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Progressive erythrocytosis under lenvatinib treatment in patients with advanced hepatocellular carcinoma

期刊: CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2023; 91 (4)

PurposeThis manuscript reports on the occurrence of early and frequent erythrocytosis in advanced hepatocellular carcinoma (HCC) patients treated with......

Advanced statistics identification of participant and treatment predictors associated with severe adverse effects induced by fluoropyrimidine-based chemotherapy

期刊: CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2023; 91 (6)

PurposeAdverse effects following fluoropyrimidine-based chemotherapy regimens are common. However, there are no current accepted diagnostic markers fo......

A biscarbene gold(I)-NHC-complex overcomes cisplatin-resistance in A2780 and W1 ovarian cancer cells highlighting pERK as regulator of apoptosis

期刊: CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2023; 92 (1)

PurposeCisplatin resistance is the major obstacle in the clinical treatment of ovarian cancer patients. Molecular mechanisms of cisplatin resistance a......

Life-threatening toxicities upon Pembrolizumab intake: could pharmacokinetics be the bad guy?

期刊: CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2023; ()

PurposeWe report the case of an adult patient diagnosed with Hodgkin's lymphoma who was scheduled for Pembrolizumab after failure of standard therapy.......

Bioequivalence, food effect and comparative pharmacokinetics of SUVN-1105, a novel granule formulation of abiraterone acetate, to Zytiga in healthy male subjects

期刊: CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2023; ()

PurposeSUVN-1105 is a novel formulation of abiraterone acetate which was developed to demonstrate improved bioavailability, compared to Zytiga and Yon......

Cabozantinib-induced serum creatine kinase elevation and rhabdomyolysis: a retrospective case series

期刊: CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2023; 92 (3)

PurposeRhabdomyolysis, which is primarily characterized by serum creatine kinase (CK) elevation, is a potentially fatal disease, and it can occur in a......

Polatuzumab vedotin pharmacokinetics in a hemodialysis patient with diffuse large B-cell lymphoma

期刊: CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2023; ()

PurposeChemotherapy for the hemodialysis (HD) patient is a challenging situation because it requires special considerations including dose modificatio......

Real-world data on the management of pazopanib-induced liver toxicity in routine care of renal cell cancer and soft tissue sarcoma patients

期刊: CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2023; ()

PurposePazopanib is known to cause liver toxicity. A relationship between pazopanib exposure and alanine transaminase elevations has been described in......

Precision fluoropyrimidines dosing in a compound heterozygous variant carrier of the DPYD gene: a case report

期刊: CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2023; 91 (5)

BackgroundFluoropyrimidines (FPs) form still nowadays the backbone of chemotherapic schemes in colorectal cancer (CRC). Inter-patient variability of t......

A PK-PD model linking biomarker dynamics to progression-free survival in patients treated with everolimus and sorafenib combination therapy, EVESOR phase I trial

期刊: CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2023; 91 (5)

Purpose The objective was to develop a pharmacokinetic-pharmacodynamic (PK-PD) model linking everolimus and sorafenib exposure with biomarker dynamics......

Effects of splicing-regulatory polymorphisms in ABCC2, ABCG2, and ABCB1 on methotrexate exposure in Chinese children with acute lymphoblastic leukemia

期刊: CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2023; 91 (1)

PurposeAdenosine triphosphate (ATP)-binding cassette (ABC) transporters play an important role in the response to methotrexate (MTX). In this study, w......

A bioequivalence study of trifluridine/tipiracil tablets in Chinese metastatic colorectal cancer patients under fed conditions

期刊: CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2023; 91 (2)

Purpose Colorectal cancer (CRC) is the second most common cause of cancer death worldwide. Trifluridine (FTD) remained at higher concentrations longer......

A prospective feasibility study of uracil-tegafur and leucovorin as adjuvant chemotherapy for patients aged ≥ 80 years after curative resection of colorectal cancer, the HiSCO-03 study

期刊: CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2023; 91 (4)

PurposeThere is no consensus on the safety and effectiveness of adjuvant chemotherapy for patients with stage III colorectal cancer (CRC) aged >= 8......

The role of alternative splicing in lung cancer

期刊: CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2023; 92 (2)

Aberrant alternative splicing (AS) events are frequently observed in lung cancer, which can be attributed to aberrant gene AS, alterations in splicing......

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