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Tpt1 the balance toward immunosuppression upon cell death

期刊: NATURE IMMUNOLOGY, 2021; 22 (8)

By engaging Toll-like receptor 2, translationally controlled tumor protein (TCTP) released from necrotic tumor cells can switch on an immunosuppressiv......

Metabolic reprogramming of terminally exhausted CD8(+) T cells by IL-10 enhances anti-tumor immunity

期刊: NATURE IMMUNOLOGY, 2021; 22 (6)

T cell exhaustion presents one of the major hurdles to cancer immunotherapy. Among exhausted CD8(+) tumor-infiltrating lymphocytes, the terminally exh......

Targeting regulator of G protein signaling 1 in tumor-specific T cells enhances their trafficking to breast cancer

期刊: NATURE IMMUNOLOGY, 2021; 22 (7)

Effective control of tumors requires the presence of inflammatory helper and cytotoxic T cells. Song and colleagues demonstrate that the protein RGS1 ......

Dynamic regulation of B cell complement signaling is integral to germinal center responses

期刊: NATURE IMMUNOLOGY, 2021; 22 (6)

Heeger and colleagues report that activated B cells dynamically regulate the expression of complement regulatory proteins via the transcription factor......

Protective Zika vaccines engineered to eliminate enhancement of dengue infection via immunodominance switch

期刊: NATURE IMMUNOLOGY, 2021; 22 (8)

Antibody-dependent enhancement (ADE) is an important safety concern for vaccine development against dengue virus (DENV) and its antigenically related ......

Insulin signaling establishes a developmental trajectory of adipose regulatory T cells

期刊: NATURE IMMUNOLOGY, 2021; 22 (9)

Adipose tissue-resident regulatory T (T-reg) cells are important for maintaining normal metabolic function and adiposity. Li and colleagues demonstrat......

Selenium-GPX4 axis protects follicular helper T cells from ferroptosis

期刊: NATURE IMMUNOLOGY, 2021; 22 (9)

Follicular helper T (T-FH) cells are a specialized subset of CD4(+) T cells that essentially support germinal center responses where high-affinity and......

Glutathione peroxidase 4-regulated neutrophil ferroptosis induces systemic autoimmunity

期刊: NATURE IMMUNOLOGY, 2021; 22 (9)

Zhang and colleagues identify a role for cell death by glutathione peroxidase 4 (GPX4)-regulated ferroptosis in neutrophils from patients with systemi......

Hallmarks of T cell aging

期刊: NATURE IMMUNOLOGY, 2021; 22 (6)

In this Review, Mittelbrunn and Kroemer propose that ten molecular hallmarks represent the common denominators of T cell aging. The aged adaptive immu......

Coupled analysis of transcriptome and BCR mutations reveals role of OXPHOS in affinity maturation

期刊: NATURE IMMUNOLOGY, 2021; 22 (7)

Antigen-activated B cells diversify variable regions of B cell antigen receptors by somatic hypermutation in germinal centers (GCs). The positive sele......

Essential role of a ThPOK autoregulatory loop in the maintenance of mature CD4(+) T cell identity and function

期刊: NATURE IMMUNOLOGY, 2021; 22 (8)

The transcription factor ThPOK (encoded by the Zbtb7b gene) controls homeostasis and differentiation of mature helper T cells, while opposing their di......

Multi-omics analyses reveal that HIV-1 alters CD4(+) T cell immunometabolism to fuel virus replication

期刊: NATURE IMMUNOLOGY, ; ()

Individuals infected with human immunodeficiency virus type-1 (HIV-1) show metabolic alterations of CD4(+) T cells through unclear mechanisms with und......

Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion

期刊: NATURE IMMUNOLOGY, 2021; 22 (2)

Delgoffe and colleagues show that continuous TCR signaling and hypoxia increase Blimp-1, which suppresses PGC-1 alpha-dependent mitochondrial reprogra......

IL-2 regulates tumor-reactive CD8(+) T cell exhaustion by activating the aryl hydrocarbon receptor

期刊: NATURE IMMUNOLOGY, 2021; 22 (3)

CD8(+) T cell exhaustion dampens antitumor immunity. Although several transcription factors have been identified that regulate T cell exhaustion, the ......

Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation

期刊: NATURE IMMUNOLOGY, 2021; 22 (2)

During the germinal center (GC) reaction, B cells undergo extensive redistribution of cohesin complex and three-dimensional reorganization of their ge......

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