筛选条件 共查询到230条结果
排序方式
The deubiquitylase USP2 maintains ErbB2 abundance via counteracting endocytic degradation and represents a therapeutic target in ErbB2-positive breast cancer

期刊: CELL DEATH AND DIFFERENTIATION, 2020; 27 (9)

ErbB2 overexpression identifies a subclass of breast cancer as ErbB2-positive that is frequently associated with poor prognosis. Current ErbB2-targete......

Hippo kinases MST1 and MST2 control the differentiation of the epididymal initial segment via the MEK-ERK pathway

期刊: CELL DEATH AND DIFFERENTIATION, 2020; 27 (10)

Although the roles of the Hippo pathway in organogenesis and tumorigenesis have been well studied in multiple organs, its role in sperm maturation and......

HSPA12A attenuates lipopolysaccharide-induced liver injury through inhibiting caspase-11-mediated hepatocyte pyroptosis via PGC-1 alpha-dependent acyloxyacyl hydrolase expression

期刊: CELL DEATH AND DIFFERENTIATION, 2020; 27 (9)

Liver dysfunction is strongly associated with poor survival of sepsis patients. Cytosolic lipopolysaccharide (LPS) sensing by Caspase-4/5/11 for pyrop......

Critical role of histone H3 lysine 27 demethylase Kdm6b in the homeostasis and function of medullary thymic epithelial cells

期刊: CELL DEATH AND DIFFERENTIATION, 2020; 27 (10)

Medullary thymic epithelial cells (mTECs) play a central role in the establishment of T cell central immunological tolerance by promiscuously expressi......

Circular RNA cESRP1 sensitises small cell lung cancer cells to chemotherapy by sponging miR-93-5p to inhibit TGF-beta signalling

期刊: CELL DEATH AND DIFFERENTIATION, 2020; 27 (5)

Circular RNAs (circRNAs) are novel RNA molecules that play important roles in chemoresistance in different cancers, including breast and gastric cance......

Tumor suppressor ZHX2 inhibits NAFLD-HCC progression via blocking LPL-mediated lipid uptake

期刊: CELL DEATH AND DIFFERENTIATION, 2020; 27 (5)

Non-alcoholic fatty liver disease (NAFLD) leads to hepatocellular carcinoma (HCC). However, the underlying mechanism remains largely unclear. Here, we......

Epigenetic regulation of the Warburg effect by H2B monoubiquitination

期刊: CELL DEATH AND DIFFERENTIATION, 2020; 27 (5)

Cancer cells reprogram their energy metabolic system from the mitochondrial oxidative phosphorylation (OXPHOS) pathway to a glucose-dependent aerobic ......

Zfp422 promotes skeletal muscle differentiation by regulating EphA7 to induce appropriate myoblast apoptosis

期刊: CELL DEATH AND DIFFERENTIATION, 2020; 27 (5)

Zinc finger protein 422 (Zfp422) is a widely expressed zinc finger protein that serves as a transcriptional factor to regulate downstream gene express......

Functional interplay between p53 and Delta 133p53 in adaptive stress response

期刊: CELL DEATH AND DIFFERENTIATION, 2020; 27 (5)

Apart from its well-known prodeath activity, p53 is also implicated in promoting cell survival. How p53 can mediate such seemingly opposing effects is......

Satb2 is required for the regionalization of retrosplenial cortex

期刊: CELL DEATH AND DIFFERENTIATION, 2020; 27 (5)

The retrosplenial cortex (Rsp) is a transitional cortex located between the neocortex and archicortex, but the molecular mechanism specifying Rsp from......

Membrane-bound TNF mediates microtubule-targeting chemotherapeutics-induced cancer cytolysis via juxtacrine inter-cancer-cell death signaling

期刊: CELL DEATH AND DIFFERENTIATION, 2020; 27 (5)

Microtubule-targeting agents (MTAs) are a class of most widely used chemotherapeutics and their mechanism of action has long been assumed to be mitoti......

Uterine deficiency of high-mobility group box-1 (HMGB1) protein causes implantation defects and adverse pregnancy outcomes

期刊: CELL DEATH AND DIFFERENTIATION, 2020; 27 (5)

A reciprocal communication between the implantation-competent blastocyst and the receptive uterus is essential to successful implantation and pregnanc......

Chemical activation of SAT1 corrects diet-induced metabolic syndrome

期刊: CELL DEATH AND DIFFERENTIATION, 2020; 27 (10)

The pharmacological targeting of polyamine metabolism is currently under the spotlight for its potential in the prevention and treatment of several ag......

共230条页码: 1/16页15条/页
打开APP