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Intrinsically altered lung-resident gamma delta T cells control lung melanoma by producing interleukin-17A in the elderly

期刊: AGING CELL, 2020; 19 (2)

Cancer is an age-associated disease, potentially related to the altered immune system of elderly individuals. However, cancer has gradually decreased ......

Metformin mediates cardioprotection against aging-induced ischemic necroptosis

期刊: AGING CELL, 2020; 19 (2)

Necroptosis is crucially involved in severe cardiac pathological conditions. However, whether necroptosis contributes to age-related intolerance to is......

A high-fat diet reverses metabolic disorders and premature aging by modulating insulin and IGF1 signaling in SIRT6 knockout mice

期刊: AGING CELL, 2020; 19 (3)

Mammalian sirtuin 6 (SIRT6) is involved in the regulation of many essential processes, especially metabolic homeostasis. SIRT6 knockout mice undergo p......

Mitochondrial function in skeletal myofibers is controlled by a TRF2-SIRT3 axis over lifetime

期刊: AGING CELL, 2020; 19 (3)

Telomere shortening follows a developmentally regulated process that leads to replicative senescence of dividing cells. However, whether telomere chan......

TRPV1 activation alleviates cognitive and synaptic plasticity impairments through inhibiting AMPAR endocytosis in APP23/PS45 mouse model of Alzheimer's disease

期刊: AGING CELL, 2020; 19 (3)

Alzheimer's disease (AD) is one of the most common causes of neurodegenerative diseases in the elderly. The accumulation of amyloid-beta (A beta) pept......

Sexual dimorphism in the nutritional requirement for adult lifespan in Drosophila melanogaster

期刊: AGING CELL, 2020; 19 (3)

The nutritional requirements of Drosophila have mostly been studied for development and reproduction, but the minimal requirements for adult male and ......

LSD1 contributes to programmed oocyte death by regulating the transcription of autophagy adaptor SQSTM1/p62

期刊: AGING CELL, 2020; 19 (3)

In female mammals, the size of the initially established primordial follicle (PF) pool within the ovaries determines the reproductive lifespan of fema......

Increased miR-34c mediates synaptic deficits by targeting synaptotagmin 1 through ROS-JNK-p53 pathway in Alzheimer's Disease

期刊: AGING CELL, 2020; 19 (3)

Alzheimer's disease (AD) and cancer have inverse relationship in many aspects. Some tumor suppressors, including miR-34c, are decreased in cancer but ......

Age attenuates the T-type Ca(V)3.2-RyR axis in vascular smooth muscle

期刊: AGING CELL, 2020; 19 (4)

Caveolae position Ca(V)3.2 (T-type Ca2+ channel encoded by the alpha-3.2 subunit) sufficiently close to RyR (ryanodine receptors) for extracellular Ca......

miR-155-5p inhibition rejuvenates aged mesenchymal stem cells and enhances cardioprotection following infarction

期刊: AGING CELL, 2020; 19 (4)

Aging impairs the functions of human mesenchymal stem cells (MSCs), thereby severely reducing their beneficial effects on myocardial infarction (MI). ......

Deterioration of hematopoietic autophagy is linked to osteoporosis

期刊: AGING CELL, 2020; 19 (5)

Hematopoietic disorders are known to increase the risk of complications such as osteoporosis. However, a direct link between hematopoietic cellular di......

Mossy cell synaptic dysfunction causes memory imprecision via miR-128 inhibition of STIM2 in Alzheimer's disease mouse model

期刊: AGING CELL, 2020; 19 (5)

Recently, we have reported that dentate mossy cells (MCs) control memory precision via directly and functionally innervating local somatostatin (SST) ......

C9orf72 associates with inactive Rag GTPases and regulates mTORC1-mediated autophagosomal and lysosomal biogenesis

期刊: AGING CELL, 2020; 19 (4)

GGGGCC repeat expansion in C9orf72 is the most common genetic cause in both frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), two......

The involvement of stress granules in aging and aging-associated diseases

期刊: AGING CELL, 2020; 19 (4)

Stress granules (SGs) are nonmembrane assemblies formed in cells in response to stress conditions. SGs mainly contain untranslated mRNA and a variety ......

Activation of epidermal growth factor receptor signaling mediates cellular senescence induced by certain pro-inflammatory cytokines

期刊: AGING CELL, 2020; 19 (5)

It is well established that inflammation in the body promotes organism aging, and recent studies have attributed a similar effect to senescent cells. ......

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