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Human CD3(+)CD56(+)NKT-like cells express a range of complement receptors and C3 activation has negative effects on these cell activity and effector function

期刊: HUMAN IMMUNOLOGY, 2021; 82 (9)

CD3(+)CD56(+)NKT-like cells are a rare population of lymphocytes that serve important roles in various types of immune-related diseases, and particula......

Association of polymorphisms of innate immunity-related genes and tuberculosis susceptibility in Mongolian population

期刊: HUMAN IMMUNOLOGY, 2021; 82 (4)

Backgrounds: Genetic polymorphism of the toll-like receptor 2, 4 (TLR2, TLR4) and natural resistance associated macrophage protein 1 (NRAMP1) genes ma......

Gene expression patterns associated with tumor-infiltrating CD4+and CD8+T cells in invasive breast carcinomas

期刊: HUMAN IMMUNOLOGY, 2021; 82 (4)

Background: Breast carcinoma is one of the most common tumors in women. The immune microenvironment, especially T cell infiltration, is related to the......

Astragalus-mediated stimulation on antigen-presenting cells could result in higher IL-21 production from CXCR5(+) Tfh-like cells and better IL-21-mediated effector functions

期刊: HUMAN IMMUNOLOGY, 2021; 82 (6)

T cells in renal cell carcinoma (RCC) patients display multiple features of impairment and exhaustion. Here, we hypothesize that Astragalus membranace......

Is the level of HLA eplet mismatch a risk factor for graft loss among kidney transplant recipients who have already formed de novo donor specific antibody?

期刊: HUMAN IMMUNOLOGY, 2021; 82 (4)

Eplet mismatches are associated with de novo DSA (dnDSA) and antibody mediated rejection (ABMR) among the general kidney transplant population. Howeve......

How natural selection shapes genetic differentiation in the MHC region: A case study with Native Americans

期刊: HUMAN IMMUNOLOGY, 2021; 82 (7)

The Human Leukocyte Antigen (HLA) loci are extremely well documented targets of balancing selection, yet few studies have explored how selection affec......

Expression profile of Fc receptor-like molecules in patients with IgA nephropathy

期刊: HUMAN IMMUNOLOGY, 2021; 82 (3)

Background: Fc receptor-like (FCRL) molecules were considered to play a role in the pathogenesis of certain autoimmune diseases. Nonetheless, the clin......

Dynamic changes in monocytes subsets in COVID-19 patients

期刊: HUMAN IMMUNOLOGY, 2021; 82 (3)

Background: Coronavirus disease 2019 (COVID-19) is affecting the whole world and threatening human health. We aim to investigate the immunological cha......

The association of gamma delta-T cells with bronchopulmonary dysplasia in premature infants

期刊: HUMAN IMMUNOLOGY, 2021; 82 (1)

Background: As the survival rate of premature infants increases, the incidence of bronchopulmonary dysplasia (BPD), a chronic complication of prematur......

PD-1 silencing improves anti-tumor activities of human mesothelin-targeted CAR T cells

期刊: HUMAN IMMUNOLOGY, 2021; 82 (2)

Chimeric antigen receptor T (CART) cell therapy is a new pillar in cancer therapeutics, and has been successfully used for the treatment of cancers, i......

The B7-H4 gene induces immune escape partly via upregulating the PD-1/Stat3 pathway in non-small cell lung cancer

期刊: HUMAN IMMUNOLOGY, 2020; 81 (5)

Non-small cell lung cancer (NSCLC) is associated with high mortality rates worldwide. The costimulatory molecule, B7-H4, a member of the B7 family, pl......

Implication of IL-17 producing alpha beta T and gamma delta T cells in patients with ovarian cancer

期刊: HUMAN IMMUNOLOGY, 2020; 81 (5)

Objective: To investigate the expression and cellular source of IL-17A in human ovarian cancer (OC), benign ovarian tumor (BOT) and borderline ovarian......

Overrepresentation of highly functional T regulatory cells in patients with nonfunctioning pituitary adenoma

期刊: HUMAN IMMUNOLOGY, 2020; 81 (6)

Nonfunctioning pituitary adenoma is a common intracranial tumor. Though benign in the majority of cases, complications can be excruciating to the affe......

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