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Evolutionarily conservative and non-conservative regulatory networks during primate interneuron development revealed by single-cell RNA and ATAC sequencing

期刊: CELL RESEARCH, 2022; 32 (5)

The differences in size and function between primate and rodent brains, and the association of disturbed excitatory/inhibitory balance with many neuro......

JIF:10.533

Nuclear RIPK1 promotes chromatin remodeling to mediate inflammatory response

期刊: CELL RESEARCH, 2022; 32 (7)

RIPK1 is a master regulator of multiple cell death pathways, including apoptosis and necroptosis, and inflammation. Importantly, activation of RIPK1 h......

JIF:10.533

Integrated proteogenomic characterization across major histological types of pituitary neuroendocrine tumors

期刊: CELL RESEARCH, 2022; 32 (12)

Pituitary neuroendocrine tumor (PitNET) is one of the most common intracranial tumors. Due to its extensive tumor heterogeneity and the lack of high-q......

JIF:10.533

A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs

期刊: CELL RESEARCH, 2022; 32 (3)

The emergence of SARS-CoV-2 variants and potentially other highly pathogenic sarbecoviruses in the future highlights the need for pan-sarbecovirus vac......

JIF:10.533

Near-atomic structure of the inner ring of the Saccharomyces cerevisiae nuclear pore complex

期刊: CELL RESEARCH, 2022; 32 (5)

Nuclear pore complexes (NPCs) mediate bidirectional nucleocytoplasmic transport of substances in eukaryotic cells. However, the accurate molecular arr......

JIF:10.533

Run! White blood cells cued by a motor brain under stress

期刊: CELL RESEARCH, 2022; 32 (11)

A recent study by Poller et al. published in Nature explores brain control of leukocyte distribution following acute stress and implicates motor circu......

JIF:10.533

Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia

期刊: CELL RESEARCH, 2022; 32 (12)

Aberrant self-renewal of leukemia initiation cells (LICs) drives aggressive acute myeloid leukemia (AML). Here, we report that UHRF1, an epigenetic re......

JIF:10.533

A variant-proof SARS-CoV-2 vaccine targeting HR1 domain in S2 subunit of spike protein

期刊: CELL RESEARCH, 2022; 32 (12)

The emerging SARS-CoV-2 variants, commonly with many mutations in S1 subunit of spike (S) protein are weakening the efficacy of the current vaccines a......

JIF:10.533

Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and their preclinical neuroprotective activity

期刊: CELL RESEARCH, 2022; 32 (6)

The decline of nicotinamide adenine dinucleotide (NAD) occurs in a variety of human pathologies including neurodegeneration. NAD-boosting agents can p......

JIF:10.533

SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors

期刊: CELL RESEARCH, 2022; 32 (7)

Mutant isocitrate dehydrogenase 1 (mIDH1) drives tumorigenesis via producing oncometabolite R-2-hydroxyglutarate (R-2-HG) across various tumor types. ......

JIF:10.533

Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate

期刊: CELL RESEARCH, 2022; 32 (3)

Hedgehog (Hh) is a morphogen that binds to its receptor Patched 1 and activates Smoothened (SMO), thereby governing embryonic development and postnata......

JIF:10.533

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