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Role of serotonin in regulation of pancreatic and mesenteric arterial function in diabetic mice

期刊: EUROPEAN JOURNAL OF PHARMACOLOGY, 2021; 901 ()

The aim of this study was to investigate the reaction of pancreatic and mesenteric artery to 5-hydroxytryptamine (5-HT, serotonin) and the mechanism o......

Aspirin ameliorates pulmonary vascular remodeling in pulmonary hypertension by dampening endothelial-to-mesenchymal transition

期刊: EUROPEAN JOURNAL OF PHARMACOLOGY, 2021; 908 ()

Pulmonary vascular remodeling (PVR) is the pathological basis of pulmonary hypertension (PH). Incomplete understanding of PVR etiology has hindered dr......

Sinomenine alleviates dorsal root ganglia inflammation to inhibit neuropathic pain via the p38 MAPK/CREB signalling pathway

期刊: EUROPEAN JOURNAL OF PHARMACOLOGY, 2021; 897 ()

The objective of study was to investigate the inhibitory effect of sinomenine on neuropathic pain on dorsal root ganglia (DRG). The DRG cell line and ......

Melanocortin receptor-4 mediates the anorectic effect induced by the nucleus tractus solitarius injection of glucagon-like Peptide-2 in fasted rats

期刊: EUROPEAN JOURNAL OF PHARMACOLOGY, 2021; 901 ()

Glucagon-like peptide-2 (GLP-2) is secreted from enteroendocrine L-type cells of the gut and also released from preproglucagonergic (PPG) neurons in t......

L-theanine inhibits foam cell formation via promoting the scavenger receptor A degradation

期刊: EUROPEAN JOURNAL OF PHARMACOLOGY, 2021; 904 ()

Atherosclerosis is one of the most common cardiovascular diseases with highly mortality worldwide. The formation of foam cell plays an important role ......

A brief review of urate transporter 1 (URAT1) inhibitors for the treatment of hyperuricemia and gout: Current therapeutic options and potential applications

期刊: EUROPEAN JOURNAL OF PHARMACOLOGY, 2021; 907 ()

Hyperuricemia is a common metabolic condition, cause by increased levels of serum urate (SUA). Reduced excretion of uric acid is reported as the key f......

Ceritinib increases sensitivity of AKT inhibitors to gastric cancer

期刊: EUROPEAN JOURNAL OF PHARMACOLOGY, 2021; 896 ()

Gastric cancer (GC), known for high morbidity and mortality, is poorly prognosed with traditional chemotherapy and biological agents. Current studies ......

Discovery of a highly potent kinase inhibitor capable of overcoming multiple imatinib-resistant ABL mutants for chronic myeloid leukemia (CML)

期刊: EUROPEAN JOURNAL OF PHARMACOLOGY, 2021; 897 ()

As the critical driving force for chronic myeloid leukemia (CML), BCR gene fused ABL kinase has been extensively explored as a validated target of dru......

Roles and mechanisms of adipokines in drug resistance of tumor cells

期刊: EUROPEAN JOURNAL OF PHARMACOLOGY, 2021; 899 ()

The drug resistance of cancer cells has become one of the biggest obstacles of effective anticancer treatments. Adipocytes produce plenty of cytokines......

RS4651 suppresses lung fibroblast activation via the TGF-beta 1/SMAD signalling pathway

期刊: EUROPEAN JOURNAL OF PHARMACOLOGY, 2021; 903 ()

Background: Idiopathic pulmonary fibrosis (IPF) is a progressive disease resulting in respiratory failure with no efficient treatment options. We inve......

Diosgenin exerts anti-tumor effects through inactivation of cAMP/PKA/ CREB signaling pathway in colorectal cancer

期刊: EUROPEAN JOURNAL OF PHARMACOLOGY, 2021; 908 ()

Colorectal cancer (CRC) is the most fatal gastrointestinal tumor and it is urge to explore powerful drugs for the treatment. Diosgenin (DSG) as a new ......

Dioscin alleviates lung ischemia/reperfusion injury by regulating FXR-mediated oxidative stress, apoptosis, and inflammation

期刊: EUROPEAN JOURNAL OF PHARMACOLOGY, 2021; 908 ()

Dioscin showed various pharmacological effects in our previous studies; however, the effects and mechanisms against lung ischemia/reperfusion injury (......

Repositioning of histamine H-1 receptor antagonist: Doxepin inhibits viropexis of SARS-CoV-2 Spike pseudovirus by blocking ACE2

期刊: EUROPEAN JOURNAL OF PHARMACOLOGY, 2021; 896 ()

The spread of the corona virus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been intens......

Tubeimoside I protects against sepsis-induced cardiac dysfunction via SIRT3

期刊: EUROPEAN JOURNAL OF PHARMACOLOGY, 2021; 905 ()

Sepsis-induced cardiac dysfunction (SICD) is one of the key complications in sepsis and it is associated with adverse outcomes and increased mortality......

Modulation of the tumor microenvironment (TME) by melatonin

期刊: EUROPEAN JOURNAL OF PHARMACOLOGY, 2021; 907 ()

The tumor microenvironment (TME) includes a number of non-cancerous cells that affect cancer cell survival. Although CD8+ T lymphocytes and natural ki......

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