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Evidence for rate-dependent filtering of global extrinsic noise by biochemical reactions in mammalian cells

期刊: MOLECULAR SYSTEMS BIOLOGY, 2020; 16 (5)

Recent studies have revealed that global extrinsic noise arising from stochasticity in the intracellular biochemical environment plays a critical role......

CIGAR-seq, a CRISPR/Cas-based method for unbiased screening of novel mRNA modification regulators

期刊: MOLECULAR SYSTEMS BIOLOGY, 2020; 16 (11)

Cellular RNA is decorated with over 170 types of chemical modifications. Many modifications in mRNA, including m(6)A and m(5)C, have been associated w......

Isoform-resolved correlation analysis between mRNA abundance regulation and protein level degradation

期刊: MOLECULAR SYSTEMS BIOLOGY, 2020; 16 (3)

Profiling of biological relationships between different molecular layers dissects regulatory mechanisms that ultimately determine cellular function. T......

The acute effect of metabolic cofactor supplementation: a potential therapeutic strategy against non-alcoholic fatty liver disease

期刊: MOLECULAR SYSTEMS BIOLOGY, 2020; 16 (4)

The prevalence of non-alcoholic fatty liver disease (NAFLD) continues to increase dramatically, and there is no approved medication for its treatment.......

Pan-tissue analysis of allelic alternative polyadenylation suggests widespread functional regulation

期刊: MOLECULAR SYSTEMS BIOLOGY, 2020; 16 (4)

Alternative polyadenylation (APA) is a major layer of gene regulation. However, it has recently been argued that most APA represents molecular noise. ......

Systems approach reveals photosensitivity and PER2 level as determinants of clock-modulator efficacy

期刊: MOLECULAR SYSTEMS BIOLOGY, 2019; 15 (7)

In mammals, the master circadian clock synchronizes daily rhythms of physiology and behavior with the day-night cycle. Failure of synchrony, which inc......

JIF:9.8

Drug detoxification dynamics explain the postantibiotic effect

期刊: MOLECULAR SYSTEMS BIOLOGY, 2017; 13 (10)

The postantibiotic effect (PAE) refers to the temporary suppression of bacterial growth following transient antibiotic treatment. This effect has been......

JIF:8.5

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