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Gain-of-function mutations in RPA1 cause a syndrome with short telomeres and somatic genetic rescue

期刊: BLOOD, 2022; 139 (7)

Human telomere biology disorders (TBD)/short telomere syndromes (STS) are heterogeneous disorders caused by inherited loss-of-function mutations in te......

JIF:7.405

PKM2 promotes neutrophil activation and cerebral thromboinflammation: therapeutic implications for ischemic stroke

期刊: BLOOD, 2022; 139 (8)

There is a critical need for cerebro-protective interventions to improve the suboptimal outcomes of patients with ischemic stroke who have been treate......

JIF:7.405

Nonhuman glycans can regulate anti-factor VIII antibody formation in mice

期刊: BLOOD, 2022; 139 (9)

Recombinant factor VIII (FVIII) products represent a life-saving intervention for patients with hemophilia A. However, patients can develop antibodies......

JIF:7.405

Targeting vulnerabilities of adult T-cell leukemia

期刊: BLOOD, 2022; 139 (10)

In this issue of Blood, Ishio et al(1) identified the genes critical for proliferation and/or survival of adult T-cell leukemia-lymphoma (ATL) cells u......

JIF:7.405

Memory NK cells to forget relapsed AML

期刊: BLOOD, 2022; 139 (11)

In this issue of Blood, Bednarski et al(1) describe the results of a clinical trial of memory-like natural killer (ML NK) cells for children and adole......

JIF:7.405

Oral azacitidine prolongs survival of patients with AML in remission independently of measurable residual disease status

期刊: BLOOD, 2022; 139 (14)

Measurable residual disease (MRD) in patients with acute myeloid leukemia (AML) in remission after intensive chemotherapy is predictive of early relap......

JIF:7.405

Low von Willebrand factor phenotype: the enigma continues

期刊: BLOOD, 2022; 139 (14)

The cause of mildly reduced plasma levels of von Willebrand factor (VWF) has been elusive, but in this issue of Blood, Ng et al(1) describe results of......

JIF:7.405

Granulocyte microvesicles with a high plasmin generation capacity promote clot lysis and improve outcome in septic shock

期刊: BLOOD, 2022; 139 (15)

Microvesicles (MVs) have previously been shown to exert profibrinolytic capacity, which is increased in patients with septic shock (SS) with a favorab......

JIF:7.405

Efficacy and safety of CD19-specific CAR T cell-based therapy in B-cell acute lymphoblastic leukemia patients

期刊: BLOOD, 2022; 139 (23)

Few studies have described chimeric antigen receptor (CAR) T-cell therapy for patients with B-cell acute lymphoblastic leukemia (B-ALL) with central n......

JIF:7.405

TP53 copy number and protein expression inform mutation status across risk categories in acute myeloid leukemia

期刊: BLOOD, 2022; 140 (1)

Mutant TP53 is an adverse risk factor in acute myeloid leukemia (AML), but large-scale integrated genomic-proteomic analyses of TP53 alterations in pa......

JIF:7.405

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