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Mouse Liver Sinusoidal Endothelium Eliminates HIV-Like Particles from Blood at a Rate of 100 Million per Minute by a Second-Order Kinetic Process

期刊: Frontiers in Immunology, 2017; 8 ( )

We crafted human immunodeficiency virus (HIV)-like particles of diameter about 140 nm, which expressed two major HIV-1 proteins, namely, env and gag g......

JIF:5.51

Applications of Genetically Modified Immunobiotics with High Immunoregulatory Capacity for Treatment of Inflammatory Bowel Diseases

期刊: Frontiers in Immunology, 2017; 8 ( )

Inflammatory bowel diseases (IBDs), including ulcerative colitis and Crohn's disease, are chronic inflammatory diseases characterized by dysregulated ......

JIF:5.51

Canonical and Non-Canonical Aspects of JAK-STAT Signaling: Lessons from interferons for Cytokine Responses

期刊: Frontiers in Immunology, 2017; 8 ( )

Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signal transduction mediates cytokine responses. Canonical signaling is bas......

JIF:5.51

Fc Engineering for Developing Therapeutic Bispecific Antibodies and Novel Scaffolds

期刊: Frontiers in Immunology, 2017; 8 ( )

Therapeutic monoclonal antibodies have become molecules of choice to treat autoimmune disorders, inflammatory diseases, and cancer. Moreover, bispecif......

JIF:5.51

Antigen Exposure History Defines CD8 T Cell Dynamics and Protection during Localized Pulmonary Infections

期刊: Frontiers in Immunology, 2017; 8 ( )

Unlike systemic infections, little is known about the role of repeated localized infections on (re) shaping pathogen-specific memory CD8 T cell respon......

JIF:5.51

Defective IL-23/IL-17 Axis Protects p47phox-/-Mice from Colon Cancer

期刊: Frontiers in Immunology, 2017; 8 ( )

In the colon, a sophisticated balance between immune reaction and tolerance is absolutely required. Dysfunction may lead to pathologic phenotypes rang......

JIF:5.51

Capability of Neutrophils to Form NETs Is Not Directly Influenced by a CMA-Targeting Peptide

期刊: Frontiers in Immunology, 2017; 8 ( )

During inflammatory reaction, neutrophils exhibit numerous cellular and immunological functions, notably the formation of neutrophil extracellular tra......

JIF:5.51

The NLRP3 and Pyrin Inflammasomes: Implications in the Pathophysiology of Autoinflammatory Diseases

期刊: Frontiers in Immunology, 2017; 8 ( )

Inflammasomes are multiprotein complexes that critically control different aspects of innate and adaptive immunity. Among them we could highlight the ......

JIF:5.51

Structure and Dynamics of Antigenic Peptides in Complex with TAP

期刊: Frontiers in Immunology, 2017; 8 ( )

The transporter associated with antigen processing (TAP) selectively translocates antigenic peptides into the endoplasmic reticulum. Loading onto majo......

JIF:5.51

Nasal Polyp-Derived Mesenchymal Stromal Cells Exhibit Lack of Immune-Associated Molecules and High Levels of Stem/Progenitor Cells Markers

期刊: Frontiers in Immunology, 2017; 8 ( )

Mesenchymal stromal cells (MSCs) are considered adult progenitor stem cells and have been studied in a multitude of tissues. In this context, the micr......

JIF:5.51

Curcumin Attenuates Titanium Particle-Induced Inflammation by Regulating Macrophage Polarization In Vitro and In Vivo

期刊: Frontiers in Immunology, 2017; 8 ( )

Periprosthetic inflammatory osteolysis and subsequent aseptic loosening are commonly observed in total joint arthroplasty. Other than revision surgery......

JIF:5.51

Treatment of Infantile Inflammatory Bowel Disease and Autoimmunity by Allogeneic Stem Cell Transplantation in LPS-Responsive Beige-Like Anchor Deficiency

期刊: Frontiers in Immunology, 2017; 8 ( )

Inflammatory bowel disease (IBD) in young children can be a clinical manifestation of various primary immunodeficiency syndromes. Poor clinical outcom......

JIF:5.51

Sublingual Priming with a HIV gp41-Based Subunit Vaccine Elicits Mucosal Antibodies and Persistent B Memory Responses in Non-Human Primates

期刊: Frontiers in Immunology, 2017; 8 ( )

Persistent B cell responses in mucosal tissues are crucial to control infection against sexually transmitted pathogens like human immunodeficiency vir......

JIF:5.51

Differential Ability of Bovine Antimicrobial Cathelicidins to Mediate Nucleic Acid Sensing by Epithelial Cells

期刊: Frontiers in Immunology, 2017; 8 ( )

Cathelicidins encompass a family of cationic peptides characterized by antimicrobial activity and other functions, such as the ability to enhance the ......

JIF:5.51

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