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ZBTB7A suppresses glioblastoma tumorigenesis through the transcriptional repression of EPB41L5

期刊: EXPERIMENTAL AND MOLECULAR MEDICINE, 2023; 55 (1)

Glioblastoma multiforme (GBM), the most aggressive and malignant glioma, has a poor prognosis. Although patients with GBM are treated with surgery, ch......

Grave-to-cradle: human embryonic lineage tracing from the postmortem body

期刊: EXPERIMENTAL AND MOLECULAR MEDICINE, 2023; 55 (1)

Curiosity concerning the process of human creation has been around for a long time. Relevant questions seemed to be resolved with the knowledge of how......

Micrococcus luteus-derived extracellular vesicles attenuate neutrophilic asthma by regulating miRNAs in airway epithelial cells

期刊: EXPERIMENTAL AND MOLECULAR MEDICINE, 2023; 55 (1)

Bacterial extracellular vesicles (EVs) have been shown to regulate various pulmonary diseases, but their functions in asthma remain uncertain. To demo......

Inhibiting nighttime melatonin and boosting cortisol increase patrolling monocytes, phagocytosis, and myelination in a murine model of multiple sclerosis

期刊: EXPERIMENTAL AND MOLECULAR MEDICINE, 2023; 55 (1)

Conflicting results on melatonin synthesis in multiple sclerosis (MS) have been reported due to variabilities in patient lifestyles, which are not con......

CAR links hypoxia signaling to improved survival after myocardial infarction

期刊: EXPERIMENTAL AND MOLECULAR MEDICINE, 2023; 55 (3)

Heart attack: Inhibiting cell contact protein may limit damageDuring a heart attack the death of heart muscle cells causes lesions that transform into......

Double-edged sword: ?d T cells in mucosal homeostasis and disease

期刊: EXPERIMENTAL AND MOLECULAR MEDICINE, 2023; 55 (9)

The mucosa is a tissue that covers numerous body surfaces, including the respiratory tract, digestive tract, eye, and urogenital tract. Mucosa is in d......

PLCγ1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III

期刊: EXPERIMENTAL AND MOLECULAR MEDICINE, 2023; 55 (11)

Dopamine neurons are essential for voluntary movement, reward learning, and motivation, and their dysfunction is closely linked to various psychologic......

Mitochondrial nucleic acids in innate immunity and beyond

期刊: EXPERIMENTAL AND MOLECULAR MEDICINE, 2023; ()

Mitochondria participate in a wide range of cellular processes. One essential function of mitochondria is to be a platform for antiviral signaling pro......

ANGPTL4 stabilizes atherosclerotic plaques and modulates the phenotypic transition of vascular smooth muscle cells through KLF4 downregulation

期刊: EXPERIMENTAL AND MOLECULAR MEDICINE, 2023; 55 (2)

Atherosclerosis, the leading cause of death, is a vascular disease of chronic inflammation. We recently showed that angiopoietin-like 4 (ANGPTL4) prom......

An agonistic anti-Tie2 antibody suppresses the normal-to-tumor vascular transition in the glioblastoma invasion zone

期刊: EXPERIMENTAL AND MOLECULAR MEDICINE, 2023; 55 (2)

Brain tumours: antibody blocks blood vessel abnormalityAn antibody targeting key signalling pathways could prevent brain tumor vessels from being abno......

Whole-genome sequencing reveals an association between small genomic deletions and an increased risk of developing Parkinson's disease

期刊: EXPERIMENTAL AND MOLECULAR MEDICINE, 2023; 55 (3)

Parkinson's disease: genetic risk factors in a Korean populationA whole-genome sequencing study of Korean individuals with Parkinson's disease (PD) ha......

Crystal structure of LRG1 and the functional significance of LRG1 glycan for LPHN2 activation

期刊: EXPERIMENTAL AND MOLECULAR MEDICINE, 2023; 55 (5)

The serum glycoprotein leucine-rich alpha-2-glycoprotein 1 (LRG1), primarily produced by hepatocytes and neutrophils, is a multifunctional protein tha......

Functional roles of sphingolipids in immunity and their implication in disease

期刊: EXPERIMENTAL AND MOLECULAR MEDICINE, 2023; 55 (6)

Immunology: Membrane lipids in immunity and diseaseAdvances in laboratory techniques and genetic databases are revealing the vital roles played by a l......

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