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T cell counts and IL-6 concentration in blood of North African COVID-19 patients are two independent prognostic factors for severe disease and death

期刊: JOURNAL OF LEUKOCYTE BIOLOGY, 2022; 111 (1)

The immune system plays a crucial role in the response against severe acute respiratory syndrome coronavirus 2 with significant differences among pati......

JIF:4.277

Pulmonary and blood dendritic cells from sarcoidosis patients more potently induce IFN gamma-producing Th1 cells compared with monocytes

期刊: JOURNAL OF LEUKOCYTE BIOLOGY, 2022; 111 (4)

Sarcoidosis is a systemic inflammatory disease mainly affecting the lungs. The hallmark of sarcoidosis are granulomas that are surrounded by activated......

JIF:4.277

ADAM17/MMP inhibition prevents neutrophilia and lung injury in a mouse model of COVID-19

期刊: JOURNAL OF LEUKOCYTE BIOLOGY, 2022; 111 (6)

Severe coronavirus disease 2019 (COVID-19) is characterized by lung injury, cytokine storm, and increased neutrophil-to-lymphocyte ratio (NLR). Curren......

JIF:4.277

PD-L1 expression in peripheral blood granulocytes at diagnosis as prognostic factor in classical Hodgkin lymphoma

期刊: JOURNAL OF LEUKOCYTE BIOLOGY, 2022; 112 (3)

Hodgkin lymphoma (HL) is a neoplastic disease in which the inflammatory microenvironment plays a pivotal role in the tumorigenesis. Neutrophilia is a ......

JIF:4.277

CAR NK-92 cells targeting DLL3 kill effectively small cell lung cancer cells in vitro and in vivo

期刊: JOURNAL OF LEUKOCYTE BIOLOGY, 2022; 112 (4)

Small cell lung cancer (SCLC) is characterized by a high relapse rate, drug tolerance, and limited treatment choices. Chimeric antigen receptor (CAR)-......

JIF:4.277

Neutrophil-derived extracellular vesicles promote feed-forward inflammasome signaling in cystic fibrosis airways

期刊: JOURNAL OF LEUKOCYTE BIOLOGY, 2022; 112 (4)

Cystic fibrosis (CF) airways feature high extracellular levels of the IL-1 family of proinflammatory mediators. These mediators are cleavage products ......

JIF:4.277

A curious case of cyclin-dependent kinases in neutrophils

期刊: JOURNAL OF LEUKOCYTE BIOLOGY, 2022; 111 (5)

Neutrophils are terminally differentiated, short-lived white blood cells critical for innate immunity. Although cyclin-dependent kinases (CDKs) are ty......

JIF:4.277

The phosphoinositide-3-kinase (PI3K)-delta inhibitor seletalisib impairs monocyte-derived dendritic cells maturation, APC function, and promotes their migration to CCR7 and CXCR4 ligands

期刊: JOURNAL OF LEUKOCYTE BIOLOGY, 2022; 112 (3)

PI3K pathway plays a crucial role in dendritic cells (DCs) functions, as it regulates different cellular processes, such as maturation and cytokines p......

JIF:4.277

Alveolar macrophage-derived NRP2 curtails lung injury while boosting host defense in bacterial pneumonia

期刊: JOURNAL OF LEUKOCYTE BIOLOGY, 2022; 112 (3)

Clearance of airway intruders by immune cells is required to resolve infectious pneumonia. However, the molecular mechanisms underlying this process r......

JIF:4.277

Acteoside promotes B cell-derived IL-10 production and ameliorates autoimmunity

期刊: JOURNAL OF LEUKOCYTE BIOLOGY, 2022; 112 (4)

IL-10-producing regulatory B (Breg) cells are well recognized for maintaining immune tolerance. The impaired Breg cell function with decreased IL-10-p......

JIF:4.277

c-Rel-dependent monocytes are potent immune suppressor cells in cancer

期刊: JOURNAL OF LEUKOCYTE BIOLOGY, 2022; 112 (4)

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of leukocytes that are important for tumorigenesis and tumor immunotherapy. Th......

JIF:4.277

IL-22 and Lactobacillus delbrueckii mitigate alcohol-induced exacerbation of DSS-induced colitis

期刊: JOURNAL OF LEUKOCYTE BIOLOGY, 2022; 112 (6)

Ulcerative colitis (UC) is characterized by cycles of active disease flare and inactive disease remission. During UC remission, IL-22 is up-regulated,......

JIF:4.277

TRB sequences targeting ORF1a/b are associated with disease severity in hospitalized COVID-19 patients

期刊: JOURNAL OF LEUKOCYTE BIOLOGY, 2022; 111 (1)

The potential protective or pathogenic role of the adaptive immune response to SARS-CoV-2 infection has been vigorously debated. While COVID-19 patien......

JIF:4.277

Campylobacter jejuni induces differentiation of human neutrophils to the CD16(hi)/CD62L(lo) subtype

期刊: JOURNAL OF LEUKOCYTE BIOLOGY, 2022; 112 (6)

The discovery of neutrophil subtypes has expanded what is known about neutrophil functions, yet there is still much to learn about the role of these s......

JIF:4.277

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