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Current advances in house dust mite allergen immunotherapy (AIT): Routes of administration, biomarkers and molecular allergen profiling

期刊: MOLECULAR IMMUNOLOGY, 2023; 155 ()

Allergy to house dust mites (HDM) is a perennial respiratory disease that affect more than half a billion people worldwide. Dermatophagoides pteronyss......

Development of a human antibody fragment cross-neutralizing scorpion toxins

期刊: MOLECULAR IMMUNOLOGY, 2023; 155 ()

Previously, it was demonstrated that from the single chain fragment variable (scFv) 3F it is possible to generate variants capable of neutralizing the......

Immunomodulation of cytokine signalling at feto-maternal interface by microRNA-223 and-150-5p in infection-associated spontaneous preterm birth

期刊: MOLECULAR IMMUNOLOGY, 2023; 160 ()

Spontaneous preterm birth (sPTB) is a global health concern and it is the most prevalent cause of infant mortality and morbidity with occurrence rate ......

Novel type-I interferons from the dromedary camel: Molecular identification, prokaryotic expression and functional characterization of camelid interferon-delta

期刊: MOLECULAR IMMUNOLOGY, 2023; 153 ()

The last two decades have seen the emergence of three highly pathogenic coronaviruses with zoonotic origins, which prompted immediate attention to the......

CD1a-mediated immunity from a molecular perspective

期刊: MOLECULAR IMMUNOLOGY, 2023; 158 ()

Human CD1a is a non-polymorphic glycoprotein that presents lipid antigens to T cells. The most obvious role of CD1a is associated with its expression ......

Tracing the origin of fish immunoglobulins

期刊: MOLECULAR IMMUNOLOGY, 2023; 153 ()

We have studied the origin of immunoglobulin genes in fish. There are two evolutionary lines of bony fish, Actinopterygii and Sarcopterygii. The forme......

Recombinant endonuclease III protein from Leishmania infantum associated with Th1-type adjuvants is immunogenic and induces protection against visceral leishmaniasis

期刊: MOLECULAR IMMUNOLOGY, 2023; 155 ()

Vaccination against visceral leishmaniasis (VL) should be considered as a safe and effective measure to disease control; however, few vaccines are ava......

Phenotypic, functional and plasticity features of human PBMCs induced by venom secreted PLA2s

期刊: MOLECULAR IMMUNOLOGY, 2023; 155 ()

Bothrops venom contains a high amount of secreted phospholipase A2 (sPLA2s) enzymes responsible for the in-flammatory reaction and activation of leuko......

Polyspecificity- An emerging trend in the development of clinical antibodies

期刊: MOLECULAR IMMUNOLOGY, 2023; 155 ()

The essence of the growth and development of therapeutic conventional monoclonal antibodies (MAbs) for the treatment of various disorders is the aptit......

Differential gene expression of cytokines, receptors, and miRNAs in individuals living with HIV-1 and vaccinated against yellow fever

期刊: MOLECULAR IMMUNOLOGY, 2023; 164 ()

Between 2016 and 2018, Brazil faced a yellow fever (YF) outbreak, which led to an expansion of vaccination coverage. The coexistence of the YF outbrea......

Cross-reactivity analysis of milk proteins from different goat breeds with cow?s milk allergens using a proteomic approach

期刊: MOLECULAR IMMUNOLOGY, 2023; 155 ()

Introduction: Goat's milk thought to be a good substitute for cow's milk protein allergic (CMPA) individuals. However, there is growing evidence that ......

Tumor antigen-unbiased variable epitope library contains mimotopes with antitumor effect in a mouse model of breast cancer

期刊: MOLECULAR IMMUNOLOGY, 2023; 157 ()

Breast cancer is one of the leading causes of death that affects the female population worldwide. Despite advances in treatments and a greater underst......

Adjuvantation of whole-killed Leishmania vaccine with anti-CD200 and anti-CD300a antibodies potentiates its efficacy and provides protection against wild-type parasites

期刊: MOLECULAR IMMUNOLOGY, 2023; 163 ()

One of the major reasons behind the limited success of vaccine candidates against all forms of leishmaniasis is the inability of parasitic antigens to......

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