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The primordial differentiation of tumor-specific memory CD8+T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes

期刊: CELL, 2022; 185 (22)

Blocking PD-1/PD-L1 signaling transforms cancer therapy and is assumed to unleash exhausted tumor -reac-tive CD8+ T cells in the tumor microenvironmen......

JIF:28.45

The deep population history of northern East Asia from the Late Pleistocene to the Holocene

期刊: CELL, 2021; 184 (12)

Northern East Asia was inhabited by modern humans as early as 40 thousand years ago (ka), as demonstrated by the Tianyuan individual. Using genome-wid......

Pan-genome analysis of 33 genetically diverse rice accessions reveals hidden genomic variations

期刊: CELL, 2021; 184 (13)

Structural variations (SVs) and gene copy number variations (gCNVs) have contributed to crop evolution, domestication, and improvement. Here, we assem......

Binding and molecular basis of the bat coronavirus RaTG13 virus to ACE2 in humans and other species

期刊: CELL, 2021; 184 (13)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been spreading worldwide, causing a global pandemic. Bat-origin RaTG13 is currently t......

Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis

期刊: CELL, 2021; 184 (8)

Cutaneous mast cells mediate numerous skin inflammatory processes and have anatomical and functional associations with sensory afferent neurons. We re......

Structural basis of assembly and torque transmission of the bacterial flagellar motor

期刊: CELL, 2021; 184 (10)

The bacterial flagellar motor is a supramolecular protein machine that drives rotation of the flagellum for motility, which is essential for bacterial......

SARS-CoV-2 501Y.V2 variants lack higher infectivity but do have immune escape

期刊: CELL, 2021; 184 (9)

The 501Y.V2 variants of SARS-CoV-2 containing multiple mutations in spike are now dominant in South Africa and are rapidly spreading to other countrie......

Mouse totipotent stem cells captured and maintained through spliceosomal repression

期刊: CELL, 2021; 184 (11)

Since establishment of the first embryonic stem cells (ESCs), in vitro culture of totipotent cells functionally and molecularly comparable with in viv......

Iterative tomography with digital adaptive optics permits hour-long intravital observation of 3D subcellular dynamics at millisecond scale

期刊: CELL, 2021; 184 (12)

Long-term subcellular intravital imaging in mammals is vital to study diverse intercellular behaviors and organelle functions during native physiologi......

The origins of viral infection sleuth

期刊: CELL, 2021; 184 (8)

The events of the past year have underscored the serious and rapid threat that emerging viruses pose to global health. However, much of the rapid prog......

COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas

期刊: CELL, 2021; 184 (7)

A dysfunctional immune response in coronavirus disease 2019 (COVID-19) patients is a recurrent theme impacting symptoms and mortality, yet a detailed ......

Genome design of hybrid potato

期刊: CELL, 2021; 184 (15)

Reinventing potato from a clonally propagated tetraploid into a seed-propagated diploid, hybrid potato, is an important innovation in agriculture. Due......

Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system

期刊: CELL, 2021; 184 (8)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause acute respiratory disease and multiorgan failure. Finding human host factors th......

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