期刊: JOURNAL OF CLINICAL INVESTIGATION, 2023; 133 (17)
Recognition of pathogen-associated molecular patterns can trigger the inositol-requiring enzyme 1 alpha (IRE1 alpha) arm of the endoplasmic reticulum ......
期刊: JOURNAL OF CLINICAL INVESTIGATION, 2023; 133 (19)
All cells in the body are exposed to physical force in the form of tension, compression, gravity, shear stress, or pressure. Cells convert these mecha......
期刊: JOURNAL OF CLINICAL INVESTIGATION, 2023; 133 (22)
The heterogeneity of cancer stem cells (CSCs) within tumors presents a challenge in therapeutic targeting. To decipher the cellular plasticity that fu......
期刊: JOURNAL OF CLINICAL INVESTIGATION, 2023; 133 (24)
Protein synthesis is frequently dysregulated in cancer and selective inhibition of mRNA translation represents an attractive cancer therapy. Here, we ......
期刊: JOURNAL OF CLINICAL INVESTIGATION, 2023; 133 (4)
The CD47/signal regulatory protein alpha (SIRP alpha) axis, which functions as an inhibitory phagocytosis checkpoint, also serves as a key mediator in......
期刊: JOURNAL OF CLINICAL INVESTIGATION, 2023; 133 (8)
Liver metastasis represents one of the most frequent malignant diseases with no effective treatment. Functional reprogramming of Kupffer cells (KCs), ......
期刊: JOURNAL OF CLINICAL INVESTIGATION, 2023; 133 (8)
Lysosomal inhibition elicited by palmitoyl-protein thioesterase 1 (PPT1) inhibitors such as DC661 can produce cell death, but the mechanism for this i......
期刊: JOURNAL OF CLINICAL INVESTIGATION, 2023; 133 (8)
Peripheral neuropathy is a frequent complication of type 2 diabetes mellitus (T2DM). We investigated whether human islet amyloid polypeptide (hIAPP), ......
期刊: JOURNAL OF CLINICAL INVESTIGATION, 2023; 133 (9)
The renal actions of parathyroid hormone (PTH) promote 1,25-vitamin D generation; however, the signaling mechanisms that control PTH-dependent vitamin......
期刊: JOURNAL OF CLINICAL INVESTIGATION, 2023; 133 (12)
Type I IFNs, a family of cytokines that signal through a single receptor and signaling mechanism, were originally named for their ability to interfere......
期刊: JOURNAL OF CLINICAL INVESTIGATION, 2023; 133 (12)
Dravet syndrome (DS), an intractable childhood epileptic encephalopathy with a high fatality rate, is typically caused by loss-of-function mutations i......