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Identification of unanimous immune subtypes for different hormone receptor phenotypes of human breast cancer with potential prognostic significance

期刊: INTERNATIONAL IMMUNOPHARMACOLOGY, 2021; 94 ()

The immunogenicity of the breast tumor microenvironment is clinically heterogeneous. The insight into the role of tumor-infiltrating lymphocytes (TILs......

Exploring a novel triptolide derivative possess anti-colitis effect via regulating T cell differentiation

期刊: INTERNATIONAL IMMUNOPHARMACOLOGY, 2021; 94 ()

Inflammatory bowel disease (IBD) is generally characterized by chronic inflammatory disorders of the gastrointestinal tract that are known as ulcerati......

Landscape of SARS-CoV-2 spike protein-interacting cells in human tissues

期刊: INTERNATIONAL IMMUNOPHARMACOLOGY, 2021; 95 ()

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic. However, the ......

Alpinetin protects against hepatic ischemia/reperfusion injury in mice by inhibiting the NF-kappa B/MAPK signaling pathways

期刊: INTERNATIONAL IMMUNOPHARMACOLOGY, 2021; 95 ()

Liver damage induced by ischemia/reperfusion (I/R) remains a primary issue in liver transplantation and resection. Alpinetin, a novel plant flavonoid ......

Safinamide prevents lipopolysaccharide (LPS)-induced inflammation in macrophages by suppressing TLR4/NF-kappa B signaling

期刊: INTERNATIONAL IMMUNOPHARMACOLOGY, 2021; 96 ()

Inflammation is a basal host defense response that eliminates the causes and consequences of infection and tissue injury. Macrophages are the primary ......

Evaluating the efficacy and safety of immune checkpoint inhibitors by detecting the exposure-response: An inductive review

期刊: INTERNATIONAL IMMUNOPHARMACOLOGY, 2021; 97 ()

Immune checkpoint inhibitors (ICIs) have been demonstrated an effective treatment in multiple tumor type, which restore the immune response to against......

Immunological and inflammatory profiles during acute and convalescent phases of severe/ critically ill COVID-19 patients

期刊: INTERNATIONAL IMMUNOPHARMACOLOGY, 2021; 97 ()

Background: The 2019 Coronavirus (COVID-19) pandemic poses a huge threat internationally; however, the role of the host immune system in the pathogene......

The differentiation of new human CD303(+) Plasmacytoid dendritic cell subpopulations expressing CD205 and/or CD103 regulated by Non-Small-Cell lung cancer cells

期刊: INTERNATIONAL IMMUNOPHARMACOLOGY, 2021; 99 ()

CD303(+) plasmacytoid dendritic cells (pDCs) play an important role in the induction of immune tolerance and antitumor immunity. Here, we focused on t......

Selective Inhibition of NLRP3 Inflammasome Reverses Pressure Overload-Induced Pathological Cardiac Remodeling by Attenuating Hypertrophy, Fibrosis, and Inflammation

期刊: INTERNATIONAL IMMUNOPHARMACOLOGY, 2021; 99 ()

Activation of the NLRP3 inflammasome promotes pathological cardiac remodeling induced by pressure overload. However, the therapeutic effects of NLRP3 ......

Butyrate functions in concert with myeloid-derived suppressor cells recruited by CCR9 to alleviate DSS-induced murine colitis

期刊: INTERNATIONAL IMMUNOPHARMACOLOGY, 2021; 99 ()

Ulcerative colitis (UC) is a precancerous disease caused mainly by a combination of genetic susceptibility, environmental factors and microbiota dysbi......

IDO1 as a new immune biomarker for diabetic nephropathy and its correlation with immune cell infiltration

期刊: INTERNATIONAL IMMUNOPHARMACOLOGY, 2021; 94 ()

Introduction: Indoleamine 2,3-dioxygenase 1(IDO1) has complicated roles in immune-inflammatory response regulation, but its correlation with immune ce......

The role of interleukin-10 family members in cardiovascular diseases

期刊: INTERNATIONAL IMMUNOPHARMACOLOGY, 2021; 94 ()

Interleukin (IL)-10 cytokine family members, including IL-10, IL-19, IL-20, IL-22, IL-24, IL-26 and the distantly related IL-28A, IL-28B, and IL-29, p......

Clinical and molecular immune characterization of ERBB2 in glioma

期刊: INTERNATIONAL IMMUNOPHARMACOLOGY, 2021; 94 ()

ERBB2 is a well-studied oncogene that promotes progression of multiple cancers, especially in breast cancer. However, the expression status of ERBB2, ......

Hydrogen gas alleviates sepsis-induced neuroinflammation and cognitive impairment through regulation of DNMT1 and DNMT3a-mediated BDNF promoter IV methylation in mice

期刊: INTERNATIONAL IMMUNOPHARMACOLOGY, 2021; 95 ()

Sepsis-associated encephalopathy (SAE) can cause acute and long-term cognitive impairment and increase the mortality rate in sepsis patients, and we p......

Decreased expression of TIPE2 in the eye under high-glucose conditions tested in vivo and in vitro

期刊: INTERNATIONAL IMMUNOPHARMACOLOGY, 2021; 95 ()

Aims: Inflammation is important in the development of angiogenesis diabetic retinopathy (DR). Antiinflammation is promising strategy in early DR manag......

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