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Eukaryotic ribosome quality control system: a potential therapeutic target for human diseases

期刊: INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2022; 18 (6)

Protein homeostasis is well accepted as the prerequisite for proper operation of various life activities. As the main apparatus of protein translation......

JIF:6.087

CPNE8 Promotes Gastric Cancer Metastasis by Modulating Focal Adhesion Pathway and Tumor Microenvironment

期刊: INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2022; 18 (13)

Little is known about the oncogenic role or biological function of copine VIII (CPNE8) in gastric cancer (GC). Based on TCGA database, we screened for......

JIF:6.087

SPC25 promotes proliferation and stemness of hepatocellular carcinoma cells via the DNA-PK/ AKT/Notch1 signaling pathway

期刊: INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2022; 18 (14)

The imbalance of kinetochore-microtubule attachment during cell mitosis is a response to the initiation and progression of human cancers. Spindle comp......

JIF:6.087

FTO-mediated autophagy promotes progression of clear cell renal cell carcinoma via regulating SIK2 mRNA stability

期刊: INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2022; 18 (15)

The progression of clear cell renal cell carcinoma (ccRCC) remains a major challenge in clinical practice, and elucidation of the molecular drivers of......

JIF:6.087

RhoJ facilitates angiogenesis in glioblastoma via JNK/VEGFR2 mediated activation of PAK and ERK signaling pathways

期刊: INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2022; 18 (3)

Glioblastoma (GBM) is a highly vascularized malignant tumor that depends on new blood vessel formation. Small molecules targeting the angiogenic proce......

JIF:6.087

PRMT5 acts as a tumor suppressor by inhibiting Wnt/?-catenin signaling in murine gastric tumorigenesis

期刊: INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2022; 18 (11)

Previous studies have demonstrated the in vitro oncogenic role of protein arginine methyltransferase 5 (PRMT5) in gastric cancer cell lines. The in vi......

JIF:6.087

Ferroptosis-associated molecular classification characterized by distinct tumor microenvironment profiles in colorectal cancer

期刊: INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2022; 18 (5)

Ferroptosis is a non-apoptotic form of cell death recognized in recent years. Nonetheless, the potential role of ferroptosis-associated genes in immun......

JIF:6.087

Long noncoding RNA Linc01612 represses hepatocellular carcinoma progression by regulating miR-494/ATF3/p53 axis and promoting ubiquitination of YBX1

期刊: INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2022; 18 (7)

Long noncoding RNAs (lncRNAs) play an important role in the progression of hepatocellular carcinoma (HCC). Linc01612 is a novel lncRNA that function r......

JIF:6.087

Jwa participates the maintenance of intestinal epithelial homeostasis via ERK/FBXW7-mediated NOTCH1/PPAR gamma/STAT5 axis and acts as a novel putative aging related gene

期刊: INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2022; 18 (14)

The intestinal epithelium is a rapid self-renewal and regenerated tissue of which the structural integrity is beneficial for maintaining health. The i......

JIF:6.087

Platelet-derived extracellular vesicles inhibit ferroptosis and promote distant metastasis of nasopharyngeal carcinoma by upregulating ITGB3

期刊: INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2022; 18 (15)

Nasopharyngeal carcinoma (NPC) is a malignancy with high metastatic and invasive nature. Distant metastasis contributes substantially to treatment fai......

JIF:6.087

The regulatory function of piRNA/PIWI complex in cancer and other human diseases: The role of DNA methylation

期刊: INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2022; 18 (8)

Piwi-interacting RNAs (piRNAs) are a class of short chain noncoding RNAs that are constituted by 26-30 nucleotides (nt) and can couple with PIWI prote......

JIF:6.087

Recent advances in organotypic tissue slice cultures for anticancer drug development

期刊: INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2022; 18 (15)

Organotypic tissue slice culture is established from animal or patient tissues and cultivated in an in vitro ecosystem. This technique has made countl......

JIF:6.087

HJURP Promotes Malignant Progression and Mediates Sensitivity to Cisplatin and WEE1-inhibitor in Serous Ovarian Cancer

期刊: INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2022; 18 (3)

Ovarian cancer is the most lethal gynecological malignancy. Recurrence and chemoresistance are tough challenges leading to poor prognosis. HJURP is a ......

JIF:6.087

Humoral and Cellular Immune Responses of COVID-19 vaccines against SARS-Cov-2 Omicron variant: a systemic review

期刊: INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2022; 18 (12)

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has undergone multiple mutations since its emergence, and its latest variant, Omicron (B.......

JIF:6.087

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