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A CRISPR toolbox for generating intersectional genetic mouse models for functional, molecular, and anatomical circuit mapping

期刊: BMC BIOLOGY, 2022; 20 (1)

Background The functional understanding of genetic interaction networks and cellular mechanisms governing health and disease requires the dissection, ......

JIF:5.914

Highly reliable creation of floxed alleles by electroporating single-cell embryos

期刊: BMC BIOLOGY, 2022; 20 (1)

Background Floxed (flanked by loxP) alleles are a crucial portion of conditional knockout mouse models. However, an efficient and reliable strategy to......

JIF:5.914

Analysis of echolocation behavior of bats in echo space using acoustic simulation

期刊: BMC BIOLOGY, 2022; 20 (1)

Background Echolocating bats use echo information to perceive space, control their behavior, and adjust flight navigation strategies in various enviro......

JIF:5.914

Phylogenomic analysis of Syngnathidae reveals novel relationships, origins of endemic diversity and variable diversification rates

期刊: BMC BIOLOGY, 2022; 20 (1)

Background Seahorses, seadragons, pygmy pipehorses, and pipefishes (Syngnathidae, Syngnathiformes) are among the most recognizable groups of fishes be......

JIF:5.914

Diet of Mesozoic toothed birds (Longipterygidae) inferred from quantitative analysis of extant avian diet proxies

期刊: BMC BIOLOGY, 2022; 20 (1)

Background Birds are key indicator species in extant ecosystems, and thus we would expect extinct birds to provide insights into the nature of ancient......

JIF:5.914

Investigating the characteristics of genes and variants associated with self-reported hearing difficulty in older adults in the UK Biobank

期刊: BMC BIOLOGY, 2022; 20 (1)

Background Age-related hearing loss is a common, heterogeneous disease with a strong genetic component. More than 100 loci have been reported to be in......

JIF:5.914

Comparative genomic analysis of Babesia duncani responsible for human babesiosis

期刊: BMC BIOLOGY, 2022; 20 (1)

Background Human babesiosis, caused by parasites of the genus Babesia, is an emerging and re-emerging tick-borne disease that is mainly transmitted by......

JIF:5.914

Analysis of archaic human haplotypes suggests that 5hmC acts as an epigenetic guide for NCO recombination

期刊: BMC BIOLOGY, 2022; 20 (1)

Background Non-crossover (NCO) refers to a mechanism of homologous recombination in which short tracks of DNA are copied between homologue chromatids.......

JIF:5.914

Lineage tracing shows that cell size asymmetries predict the dorsoventral axis in the sea star embryo

期刊: BMC BIOLOGY, 2022; 20 (1)

Background Cell size asymmetries are often linked to cell fate decisions, due to cell volumes and cell fate determinants being unequally partitioned d......

JIF:5.914

ERF49 mediates brassinosteroid regulation of heat stress tolerance in Arabidopsis thaliana

期刊: BMC BIOLOGY, 2022; 20 (1)

Background Heat stress is a major abiotic stress affecting the growth and development of plants, including crop species. Plants have evolved various a......

JIF:5.914

Systematic characterization of seed overlap microRNA cotargeting associated with lupus pathogenesis

期刊: BMC BIOLOGY, 2022; 20 (1)

Background Combinatorial gene regulation by multiple microRNAs (miRNAs) is widespread and closely spaced target sites often act cooperatively to achie......

JIF:5.914

Stem cell-derived porcine macrophages as a new platform for studying host-pathogen interactions

期刊: BMC BIOLOGY, 2022; 20 (1)

Background Infectious diseases of farmed and wild animals pose a recurrent threat to food security and human health. The macrophage, a key component o......

JIF:5.914

A comparative methylome analysis reveals conservation and divergence of DNA methylation patterns and functions in vertebrates

期刊: BMC BIOLOGY, 2022; 20 (1)

Background Cytosine DNA methylation is a heritable epigenetic mark present in most eukaryotic groups. While the patterns and functions of DNA methylat......

JIF:5.914

A method for ultrafast tissue clearing that preserves fluorescence for multimodal and longitudinal brain imaging

期刊: BMC BIOLOGY, 2022; 20 (1)

Background Tissue-clearing techniques have recently been developed to make tissues transparent for three-dimensional (3D) imaging at different scales,......

JIF:5.914

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