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Arctigenin mitigates insulin resistance by modulating the IRS2/GLUT4 pathway via TLR4 in type 2 diabetes mellitus mice

期刊: INTERNATIONAL IMMUNOPHARMACOLOGY, 2023; 114 ()

Arctigenin (AR), extracted from Arctium lappa L. (Burdock), is a folk herbal medicine used to treat diabetes. However, its mechanism of action has rem......

Sevoflurane protects against intracerebral hemorrhage via microRNA-133b/FOXO4/BCL2 axis

期刊: INTERNATIONAL IMMUNOPHARMACOLOGY, 2023; 114 ()

The application of Sevoflurane (Sev) in neurological diseases has been documented. We herein clarified the role of Sev in intracerebral hemorrhage (IC......

Salidroside protects pancreatic ?-cells against pyroptosis by regulating the NLRP3/GSDMD pathway in diabetic conditions

期刊: INTERNATIONAL IMMUNOPHARMACOLOGY, 2023; 114 ()

The NACHT, LRP, and PYD domains-containing protein 3 (NLRP3) inflammasome-evoked chronic inflammation is involved in the pathogenesis of diabetes mell......

Thymosin alpha1 use in adult COVID-19 patients: A systematic review and meta-analysis on clinical outcomes

期刊: INTERNATIONAL IMMUNOPHARMACOLOGY, 2023; 114 ()

Objective: Thymosin alpha1 (Ta1) is widely used to treat patients with coronavirus disease 2019 (COVID-19), however, its effect remains unclear. This ......

Effect of spermidine on radiation-induced long-term bone marrow cell injury

期刊: INTERNATIONAL IMMUNOPHARMACOLOGY, 2023; 114 ()

Objective: Spermidine, a natural polyamine, possesses anti-oxidant, autophagy-regulation, and anti-aging properties. Elevated levels of oxidative stre......

C1q/tumor necrosis factor-related protein-6 exerts protective effects on myocardial ischemia-reperfusion injury through the modulation of the Akt-GSK-3?-Nrf2 signaling cascade

期刊: INTERNATIONAL IMMUNOPHARMACOLOGY, 2023; 115 ()

C1q/tumor necrosis factor-related protein-6 (CTRP6) is a multifunctional protein that plays a pivotal role in diverse physiological and pathological p......

Cinnamaldehyde modulates host immunoinflammatory responses in rat ligature-induced periodontitis and peripheral blood mononuclear cell models

期刊: INTERNATIONAL IMMUNOPHARMACOLOGY, 2023; 115 ()

Cinnamaldehyde is a natural product with anti-inflammatory and immune-modulatory properties, known to regulate host responses to bacterial stimuli. Th......

JAK2 inhibitor ameliorates the progression of experimental autoimmune myasthenia gravis and balances Th17/Treg cells via regulating the JAK2/STAT3-AKT/mTOR signaling pathway

期刊: INTERNATIONAL IMMUNOPHARMACOLOGY, 2023; 115 ()

Background: An imbalance in Th17/regulatory T (Treg) cells is the major pathogenic mechanism underlying myasthenia gravis (MG). JAK2 inhibitors select......

EuHD1 protects against inflammatory injury driven by NLRP3 inflammasome

期刊: INTERNATIONAL IMMUNOPHARMACOLOGY, 2023; 115 ()

Non-steroidal anti-inflammatory drugs (NSAIDs) possessing anti-inflammatory, analgesic and antipyretic activities, are widely used in the treatment of......

Apolipoprotein E negatively regulates allergic airway inflammation and remodeling in mice with OVA-induced chronic asthma

期刊: INTERNATIONAL IMMUNOPHARMACOLOGY, 2023; 116 ()

Apolipoprotein E (ApoE) is a corticosteroid-unresponsive gene that negatively regulates ovalbumin (OVA) -induced allergic airway inflammation in mice ......

An insight into the TAM system in Alzheimer?s disease

期刊: INTERNATIONAL IMMUNOPHARMACOLOGY, 2023; 116 ()

The TAM receptors may help delay the progression of Alzheimer's disease (AD). AD is the most common neurodegenerative disease associated with human ag......

MMP9 and STAT1 are biomarkers of the change in immune infiltration after anti-tuberculosis therapy, and the immune status can identify patients with spinal tuberculosis

期刊: INTERNATIONAL IMMUNOPHARMACOLOGY, 2023; 116 ()

Background: Due to a lack of studies on immune-related pathogenesis and a clinical diagnostic model, the diagnosis of Spinal Tuberculosis (STB) remain......

N-acetylserotonin inhibits oxidized mitochondrial DNA-induced neuroinflammation by activating the AMPK/PGC-1?/TFAM pathway in neonatal hypoxic-ischemic brain injury model

期刊: INTERNATIONAL IMMUNOPHARMACOLOGY, 2023; 116 ()

Hypoxic-ischemic encephalopathy (HIE) is a substantial cause of irreversible nerve injury in newborns. As the endogenous precursor of melatonin, N-ace......

Thymosin beta-4-A potential tool in healing middle ear lesions in adult mammals

期刊: INTERNATIONAL IMMUNOPHARMACOLOGY, 2023; 116 ()

Acute tympanic membrane perforations primarily occur due to injury or infection in humans. In acute cases, nearly 80-94 % of the perforations heal spo......

Kynurenine pathway metabolites modulated the comorbidity of IBD and depressive symptoms through the immune response

期刊: INTERNATIONAL IMMUNOPHARMACOLOGY, 2023; 117 ()

Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is defined as chronic inflammation in the gastrointestinal tract. ......

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