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The dynamic cycle of bacterial translation initiation factor IF3

期刊: NUCLEIC ACIDS RESEARCH, 2021; 49 (12)

Initiation factor IF3 is an essential protein that enhances the fidelity and speed of bacterial mRNA translation initiation. Here, we describe the dyn......

Crystal structure and functional implication of a bacterial cyclic AMP-AMP-GMP synthetase

期刊: NUCLEIC ACIDS RESEARCH, 2021; 49 (8)

Mammalian cyclic GMP-AMP synthase (cGAS) and its homologue dinucleotide cyclase in Vibrio cholerae (VcDncV) produce cyclic dinucleotides (CDNs) that p......

Role of a local transcription factor in governing cellular carbon/nitrogen homeostasis in Pseudomonas fluorescens

期刊: NUCLEIC ACIDS RESEARCH, 2021; 49 (6)

Autoactivation of two-component systems (TCSs) can increase the sensitivity to signals but inherently cause a delayed response. Here, we describe a un......

LipidSig: a web-based tool for lipidomic data analysis

期刊: NUCLEIC ACIDS RESEARCH, 2021; 49 (W1)

With the continuing rise of lipidomic studies, there is an urgent need for a useful and comprehensive tool to facilitate lipidomic data analysis. The ......

iNetModels 2.0: an interactive visualization and database of multi-omics data

期刊: NUCLEIC ACIDS RESEARCH, 2021; 49 (W1)

It is essential to reveal the associations between various omics data for a comprehensive understanding of the altered biological process in human wel......

RNA pull-down confocal nanoscanning (RP-CONA) detects quercetin as pri-miR-7/HuR interaction inhibitor that decreases alpha-synuclein levels

期刊: NUCLEIC ACIDS RESEARCH, 2021; 49 (11)

RNA-protein interactions are central to all gene expression processes and contribute to a variety of human diseases. Therapeutic approaches targeting ......

Measuring nonhomologous end-joining, homologous recombination and alternative end-joining simultaneously at an endogenous locus in any transfectable human cell

期刊: NUCLEIC ACIDS RESEARCH, 2021; 49 (13)

Double strand break (DSB) repair primarily occurs through 3 pathways: non-homologous end-joining (NHEJ), alternative end-joining (Alt-EJ), and homolog......

SDC mediates DNA methylation-controlled clock pace by interacting with ZTL in Arabidopsis

期刊: NUCLEIC ACIDS RESEARCH, 2021; 49 (7)

Molecular bases of eukaryotic circadian clocks mainly rely on transcriptional-translational feedback loops (TTFLs), while epigenetic codes also play c......

A native, highly active Tc1/mariner transposon from zebrafish (ZB) offers an efficient genetic manipulation tool for vertebrates

期刊: NUCLEIC ACIDS RESEARCH, 2021; 49 (4)

New genetic tools and strategies are currently under development to facilitate functional genomics analyses. Here, we describe an active member of the......

iLearnPlus: a comprehensive and automated machine-learning platform for nucleic acid and protein sequence analysis, prediction and visualization

期刊: NUCLEIC ACIDS RESEARCH, 2021; 49 (10)

Sequence-based analysis and prediction are fundamental bioinformatic tasks that facilitate understanding of the sequence(-structure)-function paradigm......

Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-ExoN domain reveals an exoribonuclease with both structural and functional integrity

期刊: NUCLEIC ACIDS RESEARCH, 2021; 49 (9)

The emergence of SARS-CoV-2 infection has posed unprecedented threat to global public health. The virus-encoded non-structural protein 14 (nsp14) is a......

PlantDeepSEA, a deep learning-based web service to predict the regulatory effects of genomic variants in plants

期刊: NUCLEIC ACIDS RESEARCH, 2021; 49 (W1)

Characterizing regulatory effects of genomic variants in plants remains a challenge. Although several tools based on deep-learning models and large-sc......

MiniCAFE, a CRISPR/Cas9-based compact and potent transcriptional activator, elicits gene expression in vivo

期刊: NUCLEIC ACIDS RESEARCH, 2021; 49 (7)

CRISPR-mediated gene activation (CRISPRa) is a promising therapeutic gene editing strategy without inducing DNA double-strand breaks (DSBs). However, ......

Role of CxxC-finger protein 1 in establishing mouse oocyte epigenetic landscapes

期刊: NUCLEIC ACIDS RESEARCH, 2021; 49 (5)

During oogenesis, oocytes gain competence and subsequently undergo meiotic maturation and prepare for embryonic development; trimethylated histone H3 ......

GEPIA2021: integrating multiple deconvolution-based analysis into GEPIA

期刊: NUCLEIC ACIDS RESEARCH, 2021; 49 (W1)

In 2017, we released GEPIA (Gene Expression Profiling Interactive Analysis) webserver to facilitate the widely used analyses based on the bulk gene ex......

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