapies, advances in molecular engineering, genomics, and mole …
Several issues persist with cytokine-based cancer therapies; these are broadly categorised into a) high toxicity and b) low efficacy. …
Harnessing cytokines and chemokines for cancer therapy.
Propper DJ, Balkwill FR. Propper DJ, et al. Nat Rev Clin Oncol. 2022 Apr;19(4):237-253. doi: 10.1038/s41571-021-00588-9. Epub 2022 Jan 7. Nat Rev Clin Oncol. 2022. PMID: 34997230 Review.
During the past 40 years, cytokines and cytokine receptors have been extensively investigated as either cancer targets or cancer treatments. ...These findings prompted clinical trials of several cytokines or cytokine antagonists, revealing relevant bio …
During the past 40 years, cytokines and cytokine receptors have been extensively investigated as either cancer targets or canc …
Anti-inflammatory cytokines.
Opal SM, DePalo VA. Opal SM, et al. Chest. 2000 Apr;117(4):1162-72. doi: 10.1378/chest.117.4.1162. Chest. 2000. PMID: 10767254 Review.
Cytokines act in concert with specific cytokine inhibitors and soluble cytokine receptors to regulate the human immune response. ...The nature of anti-inflammatory cytokines and soluble cytokine receptors is the focus of this review. ...
Cytokines act in concert with specific cytokine inhibitors and soluble cytokine receptors to regulate the human immune …
Oral cytokine administration.
Rollwagen FM, Baqar S. Rollwagen FM, et al. Immunol Today. 1996 Dec;17(12):548-50. doi: 10.1016/s0167-5699(96)30065-0. Immunol Today. 1996. PMID: 8991284 Review. No abstract available.
Cytokines: From Clinical Significance to Quantification.
Liu C, Chu D, Kalantar-Zadeh K, George J, Young HA, Liu G. Liu C, et al. Adv Sci (Weinh). 2021 Aug;8(15):e2004433. doi: 10.1002/advs.202004433. Epub 2021 Jun 10. Adv Sci (Weinh). 2021. PMID: 34114369 Free PMC article. Review.
Factors affecting cytokines quantification in biological fluids, native levels in different body fluids, sample processing and storage conditions, sensitivity to freeze-thaw, and soluble cytokine receptors are discussed. ...Various quantification platforms for high- …
Factors affecting cytokines quantification in biological fluids, native levels in different body fluids, sample processing and storag …
994,448 results
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