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Disordered gut microbiota promotes atrial fibrillation by aggravated conduction disturbance and unbalanced linoleic acid/SIRT1 signaling

期刊: BIOCHEMICAL PHARMACOLOGY, 2023; 213 ()

Emerging evidence suggests an association of dysbiotic gut microbiota (GM) with atrial fibrillation (AF). The current study aimed to determine whether......

Next generation organoid engineering to replace animals in cancer drug testing

期刊: BIOCHEMICAL PHARMACOLOGY, 2023; 213 ()

Cancer therapies have several clinical challenges associated with them, namely treatment toxicity, treatment resistance and relapse. Due to factors ra......

Neratinib is a TFEB and TFE3 activator that potentiates autophagy and unbalances energy metabolism in ERBB2+breast cancer cells

期刊: BIOCHEMICAL PHARMACOLOGY, 2023; 213 ()

Neratinib (NE) is an irreversible pan-ERBB tyrosine kinase inhibitor used to treat breast cancers (BCa) with amplification of the ERBB2/HER2/Neu gene ......

Understanding resistance acquisition by Pseudomonas aeruginosa and possible pharmacological approaches in palliating its pathogenesis

期刊: BIOCHEMICAL PHARMACOLOGY, 2023; 215 ()

Pseudomonas aeruginosa can utilize various virulence factors necessary for host infection and persistence. These virulence factors include pyocyanin, ......

Activation of NLRP2 in Triple-Negative Breast Cancer sensitizes chemotherapeutic therapy through facilitating hnRNPK function

期刊: BIOCHEMICAL PHARMACOLOGY, 2023; 215 ()

Nucleotide-binding oligomerization domain (NOD)-like receptor type 2 protein (NLRP2) was reported to inhibit NF -KB in response to inflammatory stimul......

Otilonium Bromide acts as a selective USP28 inhibitor and exhibits cytotoxic activity against multiple human cancer cell lines

期刊: BIOCHEMICAL PHARMACOLOGY, 2023; 215 ()

USP28 contributes to tumorigenesis through modulating the lifespan of oncogenic factors such as c-Myc and & UDelta;Np63, and it has been identifie......

ASCT2-mediated glutamine uptake promotes Th1 differentiation via ROS-EGR1-PAC1 pathway in oral lichen planus

期刊: BIOCHEMICAL PHARMACOLOGY, 2023; 216 ()

Oral lichen planus (OLP) is a T cell-mediated autoimmune disease of oral mucosa concerning with the redox imbalance. Although glutamine uptake mediate......

Torachrysone-8-O-β-D-glucoside mediates anti-inflammatory effects by blocking aldose reductase-catalyzed metabolism of lipid peroxidation products

期刊: BIOCHEMICAL PHARMACOLOGY, 2023; 218 ()

Aldose reductase (AR) is an important enzyme involved in the reduction of various aldehyde and carbonyl compounds, including the highly reactive and t......

Role of Gi proteins in the regulation of blood pressure and vascular remodeling

期刊: BIOCHEMICAL PHARMACOLOGY, 2023; 208 ()

Heterotrimeric guanine nucleotide regulatory proteins (G-proteins) through the activation of several signaling mechanisms including adenylyl cyclase/c......

Soluble TIM-3 as a biomarker of progression and therapeutic response in cancers and other of human diseases

期刊: BIOCHEMICAL PHARMACOLOGY, 2023; 209 ()

Immune checkpoints inhibition is a privileged approach to combat cancers and other human diseases. The TIM-3 (T cell immunoglobulin and mucin-domain c......

The role of exosomes in the stemness maintenance and progression of acute myeloid leukemia

期刊: BIOCHEMICAL PHARMACOLOGY, 2023; 212 ()

Acute myeloid leukemia (AML) is an aggressive malignancy of myeloid hematopoietic cells, which is characterized by the aberrant clonal proliferation o......

CircRNA-mediated ceRNA mechanism in Osteoarthritis: Special emphasis on circRNAs in exosomes and the crosstalk of circRNAs and RNA methylation

期刊: BIOCHEMICAL PHARMACOLOGY, 2023; 212 ()

Osteoarthritis (OA) is an age-related joint disease with chronic inflammation, progressive articular cartilage destruction and subchondral bone sclero......

Macrophage scavenger receptor A1 antagonizes abdominal aortic aneurysm via upregulating IRG1

期刊: BIOCHEMICAL PHARMACOLOGY, 2023; 213 ()

Aims: Abdominal aortic aneurysm (AAA) is a common, usually asymptomatic disease with high mortality and limited therapeutic options. Extensive extrace......

Potent salinomycin C20-O-alkyl oxime derivative SAL-98 efficiently inhibits tumor growth and metastasis by affecting Wnt/13-catenin signal pathway

期刊: BIOCHEMICAL PHARMACOLOGY, 2023; 214 ()

The dysregulation of Wnt/13-catenin signaling pathway is closely related to tumorigenesis, metastasis and cancer stem cell maintenance. Salinomycin is......

Metformin-mediated epigenetic modifications in diabetes and associated conditions: Biological and clinical relevance

期刊: BIOCHEMICAL PHARMACOLOGY, 2023; 215 ()

An intricate interplay between genetic and environmental factors contributes to the development of type 2 diabetes (T2D) and its complications. Theref......

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