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Suppressing long noncoding RNA OGRU ameliorates diabetic retinopathy by inhibition of oxidative stress and inflammation via miR-320/USP14 axis

期刊: FREE RADICAL BIOLOGY AND MEDICINE, 2021; 169 ()

Long noncoding RNAs (lncRNAs) are important regulators in various diseases including diabetic retinopathy (DR). In this study, DR patients exhibited s......

Redox environment metabolomic evaluation (REME) of the heart after myocardial ischemia/reperfusion injury

期刊: FREE RADICAL BIOLOGY AND MEDICINE, 2021; 173 ()

Myocardial ischemia/reperfusion injury (MIRI) is closely related to oxidative stress. However, the redox environment of the heart has not been evaluat......

MAPK15-ULK1 signaling regulates mitophagy of airway epithelial cell in chronic obstructive pulmonary disease

期刊: FREE RADICAL BIOLOGY AND MEDICINE, 2021; 172 ()

Airway epithelial mitochondrial oxidative stress and damage is an important pathology in chronic obstructive pulmonary disease (COPD). Mitophagy invol......

Recent advances in Extracellular Vesicles and their involvements in vasculitis

期刊: FREE RADICAL BIOLOGY AND MEDICINE, 2021; 171 ()

Systemic vasculitis is a heterogeneous group of multisystem autoimmune disorders characterized by inflammation of blood vessels. Although many progres......

Carnosine dipeptidase II (CNDP2) protects cells under cysteine insufficiency by hydrolyzing glutathione-related peptides

期刊: FREE RADICAL BIOLOGY AND MEDICINE, 2021; 174 ()

The knockout (KO) of the cystine transporter xCT causes ferroptosis, a type of iron-dependent necrotic cell death, in mouse embryonic fibroblasts, but......

Molecular mechanisms underlying health benefits of tea compounds

期刊: FREE RADICAL BIOLOGY AND MEDICINE, 2021; 172 ()

Tea is one of the three most widely consumed beverages in the world, not only because of its unique flavor but also due to its various health benefits......

Dehydroepiandrosterone alleviates intestinal inflammatory damage via GPR30-mediated Nrf2 activation and NLRP3 inflammasome inhibition in colitis mice

期刊: FREE RADICAL BIOLOGY AND MEDICINE, 2021; 172 ()

Dehydroepiandrosterone (DHEA) is a popular dietary supplement that has anti-inflammatory, anti-oxidant and immune-regulating role; meanwhile, it also ......

4,4 '-Dimethoxychalcone regulates redox homeostasis by targeting riboflavin metabolism in Parkinson's disease therapy

期刊: FREE RADICAL BIOLOGY AND MEDICINE, 2021; 174 ()

Oxidative stress damage plays a pivotal role in Parkinson's disease (PD) pathogenesis. Previously, we developed a blood brain barrier-penetrating pept......

Menadione inhibits thioredoxin reductase 1 via arylation at the Sec(498) residue and enhances both NADPH oxidation and superoxide production in Sec(498) to Cys(498) substitution

期刊: FREE RADICAL BIOLOGY AND MEDICINE, 2021; 172 ()

The selenoprotein thioredoxin reductase 1 (TrxR1; TXNRD1) participates in multiple cellular processes and is regarded as a cellular target in anti-tum......

Crosstalk between reactive oxygen species and Dynamin-related protein 1 in periodontitis

期刊: FREE RADICAL BIOLOGY AND MEDICINE, 2021; 172 ()

Excessive generation of reactive oxygen species (ROS) have great impacts on the development of periodontitis. Dynamin-related protein 1 (Drp1) mediate......

Aging lens epithelium is susceptible to ferroptosis

期刊: FREE RADICAL BIOLOGY AND MEDICINE, 2021; 167 ()

Age-related cataracts (ARC) are the primary cause of blindness worldwide, and oxidative stress is considered the central pathogenesis of age-related c......

Selective intra-arterial brain cooling induces cerebral protection against ischemia/reperfusion injury through SENP1-Sirt3 signaling

期刊: FREE RADICAL BIOLOGY AND MEDICINE, 2021; 171 ()

Background: Although it is well known that selective intra-arterial cooling (SI-AC) elicits cerebral protection against ischemia/reperfusion (I/R) inj......

Protective autophagy attenuates soft substrate-induced apoptosis through ROS/JNK signaling pathway in breast cancer cells

期刊: FREE RADICAL BIOLOGY AND MEDICINE, 2021; 172 ()

Tumor microenvironments are characterized not only in terms of chemical composition, but also by physical properties such as stiffness, which influenc......

Glycyrrhetinic acid induces oxidative/nitrative stress and drives ferroptosis through activating NADPH oxidases and iNOS, and depriving glutathione in triple-negative breast cancer cells

期刊: FREE RADICAL BIOLOGY AND MEDICINE, 2021; 173 ()

Reactive oxygen species (ROS)/reactive nitrogen species (RNS)-mediated ferroptosis becomes a novel effective target for anti-cancer treatment. In the ......

Bach2 regulates autophagy to modulate UVA-induced photoaging in skin fibroblasts

期刊: FREE RADICAL BIOLOGY AND MEDICINE, 2021; 169 ()

Senescence is a cellular process that can be initiated by certain stressors such as UVA irradiation. The mechanism by which skin cells protect themsel......

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