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Impact of HIV-1 CRF55_01B infection on the evolution of CD4 count and plasma HIV RNA load in men who have sex with men prior to antiretroviral therapy

期刊: RETROVIROLOGY, 2021; 18 (1)

Background CRF55_01B is a newly identified HIV-1 circulating recombinant form originated from MSM in China. However, its impact on the disease progres......

Seroprevalence of human T-lymphotropic virus infection among blood donors in China: a first nationwide survey

期刊: RETROVIROLOGY, 2021; 18 (1)

Background: So far, the prevalence of human T-lymphotropic virus (HTLV) type 1 and 2 in some highly populated countries such as China is still unknown......

Elevated levels of inflammatory plasma biomarkers are associated with risk of HIV infection

期刊: RETROVIROLOGY, 2021; 18 (1)

Background To determine if individuals, from HIV-1 serodiscordant couple cohorts from Rwanda and Zambia, who become HIV-positive have a distinct infla......

Identification of the distribution of human endogenous retroviruses K (HML-2) by PCR-based target enrichment sequencing

期刊: RETROVIROLOGY, 2020; 17 (1)

Background Human endogenous retroviruses (HERVs), suspected to be transposition-defective, may reshape the transcriptional network of the human genome......

MxB impedes the NUP358-mediated HIV-1 pre-integration complex nuclear import and viral replication cooperatively with CPSF6

期刊: RETROVIROLOGY, 2020; 17 (1)

Background The human myxovirus resistance 2 (Mx2/MxB) protein was originally found to regulate cytoplasmic-nuclear transport but was recently reported......

Effect of induced dNTP pool imbalance on HIV-1 reverse transcription in macrophages

期刊: RETROVIROLOGY, 2019; 16 (1)

Background Terminally differentiated/nondividing macrophages, a key target cell type of HIV-1, harbor extremely low dNTP concentrations established by......

JIF:3.74

Mutations of Glu560 within HIV-1 Envelope Glycoprotein N-terminal heptad repeat region contribute to resistance to peptide inhibitors of virus entry

期刊: RETROVIROLOGY, 2019; 16 (1)

Background: Peptides corresponding to N- and C-terminal heptad repeat regions (HR1 and HR2, respectively) of gp41 can inhibit HIV-1 infection in a dom......

JIF:3.74

Clonal anergy of CD117(+)chB6(+) B cell progenitors induced by avian leukosis virus subgroup J is associated with immunological tolerance

期刊: RETROVIROLOGY, 2019; 16 ()

BackgroundThe pathogenesis of immunological tolerance caused by avian leukosis virus subgroup J (ALV-J), an oncogenic retrovirus, is largely unknown.R......

JIF:3.74

Sequential trafficking of Env and Gag to HIV-1 T cell virological synapses revealed by live imaging

期刊: RETROVIROLOGY, 2019; 16 ()

BackgroundHIV infection is enhanced by cell adhesions that form between infected and uninfected T cells called virological synapses (VS). VS are initi......

JIF:3.74

Hypericin-photodynamic therapy inhibits the growth of adult T-cell leukemia cells through induction of apoptosis and suppression of viral transcription

期刊: RETROVIROLOGY, 2019; 16 ()

BackgroundAdult T-cell leukemia (ATL) is an aggressive neoplasm caused by human T-cell leukemia virus type 1 (HTLV-1). ATL carries a poor prognosis du......

JIF:3.74

CCR5 editing by Staphylococcus aureus Cas9 in human primary CD4(+) T cells and hematopoietic stem/progenitor cells promotes HIV-1 resistance and CD4(+) T cell enrichment in humanized mice

期刊: RETROVIROLOGY, 2019; 16 ()

BackgroundThe chemokine receptor CCR5, which belongs to the superfamily of G protein-coupled receptors, is the major co-receptor for HIV-1 entry. Indi......

JIF:3.74

CCR5 editing by Staphylococcus aureus Cas9 in human primary CD4(+) T cells and hematopoietic stem/progenitor cells promotes HIV-1 resistance and CD4(+) T cell enrichment in humanized mice (vol 16, 15, 2019)

期刊: RETROVIROLOGY, 2019; 16 ()

Following publication of their article [1], the authors realized that they inadvertently omitted the contribution of Dr. Li Wu (Ohio State University)......

JIF:3.74

Host SAMHD1 protein restricts endogenous reverse transcription of HIV-1 in nondividing macrophages

期刊: RETROVIROLOGY, 2018; 15 ()

BackgroundSAM domain and HD domain containing protein 1 (SAMHD1) is a host anti-HIV-1 restriction factor known to suppress viral reverse transcription......

JIF:3.74

Non-coding RNAs and retroviruses

期刊: RETROVIROLOGY, 2018; 15 ()

Retroviruses can cause severe diseases such as cancer and acquired immunodeficiency syndrome. A unique feature in the life cycle of retroviruses is th......

JIF:3.74

Six-helix bundle completion in the distal C-terminal heptad repeat region of gp41 is required for efficient human immunodeficiency virus type 1 infection

期刊: RETROVIROLOGY, 2018; 15 ()

Background: The native pre-fusion structure of gp120/gp41 complex of human immunodeficiency virus type 1 was recently revealed. In the model, the heli......

JIF:3.74

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