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A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement

期刊: JOURNAL OF HEPATOLOGY, 2020; 73 (1)

The exclusion of other chronic liver diseases including "excess" alcohol intake has until now been necessary to establish a diagnosis of metabolic dys......

Stereotactic body radiation therapy vs. radiofrequency ablation in Asian patients with hepatocellular carcinoma

期刊: JOURNAL OF HEPATOLOGY, 2020; 73 (1)

Background & Aims: Few studies have been conducted to compare the efficacies of stereotactic body radiation therapy (SBRT) and radiofrequency abla......

Toll-like receptor 4 is a therapeutic target for prevention and treatment of liver failure

期刊: JOURNAL OF HEPATOLOGY, 2020; 73 (1)

Background & Aims: Toll-like receptor 4 (TLR4) plays an essential role in mediating organ injury in acute liver failure (ALF) and acute-on-chronic......

Genotype correlates with the natural history of severe bile salt export pump deficiency

期刊: JOURNAL OF HEPATOLOGY, 2020; 73 (1)

Background & Aims: Mutations in ABCB11 can cause deficiency of the bile salt export pump (BSEP), leading to cholestasis and end-stage liver diseas......

Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: Results from randomized phase III STELLAR trials

期刊: JOURNAL OF HEPATOLOGY, 2020; 73 (1)

Background & Aims: Apoptosis signal-regulating kinase 1 (ASK1) plays a key role in hepatocyte injury, inflammation, and fibrosis in non-alcoholic ......

Newly identified peptide hormone inhibits intestinal fat absorption and improves NAFLD through its receptor GPRC6A

期刊: JOURNAL OF HEPATOLOGY, 2020; 73 (2)

Background & Aims: Circulating peptides and G protein-coupled receptors (GPCRs) have gained much attention because of their biofunctions in metabo......

RNA G-quadruplex regulates microRNA-26a biogenesis and function

期刊: JOURNAL OF HEPATOLOGY, 2020; 73 (2)

Background & Aims: RNA G-quadruplexes (RG4s) appear to be important in post-transcriptional gene regulation, but their pathophysiological function......

Inhibition of PU.1 ameliorates metabolic dysfunction and non-alcoholic steatohepatitis

期刊: JOURNAL OF HEPATOLOGY, 2020; 73 (2)

Background & Aims: Obesity is a well-established risk factor for type 2 diabetes (T2D) and non-alcoholic steatohepatitis (NASH), but the underlyin......

Causal relationships between NAFLD, T2D and obesity have implications for disease subphenotyping

期刊: JOURNAL OF HEPATOLOGY, 2020; 73 (2)

Background & Aims: Non-alcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D) and obesity are epidemiologically correlated with each other b......

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