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Single-cell multiomics analysis reveals regulatory programs in clear cell renal cell carcinoma

期刊: CELL DISCOVERY, 2022; 8 (1)

The clear cell renal cell carcinoma (ccRCC) microenvironment consists of many different cell types and structural components that play critical roles ......

JIF:5.787

Single-cell RNA sequencing identifies an Il1rn(+)/Trem1(+) macrophage subpopulation as a cellular target for mitigating the progression of thoracic aortic aneurysm and dissection

期刊: CELL DISCOVERY, 2022; 8 (1)

Thoracic aortic aneurysm and dissection (TAAD) is a life-threatening condition characterized by medial layer degeneration of the thoracic aorta. A tho......

JIF:5.787

Structural insights into the ligand binding and G(i) coupling of serotonin receptor 5-HT5A

期刊: CELL DISCOVERY, 2022; 8 (1)

5-hydroxytryptamine receptor 5A (5-HT5A) belongs to the 5-HT receptor family and signals through the G(i/o) protein. It is involved in nervous system ......

JIF:5.787

Metabolic control of histone acetylation for precise and timely regulation of minor ZGA in early mammalian embryos

期刊: CELL DISCOVERY, 2022; 8 (1)

Metabolism feeds into the regulation of epigenetics via metabolic enzymes and metabolites. However, metabolic features, and their impact on epigenetic......

JIF:5.787

Identification of a rare Gli1(+) progenitor cell population contributing to liver regeneration during chronic injury

期刊: CELL DISCOVERY, 2022; 8 (1)

In adults, hepatocytes are mainly replenished from the existing progenitor pools of hepatocytes and cholangiocytes during chronic liver injury. Howeve......

JIF:5.787

Wnt signaling polarizes cortical actin polymerization to increase daughter cell asymmetry

期刊: CELL DISCOVERY, 2022; 8 (1)

Asymmetric positioning of the mitotic spindle contributes to the generation of two daughter cells with distinct sizes and fates. Here, we investigated......

JIF:5.787

Single-cell transcriptomics reveals lineage trajectory of human scalp hair follicle and informs mechanisms of hair graying

期刊: CELL DISCOVERY, 2022; 8 (1)

Hair conditions, such as hair loss and graying, are prevalent human conditions. But they are often poorly controlled due to our insufficient understan......

JIF:5.787

Structural insights into human CCAN complex assembled onto DNA

期刊: CELL DISCOVERY, 2022; 8 (1)

In mitosis, accurate chromosome segregation depends on kinetochores that connect centromeric chromatin to spindle microtubules. The centromeres of bud......

JIF:5.787

SFRP4(+) stromal cell subpopulation with IGF1 signaling in human endometrial regeneration

期刊: CELL DISCOVERY, 2022; 8 (1)

Our understanding of full-thickness endometrial regeneration after injury is limited by an incomplete molecular characterization of the cell populatio......

JIF:5.787

ALKBH3-dependent m(1)A demethylation of Aurora A mRNA inhibits ciliogenesis

期刊: CELL DISCOVERY, 2022; 8 (1)

Primary cilia are antenna-like subcellular structures to act as signaling platforms to regulate many cellular processes and embryonic development. m(1......

JIF:5.787

Chilling-induced phosphorylation of IPA1 by OsSAPK6 activates chilling tolerance responses in rice

期刊: CELL DISCOVERY, 2022; 8 (1)

Chilling is a major abiotic stress harming rice development and productivity. The C-REPEAT BINDING FACTOR (CBF)-dependent transcriptional regulatory p......

JIF:5.787

Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state

期刊: CELL DISCOVERY, 2022; 8 (1)

The conserved ATPase p97 (Cdc48 in yeast) and adaptors mediate diverse cellular processes through unfolding polyubiquitinated proteins and extracting ......

JIF:5.787

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