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Downregulation of SOX9 suppresses breast cancer cell proliferation and migration by regulating apoptosis and cell cycle arrest

期刊: ONCOLOGY LETTERS, 2021; 22 (1)

SRY-related high-mobility group box 9 (SOX9) is an important transcriptional factor that regulates diverse genes involved in development and stemness.......

Cytochrome P450: Implications for human breast cancer

期刊: ONCOLOGY LETTERS, 2021; 22 (1)

The treatment options for breast cancer include endocrine therapy, targeted therapy and chemotherapy. However, some patients with triple-negative brea......

Expression and prognostic value of epithelial-to-mesenchymal transition and cancer stem cellmarkersin primary lesions and liver metastases of colorectal cancers

期刊: ONCOLOGY LETTERS, 2021; 22 (1)

Cancer stem cells (CSCs) and epithelial mesenchymal transition (EMT) markers are considered useful indicators associated with metastasis and prognosis......

miR-590-5p targets RMND5A and promotes migration in pancreatic adenocarcinoma cell lines

期刊: ONCOLOGY LETTERS, 2021; 22 (1)

Required for meiotic nuclear division 5 homolog A (RMND5A) functions as an E3 ubiquitin ligase. To date, few studies have investigated the role of RMN......

MicroRNA-383-5p predicts favorable prognosis and inhibits the progression of diffuse large B-cell lymphoma

期刊: ONCOLOGY LETTERS, 2021; 22 (1)

The roles of microRNA (miRNA/miR)-383-5p have been reported in several malignancies, including breast cancer, gastric cancer, ovarian cancer and lung ......

Role of betulinic acid derivative SH-479 in triple negative breast cancer and bone microenvironment

期刊: ONCOLOGY LETTERS, 2021; 22 (2)

Breast cancer has a high prevalence in the general population and is often associated with bone metastasis. Specific therapeutic targets are missing f......

Mitochondrial calcium uniporter promotes cell proliferation and migration in esophageal cancer

期刊: ONCOLOGY LETTERS, 2021; 22 (3)

Increasing evidence has suggested that mitochondrial calcium uniporter (MCU) is involved in various types of cancer. However, its functions remain unc......

Histone deacetylase 1 facilitates aerobic glycolysis and growth of endometrial cancer

期刊: ONCOLOGY LETTERS, 2021; 22 (4)

The deregulation of histone deacetylase 1 (HDAC1) is reportedly involved in the progression of several cancer types. However, its function in endometr......

Cancer-associated fibroblast-derived CCL5 contributes to cisplatin resistance in A549 NSCLC cells partially through upregulation of lncRNA HOTAIR expression

期刊: ONCOLOGY LETTERS, 2021; 22 (4)

Aberrant C-C motif chemokine ligand 5 (CCL5) is associated with disease progression, poor prognosis and chemotherapy resistance in human malignancy. T......

Activation of GPER by E2 promotes proliferation, invasion and migration of breast cancer cells by regulating the miR-124/CD151 pathway

期刊: ONCOLOGY LETTERS, 2021; 21 (6)

Breast cancer is one of the most common malignancies worldwide and is responsible for a high mortality rate. However, the underlying pathological mech......

MicroRNA-133a-3p suppresses malignant behavior of non-small cell lung cancer cells by negatively regulating ERBB2

期刊: ONCOLOGY LETTERS, 2021; 21 (6)

Non-small cell lung cancer (NSCLC) has high morbidity and mortality rates worldwide, and tumor metastasis is generally associated with poor prognosis.......

Dacomitinib improves chemosensitivity of cisplatin-resistant human ovarian cancer cells

期刊: ONCOLOGY LETTERS, 2021; 22 (1)

Drug resistance hinders effectiveness of human ovarian cancer (OC) therapies, such as cisplatin or paclitaxel therapy. Although dacomitinib, a novel a......

Pseudogene legumain promotes thyroid carcinoma progression via the microRNA-495/autophagy pathway

期刊: ONCOLOGY LETTERS, 2021; 22 (2)

The pseudogene legumain (LGMN) has been reported to regulate cancer cell biology. However, the role of LGMN in thyroid carcinoma remains unknown. Here......

Interleukin-22 promotes PD-L1 expression via STAT3 in colon cancer cells

期刊: ONCOLOGY LETTERS, 2021; 22 (4)

Blocking the expression of programmed cell death ligand 1 (PD-L1) is a promising approach for the treatment of colon cancer. The binding of PD-L1 to i......

Predictive effects of preoperative serum CA125 and AFP levels on post-hepatectomy survival in patients with hepatitis B-related hepatocellular carcinoma

期刊: ONCOLOGY LETTERS, 2021; 21 (6)

The association between the serum levels of cancer antigen 125 (CA125; also termed MUC16) and the prognosis of patients with hepatocellular carcinoma ......

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