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Long-term efficacy and safety of CT-P6 versus trastuzumab in patients with HER2-positive early breast cancer: final results from a randomized phase III trial

期刊: BREAST CANCER RESEARCH AND TREATMENT, 2021; 188 (3)

Purpose Equivalent efficacy was demonstrated for the biosimilar CT-P6 and trastuzumab following neoadjuvant therapy for patients with human epidermal ......

Serial circulating tumor DNA identification associated with the efficacy and prognosis of neoadjuvant chemotherapy in breast cancer

期刊: BREAST CANCER RESEARCH AND TREATMENT, 2021; 188 (3)

Background Circulating tumor DNA (ctDNA) provides a promising noninvasive alternative to evaluate the efficacy of neoadjuvant chemotherapy (NCT) in br......

Concurrent mutations associated with trastuzumab-resistance revealed by single cell sequencing

期刊: BREAST CANCER RESEARCH AND TREATMENT, 2021; 187 (3)

Purpose HER2-positive breast cancer patients benefit from HER2-targeted therapies, among which the most commonly used is trastuzumab. However, acquire......

KMT2C is a potential biomarker of prognosis and chemotherapy sensitivity in breast cancer

期刊: BREAST CANCER RESEARCH AND TREATMENT, 2021; 189 (2)

Purpose Epigenetic regulation plays critical roles in cancer progression, and high-frequency mutations or expression variations in epigenetic regulato......

Safety and efficacy study of oral metronomic vinorelbine combined with trastuzumab (mNH) in HER2-positive metastatic breast cancer: a phase II trial

期刊: BREAST CANCER RESEARCH AND TREATMENT, 2021; 188 (2)

Purpose We conducted a single-arm prospective phase II trial to evaluate the efficacy and safety of oral metronomic vinorelbine combined with trastuzu......

ZEB1 directly inhibits GPX4 transcription contributing to ROS accumulation in breast cancer cells

期刊: BREAST CANCER RESEARCH AND TREATMENT, 2021; 188 (2)

Purpose Prior studies have noted that zinc finger E-box binding homeobox 1 (ZEB1) is a master transcription regulator, affecting the expression of nea......

NSDHL promotes triple-negative breast cancer metastasis through the TGF beta signaling pathway and cholesterol biosynthesis

期刊: BREAST CANCER RESEARCH AND TREATMENT, 2021; 187 (2)

Purpose Metastasis is the main cause of breast cancer mortality. Recent studies have proved that lipid metabolic reprogramming plays critical roles in......

Neratinib plus capecitabine sustains health-related quality of life in patients with HER2-positive metastatic breast cancer and >= 2 prior HER2-directed regimens

期刊: BREAST CANCER RESEARCH AND TREATMENT, 2021; 188 (2)

Purpose To characterize health-related quality of life (HRQoL) in patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic br......

Medication use and mammographic breast density

期刊: BREAST CANCER RESEARCH AND TREATMENT, 2021; 189 (2)

Purpose A dense breast on mammogram is a strong risk factor for breast cancer. Identifying factors that reduce mammographic breast density could thus ......

Evaluation of endocrine resistance using ESR1 genotyping of circulating tumor cells and plasma DNA

期刊: BREAST CANCER RESEARCH AND TREATMENT, 2021; 188 (1)

Purpose Therapeutic efficacy of hormonal therapies to target estrogen receptor (ER)-positive breast cancer is limited by the acquisition of ligand-ind......

Germline variants in hereditary breast cancer genes are associated with early age at diagnosis and family history in Guatemalan breast cancer

期刊: BREAST CANCER RESEARCH AND TREATMENT, 2021; 189 (2)

Purpose Mutations in hereditary breast cancer genes play an important role in the risk for cancer. Methods Cancer susceptibility genes were sequenced ......

Impact of breast cancer risk factors on clinically relevant prognostic biomarkers for primary breast cancer

期刊: BREAST CANCER RESEARCH AND TREATMENT, 2021; 189 (2)

Purpose In addition to impacting incidence, risk factors for breast cancer may also influence recurrence and survival from the disease. However, it is......

ANETT: PhAse II trial of NEoadjuvant TAK-228 plus Tamoxifen in patients with hormone receptor-positive breast cancer

期刊: BREAST CANCER RESEARCH AND TREATMENT, 2021; 188 (2)

Introduction Neoadjuvant endocrine therapy is often utilized to downstage Estrogen Receptor-positive (ER+) breast cancer prior to surgery. However, th......

Association between BRCA mutational status and survival in patients with breast cancer: a systematic review and meta-analysis

期刊: BREAST CANCER RESEARCH AND TREATMENT, ; ()

Background Studies evaluating role of BRCA mutations on the survival outcomes in breast cancer (BC) patients have given confounding results and hence,......

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