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Inflammatory ER stress responses dictate the immunopathogenic progression of systemic candidiasis

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2023; 133 (17)

Recognition of pathogen-associated molecular patterns can trigger the inositol-requiring enzyme 1 alpha (IRE1 alpha) arm of the endoplasmic reticulum ......

Mechanosensing Piezo channels in gastrointestinal disorders

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2023; 133 (19)

All cells in the body are exposed to physical force in the form of tension, compression, gravity, shear stress, or pressure. Cells convert these mecha......

FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2023; 133 (22)

The heterogeneity of cancer stem cells (CSCs) within tumors presents a challenge in therapeutic targeting. To decipher the cellular plasticity that fu......

Targeting eIF4A triggers an interferon response to synergize with chemotherapy and suppress triple-negative breast cancer

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2023; 133 (24)

Protein synthesis is frequently dysregulated in cancer and selective inhibition of mRNA translation represents an attractive cancer therapy. Here, we ......

Waking immune-resistant tumors with neddylation

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2023; 133 (4)

The CD47/signal regulatory protein alpha (SIRP alpha) axis, which functions as an inhibitory phagocytosis checkpoint, also serves as a key mediator in......

In situ expansion and reprogramming of Kupffer cells elicit potent tumoricidal immunity against liver metastasis

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2023; 133 (8)

Liver metastasis represents one of the most frequent malignant diseases with no effective treatment. Functional reprogramming of Kupffer cells (KCs), ......

Lysosomal lipid peroxidation regulates tumor immunity

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2023; 133 (8)

Lysosomal inhibition elicited by palmitoyl-protein thioesterase 1 (PPT1) inhibitors such as DC661 can produce cell death, but the mechanism for this i......

Human IAPP is a contributor to painful diabetic peripheral neuropathy

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2023; 133 (8)

Peripheral neuropathy is a frequent complication of type 2 diabetes mellitus (T2DM). We investigated whether human islet amyloid polypeptide (hIAPP), ......

A parathyroid hormone/salt-inducible kinase signaling axis controls renal vitamin D activation and organismal calcium homeostasis

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2023; 133 (9)

The renal actions of parathyroid hormone (PTH) promote 1,25-vitamin D generation; however, the signaling mechanisms that control PTH-dependent vitamin......

Loss of STAT2 may be dangerous in a world filled with viruses

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2023; 133 (12)

Type I IFNs, a family of cytokines that signal through a single receptor and signaling mechanism, were originally named for their ability to interfere......

Viral vector-mediated expression of NaV1.1, after seizure onset, reduces epilepsy in mice with Dravet syndrome

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2023; 133 (12)

Dravet syndrome (DS), an intractable childhood epileptic encephalopathy with a high fatality rate, is typically caused by loss-of-function mutations i......

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